Publications

Abstract

  • Katerji, M., A. Bertucci, V. Filippov, M. Vazquez, X. Chen and P. J. Duerksen-Hughes. Proton-induced DNA damage promotes integration of foreign plasmid DNA into Human Genome. Frontiers in Oncology:Radiation Oncology 12:928545. 2022. PMID: 36119491 (09/2022)

Scholarly Journals--Published

  • Katerji, M., A. Bertucci, V. Filippov, M. Vazquez, X. Chen and P. J. Duerksen-Hughes. Proton-induced DNA damage promotes integration of foreign plasmid DNA into Human Genome. Frontiers in Oncology:Radiation Oncology 12:928545. 2022. PMID: 36119491 (06/2022)
  • Whang, S. N., V. D. Shah, L. Pu, P. Sheth, G. N. Lucas, J. Lee, M. Lee, C. Lacy, P. J. Duerksen-Hughes, V. Filippov, D. H. J. Lee, J. Veltman, K. Maken, M. E. Reeves, W. T. Stevens, P. Herrmann, H. Cao and E. Lau. Convalescent plasma for COVID-19: A single center prospective experience with serial antibody measurements and review of the literature. Pathogens 11(9):958. 2022. PMID: 36145390. (06/2022)
  • Miles, F. L., M. J. Orlich, A. Mashchak, P. D. Chandler, J. W. Lampe, P. Duerksen-Hughes, and G. E. Fraser. The biology of veganism: Plasma metabolomics analysis reveals distinct profiles of vegans and non-vegetarians in the Adventist Health Study-2 cohort. Nutrients 14:709, 2022. PMID: 35277064. (02/2022)
  • Chitsike, L., C. H. Yuan, A. Roy, K. Boyle and P. J. Duerksen-Hughes. A high-content AlphaScreenTM identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas. Oncotarget 12:549-561, 2021. PMID: 33796223. (11/2021)
  • M. Katerji and P. J. Duerksen-Hughes. DNA damage in cancer development: special implications in viral oncogenesis. Am. J. Cancer Res. 11:3956-3979, 2021. PMID 34522461. (11/2021)
  • L. Chitsike and P. J. Duerksen-Hughes. Targeted therapy as a potential de-escalation strategy in locally advanced HPV-associated oropharyngeal cancer: A literature review. Front. Oncology 11:1730412, 2021. PMID: 34490123. (11/2021)
  • L. Chitsike and P. Duerksen-Hughes. Keep out! SARS-CoV-2 entry inhibitors: their role and utility as COVID-19 therapeutics. Virol. J. 18:154, 2021. PMID: 34301275. (11/2021)
  • L. Chitsike and P. J. Duerksen-Hughes. PPI modulators of E6 as potential targeted therapeutics for cervical cancer: Progress and challenges in targeting E6. Molecules 26:3004, 2021. PMID: 34070144. (11/2021)
  • M. Katerji and P. Duerksen-Hughes. DNA damage in cancer development: Special implications in viral oncogenesis. American J of Cancer Research. 11:3956-3979, 2021. PMID: 34522461. (11/2021)
  • Chitsike, L., J. Krstenansky and P. J. Duerksen-Hughes. ACE2:S1 RBD Interaction-targeted peptides and small molecules as potential COVID-19 therapeutics. Adv. Pharmacol. Sci. 2021:1828792, 2021. PMID: 34746794. (11/2021)
  • Chitsike, L., C. H. Yuan, A. Roy, K. Boyle and P. J. Duerksen-Hughes. A high-content AlphaScreenTM identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas. Oncotarget 12:549-561, 2021. PMID: 33796223. (04/2021)
  • L. Chitsike and P. J. Duerksen-Hughes. The potential of immune checkpoint blockade in Cervical Cancer: Can combinatorial regimens maximize response? A review of the literature. Current Treatment Options in Oncology 21:95, 2020. PMID: 33025260. (04/2021)
