Publications

Abstract

• Vesoulis Z, Hopper A, Fairchild K, Zanelli S, Chalak L, Noroozi M, Liu J, Chock V. A phase-II trial of targeted cerebral near-infrared spectroscopy using standardized treatment guidelines to improve brain oxygenation in preterm infants (Box-II): A study protocol. Contemporary Clinical Trials 120 (2022)106886. https://doi.org/10.1016/j.eet.2022.106886. (06/2023)
• Singh G, Hopper A, Wilson C, Pichon P, Razzouk A, martens T, Tan J, Carter H, Tinsley L and Chandnani H. 2022. 406: Perioperative Non-Invasive Neuromonitoring in Infants with Congenital Heart Disease. Critical Care Medicine, 50(1), p. 191. Presented at SCCM Conference, April 2022 (04/2022)
• Agrawal P, Magsipoc A, Kang Y, Jung P, Banerji AI, Deming DD, Hopper AO. Presented at the Western Medical Research Conference, January 25, 2019. 10.1136/jim-2018-000939.197. (01/2019)
• High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele.  Hutson S, Baerg J, Deming D, St Peter SD, Hopper A, Goff DA. Neonatology, 2017 July 14;112(3):281-286. PMD: 28704835. Doi 10.1159/000477535.  (07/2017)
• Pulmonary Hypertension predicts mortality in infants with omphalocele. Baerg JE, Thorpe DL, Sharp NE, Ramlogan SR, Hutson SM, Goff DA, Hopper AO, St. Peter SD. J Neonatal Perinatal Med. 2015;8(4):333-8. Doi 10.3233/NPM-15915011.  (10/2015)
• Hutson S, Baerg J, Ramlogan S, Woelk A, Drake W, . . . Goff D. (2013). High Prevalence of Pulmonary Hypertension Complicates Care of Infants With Omphalocele. Circulation, 128(22), 2. (11/2013)
• Jones J, Ninnis J R, Hopper A O, Ibrahim Y, Merritt T A, . . . Blood A B. (2013). Nitrite and nitrate concentrations and metabolism in breast milk, artificial milk, and parenteral nutrition of term and preterm infants. Nitric Oxide-Biology and Chemistry, 31, S28-S29. (04/2013) (link)
• Hutson S, Baerg J, Woelk J, Lavery A, Hopper A, & Goff D A. (2013). PULMONARY HYPERTENSION IN INFANTS WITH OMPHALOCELE. Journal of Investigative Medicine, 61(1), 120-120. (01/2013)
• Adams K K, Goldstein M, Ninnis J, Hopper A, & Deming D. (2012). USE OF AN OXYGEN SATURATION HISTOGRAM INCREASES TIME INFANTS ARE WITHIN TARGET SATURATION RANGE. Journal of Investigative Medicine, 60(1), 160-161. (01/2012)
• Kanady J, Ninnis J, Hopper A, Ibrahim Y, Merritt T A, Power G, & Blood A. (2011). Nitrite and nitrate concentrations and metabolism in breast milk, infant formula, and saliva of term and preterm infants. Nitric Oxide-Biology and Chemistry, 24, S20-S20. (05/2011) (link)
• Kanady J A, Hopper A O, Ninnis J R, Aruni W, Power G G, & Blood A B. (2011). BACTERIAL NITRATE REDUCTION IN SALIVA OF NEWBORN INFANTS. Journal of Investigative Medicine, 59(1), 170-171. (01/2011)
• Hopper A, Schroeder H, Terry M, Merrill-Henry J, Power G, & Blood A. (2009). Production of nitric oxide from nitrite in the lung. Nitric Oxide-Biology and Chemistry, 20, S30-S30. (06/2009)
• Kanady J, Ibrahim Y, Hopper A O, Ninnis J R, Power G G, & Blood A B. (2009). NITRITE CONCENTRATION IN SALIVA AND DIET OF TERM AND PRETERM INFANTS. Journal of Investigative Medicine, 57(1), 131-131. (01/2009)
• Ibrahim Y A, Ninnis J R, Hopper A O, Power G G, & Blood A B. (2009). EFFECT OF INHALED NITRIC OXIDE ON PLASMA NITRITE CONCENTRATIONS IN INFANTS WITH PERSISTENT PULMONARY HYPERTENSION. Journal of Investigative Medicine, 57(1), 128-128. (01/2009)
• Hopper A, Ninnis J, Mulla N, Deming D, Terry M, Moore P, & Peverini R. (2009). PERSISTENT PULMONARY HYPERTENSION IN VERY LOW BIRTH WEIGHT INFANTS: A ROLE FOR INHALED NITRIC OXIDE?. Journal of Investigative Medicine, 57(1), 128-129. (01/2009)
• (PEER REVIEWED) Conahey G, Kirby LS, Terry MH, Hopper AO, Ninnis JR, Power GG, Blood AB. "Cerebrospinal fluid concentration of Nitrite following Administration of Inhaled Nitric Oxide in Newborn Lambs." Pediatric Research 61.11 (2007): -. (05/2007)
• (PEER REVIEWED) Chong JK, Power GG, Kirby LS, Conahey G, Hopper AO, Blood AB. "Effects of oxygenation-deoxygenation cycling on nitrite metabolism in blood in vivo and ex vivo." Pediatric Research 61.11 (2007): -. (05/2007)
• (PEER REVIEWED) Morkos A, Hopper A, Deming D, Yellon S, Wycliffe N, Ashwal S, Peverini R, Angeles D. "Elevated Total Peripheral Leukocyte Count may Identify Risk for Abnormal MRI Imagain and Neurologic Disability in Infants with Hypoxic-Ischemic Encephalopathy." Pediatric Research 57.2665 (2005): 1000-1000. (01/2005)

