Presentation

Poster

  • De León, D.D. and Barkley, M.S. l984.  Male Genotype influences the regularity of the estrous cycle in selected strains of mice. Biol Rep 30: Suppl. 1:167 (06/1984)
  • De León, D.D. and Barkley, M.S. l986. Male genotype influences estrous cyclicity in the mouse. Proc Fed Amer Soc Exp Biol 45(3):303. (06/1986)
  • De León, D.D. and Barkley, M.S. l987. LH receptors and progesterone secretion during the estrous cycle among inbred strains of mice. Biol Rep 36: Suppl. l:232. (06/1987)
  • De León, D.D., Bakker B., and Wilson, D.M., 1988.  Insulin-like growth factors and binding proteins in human breast cancer cells. Endocrine Society  70thAnnual Meeting, New Orleans, Abs. # 865:p.237 (06/1988)
  • Mehta, K. R. and De León, D.D. 1998. Effect of IGFBP-4 in Breast Cancer Cell Proliferation.  80th Annual Meeting of the Endocrine Society.  New Orleans, LA (06/1988 - 06/1998)
  • Bakker,B., Wilson, D.M., Lamson, G., De León, D.D., Powers, M., Rosenfeld, R.G. and Hintz, R.L. 1989. Insulin-Like Growth factor I and II in human breast cancer cell line: A Re-evaluation. Clinical Research 37(1):192 A. (06/1989)
  • De León, D.D., Wilson D.M., Powers, M., Lamson G. and Rosenfeld, R.G. 1990. Hormonal Regulation of Insulin-like growth factors in human breast cancer cells. Cellular and Molecular biology of breast cancer/ UCLA Symposia. Tamarron, Colorado. J. Cell Biochem. Suppl. 14B. (06/1990)
  • De León, D.D. and Wilson D.M. 1990. Role of Insulin-like growth factors in human breast cancer cell proliferation: Effects of insulin-like growth factor receptor antibodies. Endocrine Society 72nd Annual Meeting, Atlanta, GA. (07/1990 - 06/1990)
  • Lopaczynsky,W., Thomas, C.L., De León, D.D., Phang, L., Blakemore, K.J., Kelley, R.I. and  Nissley, P. 1992. Insulin-like growth factor-I receptor expression and function in fibroblasts from 2 patients with deletion of the distal arm of chromosome 15. Endocrine Society 74th Annual Meeting, San Antonio, TX. (06/1992)
  • De León, D.D., Terry C. and Nissley P. 1993. Rapid and sensitive detection of insulin-like growth factor II by chemiluminescence: Dot-blot analysis. Endocrine Society 75th Annual Meeting, Las Vegas Nevada. (06/1993)
  • De León, D.D. ,Terry C. and Nissley P., 1994.   Expression of Insulin-like growth factor II (IGF-II) in MCF-7 Breast Cancer cells increases the secretion of Cathepsin-D. ASCB 34th Annual Meeting, San Francisco, CA. (12/1994)
  • Issa, N.N, Boynton, B.P., Ulloth, L., Nainani, S.B., and De León, D.D. 1996.  Modulation of Cathepsin D by IGF-II in Breast Cancer Cells. American Federation of Clinical Research, Carmel, CA. (02/1996)
  • Issa, N.N, Boynton, B.P., Ulloth, L., Nainani, S.B., and De León, D.D. 1996.  IGF-II modulation of cathepsin D secretion in breast cancer cells: Effect of IGF-II antisense expression.  10th International Congress of Endocrinology.  San Francisco CA (06/1996)
  • Mehta, K. and De León, D.D. 1996.  Antiestrogen Modulation of Breast Cancer Cell Growth Through IGFBP-4 Regulation.  10th International Congress of Endocrinology.  San Francisco CA. (06/1996)
  • Chen, Q., Bowman, R., Ota, M., Heustis, D. and De León, D.D. 1997. Immunohistochemical Analysis of Breast Cathepsin D In Ten Breast Cancer Patients.  ASCP/CAP (09/1997)
  • De León, D.D., Asmerom, Y., Kanacki, Z., and Garberoglio, C.,  1999. Cathepsin D in Breast Cancer.  California Breast Cancer Program. Second Symposium, Los Angeles, CA. (05/1999)