  • M. Katerji and P. Duerksen-Hughes. DNA damage in cancer development: Special implications in viral oncogenesis. American J of Cancer Research. (In Press), 2021. (04/2021)
  • Liu, T., N. M Gatto, Z. Chen, H. Qiu, G. Lee, P. Duerksen-Hughes, G. Fraser and C. Wang. Vegetarian diets, circulating miRNA expression and healthspan in subjects living in the Blue Zone. Precision Clinical Medicine 3:245-259, 2020. PMID: 33391847. (12/2020)
  • Filippov, V., K. Jaceldo-Siegl, A. Eroshkin, V. Loskutov, X. Chen, C. Wang and P. J. Duerksen-Hughes. Methylomes in vegans versus pescatarians and nonvegetarians. Epigenomes 4:28, 2020. PMID: 33768971. (12/2020)
  • Miles, F.J., A. Mashchak, V. Filippov, M. J. Orlich, P. Duerksen-Hughes, X. Chen, C. Wang, K. Siegmund and G. E. Fraser. DNA methylation profiles of vegans and non-vegetarians in the Adventist Health Study-2 Cohort. Nutrients 12:E3697, 2020. PMID: 33266012. (12/2020)
  • Katerji, M., M. Filippova, Y. C. Wongworawat, S. Siddighi, S. Bashkirova and P. J. Duerksen-Hughes. Oxidative stress markers in patient-derived non-cancerous cervical tissues and cells. Sci. Rep. 10:19044, 2020. PMID: 33149215. (12/2020)
  • Mirshahidi, S., R. de Necochea-Campion, A. Moretta, N. L. Williams, M. E. Reeves, S. Otoukesh, H. R. Mirshahidi, S. Khosrowpour, P. Duerksen-Hughes, and L. M. Zuckerman. Inhibitory Effects of Indomethacin in human MNNG/HOS osteosarcoma cell line in vitro. Cancer Invest. 38:23-36, 2020. PMID: 31770037. (12/2020)
  • P. Sherchan, F. Miles, M. Orlich, G. Fraser, J. H. Zhang, K. Talbot and P. J. Duerksen-Hughes. Effects of lifestyle factors on cognitive resilience: Commentary on “What this sunny, religious town in California teaches us about living longer. Translational Stroke Research 11:161, 2020. PMID: 32062815. (02/2020)
  • Mirshahidi, S., R. de Necochea-Campion, A. Moretta, N. L. Williams, M. E. Reeves, S. Otoukesh, H. R. Mirshahidi, S. Khosrowpour, P. Duerksen-Hughes, and L. M. Zuckerman. Inhibitory Effects of Indomethacin in human MNNG/HOS osteosarcoma cell line in vitro. Cancer Invest. 38:23-36, 2020. PMID: 31770037. (02/2020)
  • M. Katerji, M. Filippova and P. Duerksen-Hughes. Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field. Oxidative Medicine and Cellular Longevity 2019:1279250, 2019. PMID: 30992736. (10/2019)
  • Knutsen, R., V. Filippov, S. F. Knutsen, G. E. Fraser, J. Lloren, D. Juma and P. Duerksen-Hughes. Cold parenting is associated with cellular aging in offspring: A retrospective study. Biological Psychology, 2019. In Press. PMID: 31014776   (07/2019)
  • Hu, J., S. Mirshahidi, A. Simental, S. C. Lee, P. A. De Andrade Filho, N. R. Peterson, P. Duerksen-Hughes and X. Yuan. Cancer stem cell self-renewal as a therapeutic target in human oral cancer. Oncogene, In Press, 2019. PMID: 30936460. (07/2019)
  • Mirshahidi, S., A. Simental, S. C. Lee, P. A. De Andrade, N. R. Peterson, W. Cao, R. Necochea-Campion, H. Yang, P. Duerksen-Hughes, and X. Yuan. Subpopulations of cancer stem cells found in papillary thyroid carcinoma. Exp. Cell Res. 362:515-524, 2018. PMID: 29274322. (07/2018)
