Publications

Scholarly Journals--Published

• Mayagoitia K, Shin SD, Rubini M, Siebold L, Wilson CG, Bellinger DL, Figueroa JD, Soriano S. Short-term exposure to dietary cholesterol is associated with downregulation of interleukin-15, reduced thigmotaxis and memory impairment in mice. Behav Brain Res. 2020 Sep 1;393:112779. doi: 10.1016/j.bbr.2020.112779. Epub 2020 Jun 22. PubMed PMID: 32585301 (09/2020)
• Shin SD, Shin A, Mayagoitia K, Siebold L, Rubini M, Wilson CG, Bellinger DL, Soriano S. Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C. J Neuroinflammation. 2019 Dec 17;16(1):269. doi: 10.1186/s12974-019-1663-5. PubMed PMID: 31847862; PubMed Central PMCID: PMC6918596 (12/2019)
• Shin SD, Shin A, Mayagoitia K, Wilson CG, Bellinger DL, Soriano S. Interferon downstream signaling is activated early in pre-symptomatic Niemann-Pick disease type C. Neurosci Lett. 2019 Jul 27;706:43-50. doi: 10.1016/j.neulet.2019.05.005. Epub 2019 May 5. PubMed PMID: 31067492 (07/2019) (link)
• Cupino TL, Watson BA, Cupino AC, Oda K, Ghamsary MG, Soriano S, Kirsch WM. Stability and bioactivity of chitosan as a transfection agent in primary human cell cultures: A case for chitosan-only controls. Carbohydr Polym. 2018 Jan 15;180:376-384. doi: 10.1016/j.carbpol.2017.10.021. Epub 2017 Oct 6. PubMed PMID: 29103517; PubMed Central PMCID: PMC5699233 (01/2018)
• Gongol B, Marin TL, Jeppson JD, Mayagoitia K, Shin S, Sanchez N, Kirsch WM, Vinters HV, Wilson CG, Ghribi O, Soriano S. Cellular hormetic response to 27-hydroxycholesterol promotes neuroprotection through AICD induction of MAST4 abundance and kinase activity. Sci Rep. 2017 Oct 24;7(1):13898. doi: 10.1038/s41598-017-13933-9. PubMed PMID: 29066835; PubMed Central PMCID: PMC5654999 (10/2017)
• Hallaq R, Volpicelli F, Cuchillo-Ibanez I, Hooper C, Mizuno K, Uwanogho D, Causevic M, Asuni A, To A, Soriano S, Giese KP, Lovestone S, Killick R.The Notch intracellular domain represses CRE-dependent transcription. Cell Signal. 2015 Mar;27(3):621-9. doi: 10.1016/j.cellsig.2014.11.034. Epub 2014 Dec 3. PubMed PMID: 25479589 (03/2015)
•   Castello MA, Jeppson JD, Soriano S. Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer's disease. BMC Neurol.2014 Sep 2;14:169. doi: 10.1186/s12883-014-0169-0. PubMed PMID: 25179671; PubMed Central PMCID: PMC4236650 (09/2014)
• Castello MA, Soriano S. On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis. Ageing Res Rev. 2014 Jan;13:10-2. doi: 10.1016/j.arr.2013.10.001. Epub 2013 Nov 16. Review. PubMed PMID: 24252390   (01/2014)
• Castello MA, Soriano S. Rational heterodoxy: cholesterol reformation of the amyloid doctrine. Ageing Res Rev. 2013 Jan;12(1):282-8. doi: 10.1016/j.arr.2012.06.007. Epub 2012 Jul 6. Review. PubMed PMID: 22771381 (01/2013)
• Nunes A, Pressey SN, Cooper JD, Soriano S. Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis. Neurobiol Dis. 2011 Jun;42(3):349-59. doi: 10.1016/j.nbd.2011.01.028. Epub 2011 Feb 17. PubMed PMID: 21303697 (06/2011)
• Engmann O, Hortobágyi T, Thompson AJ, Guadagno J, Troakes C, Soriano S, Al-Sarraj S, Kim Y, Giese KP. Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease. Biol Psychiatry. 2011 Jul 15;70(2):159-68. doi: 10.1016/j.biopsych.2011.04.011. Epub 2011 May 26. PubMed PMID: 21616478 (05/2011)
• Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, Soriano S. Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons. J Mol Neurosci. 2011 Mar;43(3):326-32. doi: 10.1007/s12031-010-9444-8. Epub 2010 Sep 14. PubMed PMID: 20838929 (03/2011)
• Canuet L, Ishii R, Iwase M, Ikezawa K, Kurimoto R, Takahashi H, Currais A, Azechi M, Aoki Y, Nakahachi T, Soriano S, Takeda M. Psychopathology and working memory-induced activation of the prefrontal cortex in schizophrenia-like psychosis of epilepsy: Evidence from magnetoencephalography. Psychiatry Clin Neurosci. 2011 Mar;65(2):183-90. doi: 10.1111/j.1440-1819.2010.02179.x. PubMed PMID: 21414092 (03/2011)
• Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. Dement Geriatr Cogn Disord. 2010;30(4):302-8. doi: 10.1159/000320482. Epub 2010 Sep 25. PubMed PMID: 20881395 (09/2010)
• Currais A, Hortobágyi T, Soriano S. The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease. Aging (Albany NY). 2009 Apr 28;1(4):363-71. doi: 10.18632/aging.100045. Review. PubMed PMID: 20157524; PubMed Central PMCID: PMC2806021 (01/2010)
• Skerget K, Taler-Vercic A, Bavdek A, Hodnik V, Ceru S, Tusek-Znidaric M, Kumm T, Pitsi D, Pompe-Novak M, Palumaa P, Soriano S, Kopitar-Jerala N, Turk V, Anderluh G, Zerovnik E. Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells. J Biol Chem. 2010 Jan 29;285(5):3201-10. doi: 10.1074/jbc.M109.024620. Epub 2009 Dec 2. PubMed PMID: 19955183; PubMed Central PMCID: PMC2823404 (01/2010)
• Nunes A, Ohadi M, Rahimi A, Aghajani A, Najmabadi H, Currais A, Soriano S. A mutation in the calreticulin gene promoter in a family case of schizoaffective disorder leads to its aberrant transcriptional activation. Brain Res. 2008 Nov 6;1239:36-41. doi: 10.1016/j.brainres.2008.08.064. Epub 2008 Sep 4. PubMed PMID: 18801343 (11/2008)
• Malik B, Currais A, Soriano S. Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease. J Neurochem. 2008 Jul;106(2):912-6. doi: 10.1111/j.1471-4159.2008.05446.x. Epub 2008 May 2. PubMed PMID: 18466334 (07/2008)
• Malik B, Currais A, Andres A, Towlson C, Pitsi D, Nunes A, Niblock M, Cooper J, Hortobágyi T, Soriano S. Loss of neuronal cell cycle control as a mechanism of neurodegeneration in the presenilin-1 Alzheimer's disease brain. Cell Cycle. 2008 Mar 1;7(5):637-46. doi: 10.4161/cc.7.5.5427. Epub 2007 Dec 6. PubMed PMID: 18239458 (03/2008)
• Chevallier NL, Soriano S, Kang DE, Masliah E, Hu G, Koo EH. Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. Am J Pathol. 2005 Jul;167(1):151-9. doi: 10.1016/S0002-9440(10)62962-8. PubMed PMID: 15972961; PubMed Central PMCID: PMC1603433 (07/2005)
• Lu DC, Soriano S, Bredesen DE, Koo EH. Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem. 2003 Nov;87(3):733-41. doi: 10.1046/j.1471-4159.2003.02059.x. PubMed PMID: 14535955 (11/2003)
• Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell. 2002 Sep 20;110(6):751-62. doi: 10.1016/s0092-8674(02)00970-4. PubMed PMID: 12297048 (09/2002)
• Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8760-5. doi: 10.1073/pnas.132045399. Epub 2002 Jun 17. PubMed PMID: 12070348; PubMed Central PMCID: PMC124372 (06/2002)
• Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH, Wu X, Zheng H. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10863-8. doi: 10.1073/pnas.191284198. Epub 2001 Aug 21. PubMed PMID: 11517342; PubMed Central PMCID: PMC58565 (09/2001)