  • Faridi, J.S. and De León, D.D. 1999. Interactions of IGF-II in MCF-7 Breast Cancer Cells: Role of the IGF-II/M6P Receptor. 81st Annual Meeting of the Endocrine Society.  San Diego, CA. (06/1999)
  • Jian, T., and De León, D.D., 2000.  Expression of ProIGF-II and not IGF-II in the human breast cancer cell line MCF-7 induces loss of estrogen requirement for tumor growth in nude and SCID mice. 82nd Annual Meeting of the Endocrine Society.  Toronto, Canada (06/2000)
  • Nainani, S.R. and De León, D.D., 2000. "Resveratrol regulates IGF-II and cathepsin D routing in MCF-10 breast epithelial cells". 82nd Annual Meeting of the Endocrine Society.  Toronto, Canada. (06/2000)
  • De León, D. D. and Garberoglio, C., 2002.  Insulin like Growth Factor II (IGF-II) as a prognostic indicator for breast cancer. Breast Cancer  Research Symposium, Oakland, California. (03/2002)
  • Ying, N., Jo-Wen, L., De Leon, M.,  De Leon, D.D., 2002. Human epidermal-type fatty acid-binding protein as a breast tumor suppressor. 93rd Annual Meeting of American Association for Cancer Research, San Francisco, California (04/2002)
  • Faridi, J.S. and De León, D.D. 2000. Interactions of IGF-II in MCF-7 Breast Cancer Cells: Role of the IGF-II/M6P Receptor. 82nd Annual Meeting of the Endocrine Society.  Toronto, Canada (06/2002)
  • Vyas, S., and De León, D.D., 2002. Resveratrol as a chemopreventive and chemotherapeutic agent for breast cancer.  93rd Annual Meeting of American Association for Cancer Research, San Francisco, California (10/2002)
  • Vyas, S., Asmerom, Y., and  De León, D.D., 2003. Differential modulation of cathepsin D and IGF-II by resveratrol in human breast cancer cell lines. 94th Annual Meeting of American Association for Cancer Research, Toronto, Canada (04/2003)
  • Vyas, S., and De León, D.D., 2003. Differential modulation of IGF-II by resveratrol in human breast cancer cell lines. 85th Annual Meeting of the Endocrine Society.  Philadelphia (06/2003)
  • Vyas, S., and De León, D.D., 2004. Resveratrol regulates IGF-II in MCF-7 human breast cancer cells. 95 th Annual Meeting of American Association for Cancer Research, Orlando, Florida (03/2004)
  • De León, D.D. 1995. Differential Expression of IGFBP's in MCF-7 breast cancer cell transfected with IGF-II or proIGF-II: Effect on cell growth. Endocrine Society 77 Annual Meeting, Washington D.C. (06/2005)
  • Vyas, S., and  De León, D.D., 2005. Resveratrol-Induced apoptosis is associated with IGF-II Down-regulation in MCF-7 Breast Cancer Cells. Endocrine Society 87th Annual Meeting, San Diego (06/2005)
  • De Leon, D. D. 2006 "IGF-II and cathepsin D in Breast Cancer is Associated with Health Disparities in African American Patients." Endocrine Society 88th Annual Meeting. Boston Convention Center, MA (6/2006 ) (06/2006)
  • Daisy D De Leon. "IGF-II and cathepsin D in Breast Cancer is Associated with Health Disparities in African American Patients." Endocrine Society 88th Annual Meeting. Boston Convention Center, MA (06/2006)
  • Vyas, Sharda, and D D. De León. " Differential Expression of IGF-II and Pro IGF-II Mediates Resveratrol-induced Apoptosis, Mitochondrial Polarization in MCF-7 cells. ." Endocrine Society 88th Annual Meeting. Boston Convention Center, MA (06/2006)
  • Ellerbee, A.P., Casiano, C.C., Brito, C. and De Leon, D.D. "Genistein and Curcumin Regulate proIGF-II to Promote Apoptosis of ER-/PR- Breast Cancer Cells from African American Patients ." 89th Endocrine Society Annual Meeting. Toronto, Canada (04/2007)
