Research Projects & Grants

  • A multi-center, randomized, parallel group, comparative, active controlled, safety-assessor blinded, anesthesiologist TOF-Watch® SX blinded trial comparing T4/T1 ratio at time of tracheal extubation using 4.0 mg.kg-1 sugammadex administered at 1-2 PTCs or better aftet the last dose of rocuronium bromide to 50 ug.kg-1 neostigmine administered as per standard of care in adult subjects undergoing elective open abdominal procedures requirig neuromuscular blockade reversal. Protocol No. 19.4.334, Role: PI, (02/2009 - 02/2010) Status: Completed

College/University

  • Development of a predictive model for post-discharge nausea and vomiting (PDNV), Role: PI, University of California, San Francisco, (09/2008 - 09/2009) Status: Completed

For Profit Organization

  • A phase III, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of dexmedetomidine for sedation during monitored anesthesia care. Protocol number 2005-005. Version Date: 26 July 2006, Role: PI, Hospira, Inc., (10/2006 - 10/2007) Status: Completed
  • CP-09-005, Rev.1.0: A sedline data collection study during emergence, Role: PI, Hospira, Inc., (11/2006 - 11/2007) Status: Completed
  • Protocol 021048- An open-label, randomized, phase IIIB, multicenter trial to evaluate the pharmacodynamic parameters of intubation bolus, and bolus and infusion maintenance doses of Zemuron® in pediatric and adolescent subjects. Amendments 1, 2, 3,4, 5, 6, 7, and 8 inclusive. Version date: January 2006., Role: PI, Organon USA Inc., (06/2007 - 06/2008) Status: Completed
  • A phase III, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine used for sedation during elective awake fiberoptic intubation. Protocol Number 2005-006, Version date (April 28, 2006, Amendment 1), Role: PI, Hospira, Inc., (07/2006 - 07/2007) Status: Completed
  • A prospective study to evaluate the depth of sedation in patients undergoing procedural sedation, Role: Investigator, Hospira, Inc., (10/2006 - 10/2007) Status: Completed
  • A multicenter, open label, phase IIIa trial to evaluate the efficacy and safety of Org 25969 when used at the end of surgical procedure to reverse the neuromuscular block induced by rocuronium following routine anesthesia. Protocol #19.4.311, Amendment 1., Role: PI, Organon USA Inc., (09/2006 - 09/2007) Status: Completed
  • A multicenter, randomized, parallel group, comparative, safety-assessor blinded, phase IIIa trial in adult surgical subjects under general anesthesia at increased risk for pulmonary complications. Protocol 19.4.308, Role: PI, Organon USA Inc., (08/2006 - 08/2007) Status: Completed
  • A prospective study to evaluate the effectiveness of the masimo pulse co-oximeter in detecting methemoglobinemia in high risk patients, Role: PI, Masimo Inc., (10/2006 - 10/2007) Status: Completed
  • A multicenter, randomized, double-blind, placebo-controlled, dose-ranging, parallel group phase II study to evaluate the safety, efficacy, and pharmacokinetics of the oral neurokinin-1 receptor antagonist, GW679769, when administered with intravenous ondansetron hydrochloride for the prevention of post-operative nausea and vomiting (PONV) and post-discharge nausea and vomiting (PDNV) in female subjects with known risk factors for PONV who are undergoing surgical procedures associated with an inc, Role: PI, GlaxoSmithKline, (07/2005 - 07/2006) Status: Completed
  • A prospective study to evaluate the performance of combined monitoring of pulse oximetry, continuous acoustic respiratory rate, and processed EEG in patients undergoing procedural sedation, Role: Investigator, Masimo Inc., (10/2015 - 10/2016) Status: Completed
  • Esmolol or nitroglycerin infusion for blood pressure control prior to CPB in cardiac surgery: a randomized, controlled trial, Role: Investigator, Baxter Healthcare Corporation, (07/2013 - 07/2014) Status: Completed

Internal

  • Intra Operative Transesophageal Cardiac Pacing, Role: PI, LLU Dept. of Anesthesiology, (10/1994 - 10/1995) Status: Completed
  • A comparative study of standard electroencephalogram (EEG) versus PSA EEG monitoring in evaluating EEG burst suppression in elective craniotomies, Role: PI, LLU Dept. of Anesthesiology, (02/2006 - 02/2007) Status: Completed
  • Incidence of postoperative cognitive dysfunction in elderly patients following desflurane or sevoflurane general anesthesia, Role: Investigator, LLU Dept. of Anesthesiology, (08/2013 - 08/2014) Status: Completed
  • Comparison of two methods for determination of cardiac output and stroke volume variation during anesthesia, Role: Investigator, LLU Dept. of Anesthesiology, (05/2013 - 05/2014) Status: Completed