  • Evans, W., M. Filippova, V. Filippov, S. Bashkirova, G. Zhang, M. E. Reeves and P. J. Duerksen-Hughes. Overexpression of HPV16 E6* Alters b-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells. Cancer Genomics & Proteomics 13:259-73, 2016. PMID: 27365376. (10/2016)
  • Chen Wongworawat, Y., M. Filippova, V. M. Williams, V. Filippov, P. J. Duerksen-Hughes. Chronic oxidative stress increases the integration frequency of foreign DNA and human papillomavirus 16 in human keratinocytes.  Am. J. Cancer Research 6:684-680, 2016. PMID: 27186429. (02/2016)
  • Yuan, C.-H., M. Filippova, J. L. Krstenansky and P. Duerksen-Hughes. Flavonol and Imidazole Derivatives Block HPV16 E6 Activities and Reactive Apoptotic Pathways in HPV+ Cells. Cell Death & Disease 7:2060-2072, 2016. PMID: 26794656. (01/2016)
  • S. N. Whang, M Filippova and P. Duerksen-Hughes. Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer. Viruses 7:5040-5065, 2015. (09/2015)
  • Tolen, J. A., P. Duerksen-Hughes, K. Lau, and P. J. Chan.  Selenium attenuate HPV-18 associated apoptosis in embryo-derived trophoblastic cells but not inner cell mass in vitro. Int. J. Reprod. Med.,2015:562567, 2015. PMID: 26345191. (07/2015)
  • Carr, K. R., Y. J. Ioffe, M. Filippova, P. Duerksen-Hughes, and P. J. Chan. Combined ultrasound-curcumin treatment of human cervical cancer cells. European J. of Obstetrics & Gynecology and Reproductive Biology 193:96-101, 2015.  PMID: 26262768 (01/2015)
  • Y. Chen, V. Williams, M. Filippova, V. Filippov and P. J. Duerksen-Hughes. Viral carcinogenesis: factors inducing DNA damage and virus integration. Cancers (Basel) 6:2156-86, 2014. PMID: 2540830. (12/2014)
  • Filippova, M., V. Filippov, W. M. Williams, K. Zhang, A. Kokoza, S. Bashkirova and P. J. Duerksen-Hughes. Cellular levels of oxidative stress affect the response of cervical cancer cells to chemotherapeutic agents. Biomed. Res. Int. 2014:57659, 2014. PMID: 25478571 (12/2014)
  • Hsu, H. W., R. de Necochea-Campion, V. Williams, P. J. Duerksen-Hughes, A. A. Simental, Jr., R. L. Ferris, C. S. Chen and S. Mirshahidi. Linifanib (ABT-869) enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells. Oral Oncol. 50:662-669, 2014. PMID: 24735547. (04/2014)
  • Yu, Y., J. Fuscoe, C. Hao, C. Guo, M. Jia, T. Qing, D. Bannon, L. Lancashire, W. Bao, T. Du, H. Luo, Z. Su, W. Jones, C. Moland, W. Branham, F. Qian, B. Ning, Y. Li, H. Hong, L. Guo, N. Mei, T. Shi, K. Wang, Y. Nikolsy, R. Wolfinger, S. Walker, P. Duerksen-Hughes, C. Mason, W. Tong, J. Thierry-Mieg, D. Thierry-Mieg, L. Shi and C. Wang. A rat RNA-Seq transcriptomic Bodymap across eleven organs and four developmental stages”.  Nature Communications.  5:3230, 2014. PMID: 24510058. (04/2014)
  • Filippova, M., W. Evans, R. Aragon, V. Filippov, V. Williams, L. Hong, M. E. Reeves, and P. J. Duerksen-Hughes. The Small splice variant of HPV16 E6, E6*, reduces tumor formation in cervical carcinoma xenografts. Virology. 450-451:153-164, 2014. PMID: 24503078.   (03/2014)
  • Gao, X., L. Kong, X. Lu, G. Zhang, L. Chi, Y. Jiang, Y. Wu, C. Yan, P. Duerksen-Hughes, X. Zhu and J. Yang. Paraspeckle Protein 1 (PSPC1) is Involved in the Cisplatin Induced DNA Damage Response – Role in G1/S Checkpoint. PLOS ONE. 9:e97174. 2014. (07/2013)