  • Vyas, S., Moretta, D., Almaguel, F., De Leon, F. and De Leon, D.D. 2007 "Differential expression of insulin-like growth factor II (IGF-II) and proIGF-II mediates resveratrol-induced apoptosis, mitochondrial polarization and proliferation in mcf-7 breast cancer cells." AACR Annual Meeting. Los Angeles, CA (04/2007)
  • Vyas, S., Moretta, D., Almaguel, F., De Leon, M. and De Leon, D.D. "DIFFERENTIAL EXPRESSION OF INSULIN-LIKE GROWTH FACTOR II (IGF-II) AND PROIGF-II MEDIATES RESVERATROL-INDUCED APOPTOSIS, MITOCHONDRIAL POLARIZATION AND PROLIFERATION IN MCF-7 BREAST CANCER CELLS." AACR Annual Meeting. Los Angeles, CA (04/2007)
  • Tesfai, J. and De León, D.D. 2007. Knockdown of IGF-II gene by SiRNA induces apoptosis and growth inhibition in MCF-7 breast cancer cell line. 89th Endocrine Society Annual Meeting. June 2007. Toronto, Canada. (06/2007)
  • Ellerbee, A.P., Casiano, C.C., Brito, C. and De Leon, D.D. 2007 "Genistein and Curcumin Regulate proIGF-II to Promote Apoptosis of ER-/PR- Breast Cancer Cells from African American Patients ." 89th Endocrine Society Annual Meeting. June 2007. Toronto, Canada. (06/2007)
  • Vyas, S., Moretta, D., Almaguel, F., De Leon, M. and De Leon, D.D. "INSULIN-LIKE GROWTH FACTOR II (IGF-II) AND PROIGF-II DIFFERENTIALLY REGULATE APOPTOSIS, Bcl-2 and Bcl-XL IN MCF-7 BREAST CANCER CELLS." 89th Endocrine Society Annual Meeting. Toronto, Canada (06/2007)
  • Ellerbee, A.P. Hamilton, N. and De León, D.D. 2007. IGF-II regulates phosphorylation of estrogen receptors In breast cancer cells from African American patients. AACR Health Disparities Meeting. December 2007. Atlanta Georgia (12/2007)
  • Vyas, S., Almaguel, F., De León, M. and De León, D.D. 2007. A Link to Breast Cancer Survival Disparity among African American Women: IGF-II Regulates Mitochondria to Prevent Apoptosis and Promote Chemoresistance. AACR Health Disparities Meeting. December 2007. Atlanta Georgia. (12/2007)
  • Ellerbee, A.P., Hamilton, N. and De León, D.D. 2008. IGF-II Phosphorylates and Activates ER-a and ER-b In African-American Breast Cancer Cell Lines . NIH Health Disparities Summit. Washington DC (04/2008)
  • Ellerbee, A.P.,  Hamilton, N. and De León, D.D. 2008. IGF-II regulates phosphorylation of estrogen receptors In breast cancer cells from African American patients. AACR Annual Meeting. April 2008. San Diego, CA (04/2008)
  • Kalla-Singh, S, Tan, Q.W. and De León, D.D. 2008. Insulin-Like Growth Factor II (IGF-II): A Role In Breast Cancer Survival Disparity Between African-American And Caucasian Females. NIH Health Disparities Summit. Washington DC (04/2008)
  • Vyas, S., Almaguel, F., De León, M. and De León, D.D. 2008. A Link to Breast Cancer Survival Disparity among African American Women: IGF-II Regulates Mitochondria to Prevent Apoptosis and Promote Chemoresistance. AACR Annual Meeting. April 2008. San Diego, CA. (04/2008)
  • Vyas, S., Moretta, D., Almaguel, F., De Leon, M. and De Leon, D.D. 2007 "Insulin-Like Growth Factor II (IGF-II) and Pro IGF-II Differentially Regulate Apoptosis, Bcl-2 Bcl-Xl In Mcf-7 Breast Cancer Cells." 89th Endocrine Society Annual Meeting. June 2007.  Toronto, Canada. (06/2008)
  • Ellerbee, A.P., Hamilton, N. and De León, D.D. 2009. The Role of IGF-II in Estrogen Independent Tumors in African-American Breast Cancer Cells. AACR Health Disparities Meeting. Carefree- Arizona (02/2009)
  • Kalla-Singh, S., Tan, Q.W. and  De León, D.D. 2009. Insulin-like Growth Factor II (IGF-II) and its receptors: A comparison Study between African-American and Caucasian Women in Normal and Malignant Breast tissues Samples. AACR Health Disparities Meeting. Carefree- Arizona (02/2009)