Scholarly Journals--Published

• Hansen ML, Pellicer A, Hyttel-Sørensen S, Ergenekon E, Szczapa T, Hagmann C, Naulaers G, Mintzer J, Fumagalli M, Dimitriou G, Dempsey E, Tkaczyk J, Cheng G, Fredly S, Heuchan AM, Pichler G, Fuchs H, Nesargi S, Hahn GH, Piris-Borregas S, Širc J, Alsina-Casanova M, Stocker M, Ozkan H, Sarafidis K, Hopper AO, Karen T, Rzepecka-Weglarz B, Oguz SS, Arruza L, Memisoglu AC, Del Rio Florentino R, Baserga M, Maton P, Truttmann AC, de Las Cuevas I, Agergaard P, Zafra P, Bender L, Lauterbach R, Lecart C, de Buyst J, El-Khuffash A, Curley A, Vaccarello OO, Miletin J, Papathoma E, Vesoulis Z, Vento G, Cornette L, Lopez LS, Yasa B, Klamer A, Agosti M, Baud O, Mastretta E, Cetinkaya M, McCall K, Zeng S, Hatzidaki E, Bargiel A, Marciniak S, Gao X, Huijia L, Chalak L, Yang L, Rao SA, Xu X, Gonzalez BL, Wilinska M, Yin Z, Sadowska-Krawczenko I, Serrano-Viñuales I, Krolak-Olejnik B, Ybarra MM, Morales-Betancourt C, Korcek P, Teresa-Palacio M, Mosca F, Hergenhan A, Koksal N, Tsoni K, Kadri MM, Knöpfli C, Rafinska-Wazny E, Akin MS, Nordvik T, Peng Z, Kersin SG, Thewissen L, Alarcon A, Healy D, Urlesberger B, Bas M, Baumgartner J, Skylogianni E, Karadyova V, Valverde E, Bergon-Sendin E, Kucera J, Pisoni S, Wang L, Smits A, Sanchez-Salmador R, Rasmussen MI, Olsen MH, Jensen AK, Gluud C, Jakobsen JC, Greisen G. Cerebral Oximetry Monitoring in Extremely Preterm Infants. N Engl J Med. 2023 Apr 20;388(16):1501-1511. doi: 10.1056/NEJMoa2207554. PMID: 37075142. (04/2023)
• Banerji A, Hopper A, Kadri M, Harding B, Phillips R. Creating a small baby program: a single center’s experience. J Perinatol. 2022 Feb;42(2):277-280.doi: 10.1038/s41372-021-01247-8. PMID 34974538. (02/2022)
• Angeles DM, BoskovicDS, DemingD, Hopper A, Peverini R, Czynski A, Hock E, Phillips R, Tan JB, Camberos V, Bahjri K, Pegis P, Goldstein M, Truong G, Fayard E. A pilot study on the biochemical effects of repeated administration of 24% oral sucrose vs. 30% oral dextros on urinary markers of adenosine triphosphate degradation. J Perinatol. 2021 Dec;41(12):2761-2765. Doi: 10.1038/s41372-021-01239-8. Epub 2021 Oct. 20 PMID: 34671099. (10/2021)
• Tan JBC, Dunbar J, Hopper AO, Wilson CG, Angeles DM. Differential Effects of the Retinopathy of Prematurity Exam on the Physiology of Premature Infants. J Perinatol. 2019 https://doi.org/10.1038/s41372-01910331-z. (03/2020)
• Kirpalani H1, Ratcliffe SJ2, Keszler M3, Davis PG4, Foglia EE5, Te Pas A6, Fernando M7, Chaudhary A8, Localio R7, van Kaam AH9, Onland W9, Owen LS10,11,12, Schmölzer GM13, Katheria A14, Hummler H15,16, Lista G17, Abbasi S18, Klotz D19, Simma B20, Nadkarni V21, Poulain FR22, Donn SM23, Kim HS24, Park WS25, Cadet C26, Kong JY27, Smith A28, Guillen U29, Liley HG30, Hopper AO31, Tamura M32; SAIL Site Investigators. Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants: The SAIL Randomized Clinical Trial.  JAMA 2019 Mar 26;321 (12): 1165-1175. Doi: 10.1001/jama.2019.1660. (03/2019)
• Kanady J A, Aruni A W, Ninnis J R, Hopper A O, Blood J D, . . . Blood A B. (2012). Nitrate reductase activity of bacteria in saliva of term and preterm infants. Nitric Oxide-Biology and Chemistry, 27(4), 193-200. The salivary glands of adults concentrate nitrate from plasma into saliva where it is converted to nitrite by bacterial nitrate reductases. Nitrite can play a beneficial role in adult gastrointestinal and cardiovascular physiology. When nitrite is swallowed, some of it is converted to nitric oxide (NO) in the stomach and may then exert protective effects in the gastrointestinal tract and throughout the body. It has yet to be determined either when newborn infants acquire oral nitrate reducing bacteria or what the effects of antimicrobial therapy or premature birth may be on the bacterial processing of nitrate to nitrite. We measured nitrate and nitrite levels in the saliva of adults and both preterm and term human infants in the early weeks of life. We also measured oral bacterial reductase activity in the saliva of both infants and adults, and characterized the species of nitrate reducing bacteria present. Oral bacterial conversion