  • Ju L, Zhang G L, Zhang C, Sun L, Jiang Y, . . . Yang J. (2013). Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation. Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 753(1), 54-64. PMID: 23416234. (04/2013) (link)
  • Whitaker E L, Filippov V A, & Duerksen-Hughes P J. (2012). Interleukin 24: Mechanisms and therapeutic potential of an anti-cancer gene. Cytokine & Growth Factor Reviews, 23(6), 323-331. (12/2012) (link)
  • Yuan C H, Filippova M, & Duerksen-Hughes P. (2012). Modulation of Apoptotic Pathways by Human Papillomaviruses (HPV): Mechanisms and Implications for Therapy. Viruses-Basel, 4(12), 3831-3850. (12/2012) (link)
  • Jiang Y, Zhang X Y, Sun L, Zhang G L, Duerksen-Hughes P, Zhu X Q, & Yang J. (2012). Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2-and mitochondria-associated pathway. Environmental Toxicology and Pharmacology, 34(3), 694-704. (11/2012) (link)
  • Gan T E, Xiao S P, Jiang Y, Hu H, Wu Y H, . . . Yang J. (2012). Effects of Benzo(a)pyrene on the Contractile Function of the Thoracic Aorta of Sprague-dawley Rats. Biomedical and Environmental Sciences, 25(5), 549-556. PMID: 23122312. (10/2012) (link)
  • Jiang, Y., X.-Y. Zhang, L. Sun, G.-L. Zhang, P. Duerksen-Hughes, X.-Q. Zhu and J. Yang.  Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a Caspase 2- and mitochondria-associated pathway.  Environmental Toxicology and Pharmacology, 34:694-704, 2012. PMID: 23117069. (07/2012)
  • Whitaker, E. L., V. A. Filippov and P. J. Duerksen-Hughes. Interleukin 24:  Mechanisms and therapeutic potential of an anti-cancer gene.  Cytokine and Growth Factor Reviews, 23:323-331, 2012. PMID: 22981288.   (07/2012)
  • Gan, T. E., S. P. Xiao, Y. Jiang, H. Hu, Y. H. Wu, P. J. Duerksen-Hughes, J. T. Sheng and J. Yang.  Effects of benzo(a)pyrene on the contractile function of the thoracic aorta of Sprague-dawley rats. Biomed. Environ. Sci., 25:373-380, 2012. PMID: 23122312. (07/2012)
  • C.-H. Yuan, M. Filippova and P. J. Duerksen-Hughes. Modulation of Apoptotic Pathways by HPV:  Mechanisms and Implications for Therapy. Viruses, 4:3831-3850, 2012.  (07/2012)
  • Ju, L., G. Zhang, C. Zhang, L. Sun, Y. Jiang, C. Yan, P. J. Duerksen-Hughes, X. Zhang, X. Zhu, F. F. Chen and J. Yang. Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation. Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 753:54-64, 2013. PMID: 23416234. (07/2012)
  • Yuan C H, Filippova M, Tungteakkhun S S, Duerksen-Hughes P J, & Krstenansky J L. (2012). Small molecule inhibitors of the HPV16-E6 interaction with caspase 8. Bioorganic & Medicinal Chemistry Letters, 22(5), 2125-2129. (03/2012) (link)
  • Yan C L, Chen Z J, Li H R, Zhang G L, Li F, . . . Yang J. (2012). Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 731(1-2), 75-84. (03/2012) (link)
  • Haynes, T.-A. S., V. Filippov, M. Filippova, J. Yang, K. Zhang, and P. J. Duerksen-Hughes.  DNA damage induces down-regulation of UDP-Glucose Ceramide Glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.  BBA – Molecular and Cell Biology of Lipids, 1821:943-953, 2012.  PMID:  22349266 (02/2012) (link)
  • Filippov, V., M.A. Song, K. Zhang, H. V. Vinters, S. Tung, W. M. Kirsch, J. Yang, and P. J. Duerksen-Hughes.  Increased Ceramide in brains with Alzheimer’s and other neurodegenerative diseases. Journal of Alzheimer’s Disease, 29:537-547, 2012.  PMID:  22258513 (01/2012) (link)