  • Ellerbee, A.P., Hamilton, N. and De León, D. D. 2009. IGF-II Regulates Phosphorylation of Estrogen Receptors In African American Breast Cancer Cells.  AACR Annual Meeting, Denver, CO. ** Awarded Susan G Komen Scholar-in-Training Award (04/2009)
  • Kalla-Singh, S., Tan, Q.W. and De León, D.D. 2009.  Insulin-like Growth Factor II (IGF-II) and its receptors: A comparison Study between African-American and Caucasian Women in Normal and Malignant Breast tissues Samples. AACR Annual Meeting, Denver, CO (04/2009)
  • Calderon, T., Kalla-Singh, S., De León, M.A., and De León, D.D. 2010. Differential expression of fatty-acid-binding proteins 3 and 5 among African American and Caucasian women with breast cancer. AACR Annual Meeting, Washington, DC. (04/2010)
  • Kalla-Singh, S., Tan, Q.W., Brito,C., De León, M.A. and  De León, D.D.  2010. Insulin-like growth factor II (IGF-II) differential activation of the IGF-1 and insulin receptors in african-american and caucasian breast cancer tissues. AACR Annual Meeting, Washington, DC (04/2010)
  • Vinodh Kumar Radhakrishnan, Marino De Leon and Daisy De Leon  (2011) Methylation status of CpG and DMR in differential expression of IGF-II gene in paired breast cancer tissues of African-American and Caucasian women. Gordon Conference, IGF’s in Health and Disease, Ventura, CA. February 27-March 4, 2011 (02/2011 - 03/2011)
  • Chané O’Bannon, Marino De León, and Daisy D. De León (2011) IGF-II regulates the expression of estrogen receptor beta 5: Role in the survival disparity between African-American and Caucasian women with breast cancer”. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1114. doi:10.1158/1538-7445.AM2011-1114 (04/2011)
  • N Hamilton, D De León (2011) IGF-II regulates the expression of estrogen receptor beta 5: Role in the survival disparity between African-American and Caucasian women with breast cancer In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; Apr 2-6; Orlando, FL. Cancer Research 71 (8 Supplement), 1114-1114 (04/2011)
  • Vinodh Kumar Radhakrishnan, Marino De Leon and Daisy De León  (2011) Methylation status of CpG and DMR in differential expression of IGF-II gene in paired breast cancer tissues of African-American and Caucasian women. AACR, Annual meeting, Orlando, Florida; April 2-6, 2011. (04/2011)
  • Helu XM and De León  DD (2012) IGF2 activation of HER2 receptor in HER2 positive  breast cancer cell lines. Annual AACR Meeting, March, Chicago, IL. Cancer Research 72 (8 Supplement), 3925-3925; DOI:10.1158/1538-7445.AM2012-3925. Marc 31-April 4, 2012 (03/2012 - 04/2012)
  • O’Bannon-Joseph, C. N., De Léon, D. D. (2012) Estrogen Receptor Beta Isoforms in breast cancer cells: IGF-II role in regulation of estrogen receptor beta isoforms. AACR , Chicago, IL. Cancer Res November 21 2014 72 (8 Supplement) 3913-3913; DOI:10.1158/1538-7445.AM2012-3913. March 31-April 4, 2012 (03/2012 - 04/2012)
  • Radhakrishnan, V., Anderson, K., De León, M., De León, D. (2012) Higher IGF-II expression in Vietnamese triple negative breast cancer tumors is dependent on Biallelic or Monoallelic IGF-II with ApaI SNP. AACR 2012 Annual Meeting, Chicago. Cancer Res November 21 2014 72 (8 Supplement) 3131-3131; DOI:10.1158/1538-7445.AM2012-3131 March 31-April 4, 2012 (03/2012 - 04/2012)