• Soriano S, Lu DC, Chandra S, Pietrzik CU, Koo EH. The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases. J Biol Chem. 2001 Aug 3;276(31):29045-50. doi: 10.1074/jbc.M102456200. Epub 2001 Jun 7. PubMed PMID: 11397796 (08/2001)
• Soriano S, Kang DE, Fu M, Pestell R, Chevallier N, Zheng H, Koo EH. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J Cell Biol. 2001 Feb 19;152(4):785-94. doi: 10.1083/jcb.152.4.785. PubMed PMID: 11266469; PubMed Central PMCID: PMC2195782 (02/2001)
• Saura CA, Tomita T, Soriano S, Takahashi M, Leem JY, Honda T, Koo EH, Iwatsubo T, Thinakaran G. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. J Biol Chem. 2000 Jun 2;275(22):17136-42. doi: 10.1074/jbc.M909624199. PubMed PMID: 10748144 (06/2000)
• Soriano S, Chyung AS, Chen X, Stokin GB, Lee VM, Koo EH. Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments. J Biol Chem. 1999 Nov 5;274(45):32295-300. doi: 10.1074/jbc.274.45.32295. PubMed PMID: 10542269 (11/1999)
• Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem. 1999 Jul 2;274(27):18851-6. doi: 10.1074/jbc.274.27.18851. PubMed PMID: 10383380 (07/1999)
• Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway. J Neurosci. 1999 Jun 1;19(11):4229-37. PubMed PMID: 10341227; PubMed Central PMCID: PMC6782616 (06/1999)
• Sanchez-Perez AM, Soriano S, Clarke AR, Gaston K. Disruption of the human papillomavirus type 16 E2 gene protects cervical carcinoma cells from E2F-induced apoptosis. J Gen Virol. 1997 Nov;78 ( Pt 11):3009-18. doi: 10.1099/0022-1317-78-11-3009. PubMed PMID: 9367388 (11/1997)
• Soriano S, Thomas S, High S, Griffiths G, D'santos C, Cullen P, Banting G. Membrane association, localization and topology of rat inositol 1,4,5-trisphosphate 3-kinase B: implications for membrane traffic and Ca2+ homoeostasis. Biochem J. 1997 Jun 1;324 ( Pt 2):579-89. doi: 10.1042/bj3240579. PubMed PMID: 9182721; PubMed Central PMCID: PMC1218469 (06/1997)
• Soriano S, Banting G. Possible roles of inositol 1,4,5-trisphosphate 3-kinase B in calcium homeostasis. FEBS Lett. 1997 Feb 10;403(1):1-4. doi: 10.1016/s0014-5793(96)01516-5. PubMed PMID: 9038348 (02/1997)
• Thomas S, Soriano S, d'Santos C, Banting G. Expression of recombinant rat myo-inositol 1,4,5-trisphosphate 3-kinase B suggests a regulatory role for its N-terminus. Biochem J. 1996 Nov 1;319 ( Pt 3):713-6. doi: 10.1042/bj3190713. PubMed PMID: 8920971; PubMed Central PMCID: PMC1217847 (11/1996)

Books and Chapters

• Currais A, Hortobagyi T, Soriano S. The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease. In: Cell Cycle Regulators in Alzheimer's Disease. Padmanabhan J, editor. Kerala, India: Transworld Research Network; 2010. p.39-53 (01/2010)
• Kang D, Soriano S, Xia X, Zheng H, Koo E. Presenilin 1 functions as a scaffold to link sequential phosphorylation of β-catenin independent of γ-secretase activity . In: Alzheimer’s Disease and Related Disorders: Research Advances. Iqbal K, Winblad B, editors. Bucharest: Ana Aslam International Academy of Aging; 2003. Chapter 34; p.385-94 (01/2003)
• Koo E, Soriano S, Kang D. Notch from neurodevelopment to neurodegeneration: keeping the fate. Berlin Heidelberg: Springer; 2002. 119-129 (01/2002)
• Soriano S, Kang D, Chevallier N, Koo E. Functional consequences of the interaction of presenilin 1 with β-catenin . In: Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics. Iqbal K, Sisodia S, Winblad B, editors. London, UK: John Wiley & Sons; 2001. Chapter 50; p.541-8 (01/2001)