  • Whitaker E L, Filippov V, Filippova M, Guerrero-Juarez C F, & Duerksen-Hughes P J. (2011). Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells. Cytokine, 56(2), 272-281. (11/2011) (link)
  • Zhang, G., L. Sun, X. Lu, Z. Chen, P. J. Duerksen-Hughes, H. Hu, X. Zhu and J. Yang.  Cisplatin treatment leads to changes in nuclear protein and microRNA expression. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 746:66-77, 2012.   (07/2011)
  • Haynes, T.-A. S., V. Filippov, M. Filippova, J. Yang, K. Zhang, and P. J. Duerksen-Hughes.  DNA damage induces down-regulation of UDP-Glucose Ceramide Glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.  BBA – Molecular and Cell Biology of Lipids, 1821:943-953, 2012.  PMID:  22349266   (07/2011 - 06/2012)
  • Yan, C., Z. Chen, H. Li, G. Zhang, F. Li, P. J. Duerksen-Hughes, X. Zhu, and J. Yang.  Nuclear proteome analysis of benzo(a)pyrene-treated HeLa cells. Mutat. Res. 731:75-84, 2012.  PMID:  22138005     (07/2011 - 06/2012)
  • Gan, T.-E., S.-P. Xiao, Y. Jiang, H. Hu, Y.-H. Wu, P. J. Duerksen-Hughes, J.-Z. Sheng, and J. Yang.  Effects of beno(a)pyrene on contractile functions of thoracic aorta of Sprague-Dawley rats. Biomedical and Environmental Sciences, 25:549-556, 2012.  PMID: 23122312 (07/2011 - 06/2012)
  • Filippov, V., M.A. Song, K. Zhang, H. V. Vinters, S. Tung, W. M. Kirsch, J. Yang, and P. J. Duerksen-Hughes.  Increased Ceramide in brains with Alzheimer’s and other neurodegenerative diseases. Journal of Alzheimer’s Disease, 29:537-547, 2012.  PMID:  22258513 (07/2011 - 06/2012)
  •  Yuan, C.-H., M. Filippova, S. S. Tungteakkhun, P. J. Duerksen-Hughes and J. L. Krstenansky. Small molecule inhibitors of the HPV16-E6 interaction with caspase 8. Bioorganic and Medicinal Chemistry Letters22:2125-2129, 2012.  PMID:  22300659                (07/2011)
  •  K. Zhang, T.-A. S. Haynes, M. Filippova, V. Filippov and P. J. Duerksen-Hughes.  Quantification of ceramide levels in mammalian cells by high performance liquid chromatography coupled to tandem mass spectrometry with multiple-reaction-monitoring mode (HPLC-MS/MS-MRM).  Analytical Methods 3:1193-1197, 2011. (07/2011)
  •  Whitaker, E. L., V. Filippov, M. Filippova, C. V. Guerrero-Jugarez, and P. J. Duerksen-Hughes.  Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells.  Cytokine 56:272-281, 2011.  PMID:  21843952   (07/2011 - 06/2012)
  • Zhang K L, Haynes T A S, Filippova M, Filippov V, & Duerksen-Hughes P J. (2011). Quantification of ceramide levels in mammalian cells by high performance liquid chromatography coupled to tandem mass spectrometry with multiple-reaction-monitoring mode (HPLC-MS/MS-MRM). Analytical Methods, 3(5), 1193-1197. (05/2011) (link)
  • Xiong, L., A. Darwanto, S. Sharma, J. Herring, S. Hu, M. Filippova, V. Filippov, Y. Wang, C.-S. Chen, P. J. Duerksen-Hughes, L. C. Sowers, K. Zhang.  Mass spectrometric studies on epigenetic interaction networks in cell differentiation.  J. Biol. Chem286:13657-68, 2011.  PMID: 21335548 (04/2011) (link)
