About Chirag Nepal, PhD

I work with integrative analyses of large-scale genomics data to uncover novel biology regarding our understanding on transcription and epigenetics regulation.

Key publications

Alternative promoters in CpG depleted regions pervasively account for epigenetic misregulation of cancer transcriptomes.

Nepal. C. et al, Nature Communications volume 14, Article number: 2712 (2023)

https://www.nature.com/articles/s41467-023-38272-4

 

 

Integrative molecular characterization of gallbladder cancer presents microenvironment-associated subtypes related to survival.

Nepal. C. et al, Journal of Hepatology, 2020 Dec 1

https://www.sciencedirect.com/science/article/pii/S0168827820338204?via%3Dihub

Editorial: https://www.journal-of-hepatology.eu/article/S0168-8278(21)00007-6/fulltext

 

Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma.

Nepal. C. et al, Hepatology, 2018 Sep

https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.29764

Editorial: https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.29830

Cover article: https://aasldpubs.onlinelibrary.wiley.com/toc/15273350/2018/68/3

 

Ancestrally duplicated conserved noncoding element suggests dual regulatory roles of HOTAIR in cis and trans. Nepal. C. et al, iScience, Volume 23, 2020

https://www.sciencedirect.com/science/article/pii/S2589004220301929

 

Dual-initiation promoters with intertwined canonical and TCT/TOP transcription start sites diversify transcript processing.

Nepal. C. et al, Nature Communications, 2020

https://www.nature.com/articles/s41467-019-13687-0

 

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements. Baranasic D et al, Nature Genetics. 2022

https://www.nature.com/articles/s41588-022-01089-w

 

Two independent transcription initiation codes overlap on vertebrate core promoter.

Haberle V et al Nature, 507, 381-385(2014)

https://www.nature.com/articles/nature12974