of nitrate to nitrite in infants was either undetectable or markedly lower than the conversion rates of adults. No measurable reductase activity was found in infants within the first two weeks of life, despite the presence of oral nitrate reducing bacteria such as Actinomyces odontolyticus, Veillonella atypica, and Rothia mucilaginosa. We conclude that relatively little nitrite reaches the infant gastrointestinal tract due to the lack of oral bacterial nitrate reductase activity. Given the importance of the nitrate-nitrite-NO axis in adults, the lack of oral nitrate-reducing bacteria in infants may be relevant to the vulnerability of newborns to hypoxic stress and gastrointestinal tract pathologies. (C) 2012 Elsevier Inc. All rights reserved. (12/2012) (link)
• Solomon T, Ninnis J, Deming D, Merritt T A, & Hopper A. (2011). Use of propranolol for treatment of hemangiomas in PHACE syndrome. Journal of Perinatology, 31(11), 739-741. We report the case of a 29-week preterm infant with PHACE (posterior fossa malformations, hemangionas, arterial anomalies, cardiac anomalies, eye anomalies) syndrome. PHACE syndrome is a neurocutaneous disorder with large facial segmental hemangionas associated with anomalies of the brain, eye, heart and aorta. The hemangiomas in our patient were problematic, distorting the airway and interfering with respirations to the point of requiring mechanical ventilation. Consultation with several different centers with medical expertize in treatment of congenital hemangiomas revealed different views on the best management strategy. In this infant, the hemangiomas progressed with failure to involute despite currently recommended therapy including corticosteroids and vincristine. Therefore, the infant was treated with propranolol and had significant regression of the hemangiomas. The use of propranolol for the treatment of infantile hemangiomas is reviewed. Journal of Perinatology (2011) 31, 739-741; doi:10.1038/jp.2011.28 (11/2011) (link)
• Ibrahim Y I, Ninnis J R, Hopper A O, Deming D D, Zhang A X, . . . Blood A B. (2011). Inhaled Nitric Oxide Therapy Increases Blood Nitrite, Nitrate, and S-Nitrosohemoglobin Concentrations in Infants with Pulmonary Hypertension. J Pediatr, , . OBJECTIVE: To measure the circulating concentrations of nitric oxide (NO) adducts with NO bioactivity after inhaled NO (iNO) therapy in infants with pulmonary hypertension. STUDY DESIGN: In this single center study, 5 sequential blood samples were collected from infants with pulmonary hypertension before, during, and after therapy with iNO (n = 17). Samples were collected from a control group of hospitalized infants without pulmonary hypertension (n = 16) and from healthy adults for comparison (n = 12). RESULTS: After beginning iNO (20 ppm) whole blood nitrite levels increased approximately two-fold within 2 hours (P<.01). Whole blood nitrate levels increased to 4-fold higher than baseline during treatment with 20 ppm iNO (P<.01). S-nitrosohemoglobin increased measurably after beginning iNO (P<.01), whereas iron nitrosyl hemoglobin and total hemoglobin-bound NO-species compounds did not change. CONCLUSION: Treatment of pulmonary hypertensive infants with iNO results in increases in levels of nitrite, nitrate, and S-nitrosohemoglobin in circulating blood. We speculate that these compounds may be carriers of NO bioactivity throughout the body and account for peripheral effects of iNO in the brain, heart, and other organs. (09/2011) (link)
• Morkos AA, Hopper AO, Deming DD, Yellon SM, Wycliffe N, Ashwal S, Sowers LC, Peverini RL, Angeles DM. "Elevated Total Peripheral Leukocyte Count May Identify Risk for Neurological Disability in Asphyxiated Term Neonates." J Perinatology 27.6 (2007): 365-370. (04/2007)
• Miao G, Ostrowski RP, Mace J, Hough J, Hopper A, Peverini R, Chinnock R, Zhang J, Hathout E. "Dynamic production of hypoxia-inducible factor-1alpha in early tranplanted islets." American Journal Transplant 6.11 (2006): 2636-2643. (11/2006)
• Rabin CW, Hopper AO, Job L, Peverini RL, Clark SJ, Deming DD, Nelson JC, Vyhmeister NR. "Incidence of Low Free T4 values in Premature Infants as Determined by Direct Equilibrium Dialysis." Journal of Perinatology 01. (2004): 640-644. (01/2004)