  • Mujumdar, P., P. J. Duerksen-Hughes, A. F. Firek and D. A. Hessinger.  Long-term, Progressive Aerobic Training Increases Adiponectin in Middle-aged, Overweight, Untrained Males and Females.  Scan. J. Clin. Lab. Invest.  71:101-107, 2011.  PMID:  21271804 A (04/2011) (link)
  • Williams V M, Filippova M, Soto U, & Duerksen-Hughes P J. (2011). HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress. Future Virology, 6(1), 45-57. (01/2011) (link)
  • Xiong, L., A. Darwanto, S. Sharma, J. Herring, S. Hu, M. Filippova, V. Filippov, Y. Wang, C.-S. Chen, P. J. Duerksen-Hughes, L. C. Sowers, K. Zhang.  Mass spectrometric studies on epigenetic interaction networks in cell differentiation.  J. Biol. Chem286:13657-68, 2011.  PMID: 21335548 (2011) (link)
  • Yan, C., J. Lu, G. Zhang, T. Gan, Q. Zeng, Z. Shao, P. J. Duerksen-Hughes, and J. Yang.  Benzo[a]pyrene Induces Complex H2AX Phosphorylation Patterns by Multiple Kinases Including ATM, ATR, and DNA-PK.  Toxicology In Vitro 25:91-99, 2011.  PMID:  20888899 (2011) (link)
  • Xiong, L., A. Darwanto, S. Sharma, J. Herring, S. Hu, M. Filippova, V. Filippov, Y. Wang, C.-S. Chen, P. J. Duerksen-Hughes, L. C. Sowers, K. Zhang.  Mass spectrometric studies on epigenetic interaction networks in cell differentiation.  J. Biol. Chem.  286:13657-68, 2011.    PMID:  21335548   (07/2010 - 06/2011)
  •  Mujumdar, P., P. J. Duerksen-Hughes, A. F. Firek and D. A. Hessinger.  Long-term, Progressive Aerobic Training Increases Adiponectin in Middle-aged, Overweight, Untrained Males and Females.  Scan. J. Clin. Lab. Invest.  71:101-7, 2011. PMID:  21271804   (07/2010 - 06/2011)
  •  Yan, C., J. Lu, G. Zhang, T. Gan, Q. Zheng, Z. Shao, P. J. Duerksen-Hughes, and J. Yang.  Benzo[a]pyrene Induces Complex H2AX Phosphorylation Patterns by Multipole Kinases Including ATM, ATR, and DNA-PK.  Toxicology In Vitro 25:91-91, 2011.  PMID:  20888899   (07/2010 - 06/2011)
  • Williams, V. M., M. Filippova, U. Soto and P. J. Duerksen-Hughes.  HPV-DNA Integration and Carcinogenesis:  Putative Roles for Inflammation and Oxidative Stress.  Future Virology, 6(1): 45-57, 2011.  PMID:  21318095 (07/2010)
  • Tungteakkhun, S. S., M. Filippova, N. Fodor and P. J. Duerksen-Hughes.  The Full Length Isoform of HPV 16 E6 and its Splice Variant E6* Bind to Different Sites on Procaspase 8 DED.  J. Virol. 84:1453-1463, 2010.  PMID:  19906919 (02/2010) (link)
  • Yan, C., W. Wu, H. Li, G. Zhang, P. J. Duerksen-Hughes and J. Yang.  Benzo[a]pyrene Treatment Leads to Changes in Nuclear Protein Expression and Alternative Splicing.  Mutat. Res. 686:47-56, 2010.  PMID:  20097212 A (2010) (link)
  • Wu, W., C. Yan, T. Gan, Z. Chen, X. Lu, P. J. Duerksen-Hughes, X. Zhu and J. Yang.  Nuclear Proteome Analysis of Cisplatin-treated HeLa Cells.  Mutat. Res. 691:1-8, 2010.  PMID:  20540955 (2010) (link)
  •  Tungteakkhun, S. S., M. Filippova, N. Fodor and P. J. Duerksen-Hughes.  The Full-Length Isoform of Human Papillomavirus 16 E6 and its Splice Variant E6* Bind to Different Sites on the Procaspase 8 Death Effector Domain.  J. Virology 84:1453-1463, 2010. PMID:  19906919   (07/2009 - 06/2010)
  •  Wu, W., C. Yan, T. Gan, Z. Chen, X. Lu, P. J. Duerksen-Hughes, X. Zhu and J. Yang.  Nuclear Proteome Analysis of Cisplatin-Treated HeLa Cells.  Mutation Research 2010.  PMID:  20540955   (07/2009 - 06/2010)