  • Teleka Calderon, Marino De León and Daisy D. De León  (2012) Differential IGF-II response of AA and CA normal breast cell lines to prolactin treatment.  Cancer Res November 21 2014 72 (8 Supplement) 22-22; DOI:10.1158/1538-7445.AM2012-22. March 31-April 4, 2012 (03/2012 - 04/2012)
  • Radhakrishnan, V., De León, M., De León, D. (2012) Differential expression of IGF-II in Vietnamese women triple negative breast cancer is dependent on biallelic or monoallelic IGF-II with ApaI SNP. Science of eliminating health disparities 2012 Summit Meeting, Maryland. October 31-Nov 2, 2012 (10/2012 - 11/2012)
  • Daisy D. De León, Vinodh Kumar Radhakrishnan, Qianwei Tan, Marino De León (2014) IGF-II is a link between diabetes and breast cancer among African American women. National Institute on Minority Health and Health Disparities Grantees' Conference. Washington, DC. (12/2014)
  • Vinodh Kumar Radhakrishnan, Qianwei Tan, Marino De León, Daisy D. De León (2014) Insulin like growth factor-II  Differentially Methylated Region is Determined by IGF-II gene imprinting in African American, Caucasian, Vietnamese, South Korean Breast Cancer Women. National Institute on Minority Health and Health Disparities Grantees' Conference. Washington, DC. December 1-3, 2014 (12/2014)
  • Chane' O'Bannon-Joseph, Daisy D. De León  (2015), Center for Health Disparities and Molecular Medicine. IGF-II causes translocation of estrogen receptor beta to the mitochondria in triple negative breast cancer cell lines. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3914. doi:10.1158/1538-7445.AM2015-3914. (04/2015)
  • Xousaen M. Helu, Daisy De León (2015). Inhibition of HER2 and IGF2 in trastuzumab-resistant HER2 positive JIMT1 cells decreases cell growth and reduces activation of MAPK and AKT. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3919. doi:10.1158/1538-7445.AM2015-3919 (04/2015)
  • Helu XM, Fernandez A, and De León, DD (2016). Inhibition of STAT3 in primary trastuzumab-resistant HER2-positive cells leads to decreased cell viability. Annual AACR Meeting, April 16 to 20, New Orleans, LA. Cancer Research 76 (14 Supplement), 4407-4407 (04/2016)
  • Vinodh Kumar Radhakrishnan and Daisy D. De León (2017), Center for Health Disparities and Molecular Medicine. IGF-II is a key player in determining the cancer metabolic shift with decreased levels of mtDNA content and efficient mitochondria in TNBC.  Gordon Research Conferences. Insulin-Like Growth Factors in Physiology & Disease; March 12-17; Ventura, CA. Poster nr 33. (Travel award granted). (03/2017)
  • Maria L. Pagan, Vinodh Kumar Radhakrishnan, Daisy D. De León (2017), Center for Health Disparities and Molecular Medicine. IGF2 regulated mitochondrial cell energy phenotype and biogenesis in TNBC cells. In: Proceedings of the 110th Annual Meeting of the American Association for Cancer Research; Apr 1-5; Washington, DC. Philadelphia, PA. Philadelphia (PA): AACR; Cancer Research 2017; 77 (13 Suppl): Abstract nr 4421. doi:10.1158/1538-7445.AM2017-4421. (04/2017)
  • Daisy D. De León, Marino De León and Vinodh K. Radhakrishnan.  (2017), IGF-II is a Key Player in the regulation of Cancer Metabolism by Regulating Mitochondrial DNA Content, Mitogenes and Energy Utilization in Breast Cancer (11/2017)

Research

  • Rosenfeld, R.G., Oh, Y., Neely E.K., De León, D.D., Cohen, P. Pham, H. 1990. New Perspectives in insulin-like growth factor receptors. Tokyo Growth Symposium.  (06/1990)
  • Vyas, S., and  De León, D.D., 2004. IGF-II regulation by resveratrol in human breast cancer cells. International Research Conference on Food, Nutrition and Cancer. Washington DC (07/2004)