  •  Yan, C., W. Wu, H. Li, G. Zhang, P. J. Duerksen-Hughes, X. Zhu and J. Yang.  Benzo[a]pyrene Treatment Leads to Changes in Nuclear Protein Expression and Alternative Splicing.  Mutat. Res. 686:47-56, 2010.  PMID:  20097212   (07/2009 - 06/2010) (link)
  • Filippova, M., V. A. Filippov, M. Kagoda, T. Garnett, N. Fodor and P. J. Duerksen-Hughes.  Complexes of Human Papillomavirus 16 E6 Proteins Form Pseudo-DISC Structures During TNF-Medicated Apoptosis.  J. Virol83:210-227, 2009.  PMID:  18842714 (01/2009) (link)
  •  Filippova, M., V. A. Filippov, M. Kagoda, T. Garnett, N. Fodor and P. J. Duerksen-Hughes.  Complexes of Human Papillomavirus 16 E6 Proteins Form Pseudo-DISC Structures During TNF-Mediated Apoptosis.  J. Virology 83:210-227, 2009.  PMID:  18842714   (07/2008 - 06/2009)
  •  Tungteakkhun, S. S., M. Filippova, J. W. Neidigh, N. Fodor, and Penelope J. Duerksen-Hughes.  The Interaction between Human Papillomavirus Type 16 and FADD is Mediated by a Novel E6 Binding Domain.  J. Virol. 82:9600-9614, 2008.  PMID: 18632871 (07/2008)
  •  Tungteakkhun, S. S. and P. J. Duerksen-Hughes.  Cellular binding partners of the human papillomavirus E6 protein.  Arch. Virol. 153:397-408, 2008.  PMID:  18172569 (07/2007)
  •  Filippov, V., E. L. Schmidt, M. Filippova and P. J. Duerksen-Hughes. Splicing and splice factor SRp55 participate in the response to DNA damage by changing isoform ratios of target genes.  Gene.  420:34-41, 2008.  PMID:  18571879 (07/2007)
  •  Haynes, T.-A S., P. J. Duerksen-Hughes, M. Filippova, V. Filippov and K. Zhang.  C(18) Ceramide Analysis in Mammalian Cells Employing Reversed-Phase High Performance Liquid Chromatography Tandem Mass Spectrometry.  Analytical Biochemistry378:80-86, 2008.  PMID:  18423390 (07/2007)
  • Filippov, V., M. Filippova and P. J. Duerksen-Hughes.  The Early Response to DNA Damage Can Lead to Activation of Alternative Splicing Activity Resulting in CD44 Splice Pattern Changes.   Cancer Research67:7621-7630, 2007.  PMID:  17699766. (07/2007)
  • Filippova, M., M. M. Johnson, M. Bautista, V. Filippov, N. Fodor, S. S. Tungteakkhun, K. Williams and P. J. Duerksen-Hughes.  The Large and Small Isoforms of HPV 16 E6 Bind to and Differentially Affect Procaspase 8 Stability and Activity.  J. Virology.  81:4116-4129, 2007.  PMID:  17267478 (07/2006) (link)
  • Theodore O. Garnett, Maria Filippova and Penelope J. Duerksen-Hughes. "Accelerated Degradation of FADD and Procaspase 8 in Cells Expressing Human Papillomavirus 16 E6 Impairs TRAIL-mediated Apoptosis." Cell Death and Differentiation 13. (2006): 1915-1926. PMID: 16528386. (07/2006) (link)
  • Garnett, T. O., M. Filippova and P. J. Duerksen-Hughes.  Bid is Cleaved Upstream of Caspase-8 Activation During TRAIL-Mediated Apoptosis in Human Osteosarcoma Cells.  Apoptosis12:1299-1315, 2007.   PMID:  17431792   (07/2006) (link)
  • Filippov, V., M. Filippova and P. J. Duerksen-Hughes.  The Early Response to DNA Damage Can Lead to Activation of Alternative Splicing Activity Resulting in CD44 Splice Pattern Changes.   Cancer Research67:7621-7630, 2007.  PMID:  17699766 (06/2006) (link)
  • Modulation of Apoptosis by Human Papillomavirus (HPV) Oncoproteins.  Archives of Virology, 151:2321-2335, 2006.  PMID:  16862386 (07/2005) (link)
  • Filippova, M., T. A. Brown-Bryan, C. A. Casiano and P. J. Duerksen-Hughes.  The Human Papillomavirus 16 E6 Protein Can Render Cells Either Sensitive or Resistant to TNF:  Effect of Dose.  Cell Death and Differentiation. 12:1622-1635, 2005.  PMID:  15933739 (07/2004) (link)
  • Filippova, M., Parkhurst, L. and P. J. Duerksen-Hughes.  The Human Papillomavirus 16 E6 Protein Binds to Fas-Associated Death Domain and Protects Cells from Fas-Triggered Apoptosis.  J. Biol. Chem. 279:25729-25744, 2004.  PMID:  15073179 (07/2003) (link)
  • Jun Yang, Zheng-Ping Xu, Yun Huang, Hope E. Hamrick, Penelope J. Duerksen-Hughes, Ying-Nian Yu. "ATM and ATR: Sensing DNA Damage." World J. Gastroenterology 10.2 (2004): 155-160. PMID: 14716813. (07/2003) (link)
  • Yang, J., Y. Yu, S. Sun and P. J. Duerksen-Hughes.  Ceramide and Other Sphingolipids in Cellular Response.  Cell Biochemistry and Biophysics. 40:323-350, 2004.  PMID:  15211031 (07/2003) (link)
  • Yang, J., Z.-P. Xu, Y. Huang, H. E. Hamrick, P. J. Duerksen-Hughes and Y.-N. Yu.  ATM and ATR:  Sensing DNA Damage.  World J. Gastroenterol. 10:155-160, 2004.  PMID:  14716813 (07/2002) (link)
  • Filippova, M. and P. J. Duerksen-Hughes.  Inorganic and Dimethylated Arsenic Species Induce Cellular p53.  Chemical Research in Toxicology 16:423-431, 2003.  PMID:  12641444 (07/2002) (link)
  • Jun Yang, Yingnian Yu and Penelope J. Duerksen-Hughes. "Protein Kinases and their Involvement in the Cellular Responses to Genotoxic Stress." Mutation Research 543. (2003): 31-58. PMID: 12510016. (07/2002) (link)
  • Filippova, M., H. Song, J. L. Connolly, T. S. Dermody and P. J. Duerksen-Hughes. The Human Papillomavirus 16 E6 Protein Binds to TNF R1 and Protects Cells from TNF-Triggered Apoptosis.  J. Biol. Chem. 277:21730-21739, 2002.  PMID:  11934887 (07/2001) (link)
  • Yang, J. and P. J. Duerksen-Hughes. Activation of a p53 -Independent, Sphingolipid-Mediated Cytolytic Pathway in p53-Negative Mouse Fibroblast Cells Treated with N-methyl-N-nitro-N-nitrosoguanidine. J. Biol. Chem. 276:27129-27135, 2001.  PMID:  11369765 (07/2000) (link)
  • Penelope J. Duerksen-Hughes, Jun Yang and Stephanie B. Schwartz. "HPV 16 E6 Blocks TNF-Mediated Apoptosis in Mouse Fibroblast LM Cells." Virology 264. (1999): 55-65. PMID: 10544129. (07/1998) (link)
  • Duerksen-Hughes, P. J., J. Yang and 0. Ozcan. p53-Induction as a Genotoxic Test for Twenty-five Chemicals Undergoing in vivo Carcinogenicity Testing. Env. Health Perspectives 107:805-812, 1999.  PMID:  10504146 (07/1998) (link)
  • Yang, J. and P. J. Duerksen-Hughes. A New Approach to Identifying Genotoxic Carcinogens: p53-Induction as an Indicator of Genotoxic Damage. Carcinogenesis 19(6):1117-1125, 1998.  PMID:  9667752 (07/1997) (link)

Books and Chapters

  • W. Evans, M. Filippova, R. Swensen and P. Duerksen-Hughes. Modern Molecular and Clinical Approaches to Eradicate HPV-Mediated Cervical Cancer, Chapter 11,  Human Papillomavirus and Related Diseases from Bench to Bedside: A Diagnostic and Preventative Perspective. D. Vanden Broeck, editor; ISBN 978-953-51-1072-9, 2013. (07/2012)