Publications

Scholarly Journals--Published

• Ding, L., Zhang, E., Yang, Q., Jin, L., Sousa, K.M., Dong, B., Wang, Y., Tu, J., Ma, X., Tian, J., Zhang, H., Fang., Z., Guan, A., Zhang, Y., Wang, Z., Moore, D.M., Yang, L., and Huang, W. 2021. Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice. Proceedings of the National Academy of Sciences. 118(6) 1-10. PMID: 33526687 (02/2021)
• Schoelles-Williams, J., English, D.E., Godwin, D.A., Hammond, L., Mason, H.L., Petrelli, H.M.W., Roni, M., Sousa, K., Van Amburgh, J.A., and Ross, L.J., 2019. Report of the 2018-2019 Student Affairs Standing Committee. American Journal of Pharmaceutical Education. PMID: 32001894  (2019)
• Fulford, M.J., Early, J.L., Godwin, D.A., Gonyeau, M., Griffin, S.E., Rattinger, G.B., Shields, K.M., Sousa, K., and Nemire, R.E. 2018. Report of the 2017-2018 Academic Affairs Standing Committee. American Journal of Pharmaceutical Education. 82 (7): 899-907. PMID: 30323404 (2018)
• Chestnut, R.J., Atcha, I.I., Do, D.P., Harrell, K., Holland, A., Miller, M.L., Shields, K.M., Sousa, K., Van Den Broek R.A., Zeeman, J.M., Nohria, R., and Adams, J.L. 2017. Report of the 2016-2017 Student Affairs Standing Committee. American Journal of Pharmaceutical Education. 81(8): 1-13. PMID: 29200460 (2017)
• Li, S., Vinci, A., Behensen, J., Jellbauer, S., Raffatellu, M., Sousa, K.M., Edwards, R., Nguyen, N.T., Stamos, M.J., and Pigazzi, A. 2017. Bariatric surgery attenuates DSS-induced colitis in an obese murine model. Surg. Obes. Relat. Dis. 13(4): 661-668. PMID: 28185763 (2017)
• Ding, L., Sousa, K.M., Jin, L., Kim, B.W., Ramirez, R., Dong, B, Xiao, Z., Gu, Y., Yang, Q., Wang, J., Yu, D., Shones, D., Yang, L., Moore, D., Wang, Z., and Huang, W.  2016. Vertical sleeve gastrectomy activates GPBAR1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice. Hepatology, 64(3):760-73. PMID: 27312543 (2016)
• Yu, D*., Sousa, K.M.*, Mattern, D.L., Wagner, J., Vaidehi, N., and Huang, W.* 2015. Stereoselective synthesis and biological evalutation of alkyl-subsituted bile acids derivatives as novel agonists for the G protein-coupled receptor TGR5. Bioorganic and Medicinal Chemistry. 23(7). 1613-28. PMID: 25735208 *corresponding authors (2015)
• Theofilopoulos, S., Wang, Y., Kitambi, S., Sacchetti, P., Sousa, K.M., Bodin, K., Kirk, J., Gustafsson, M., Karu, K., Ernfors, P., Sjovall, J., Griffiths, W.J., and Arenas, E. 2013. Brain endogenous Liver X Receptor ligands selectively promote midbrain dopamine neurogenesis. Nature Chemical Biology. 9(2)126-33. PMID: 23292650 (2013)
• Sousa, K.M., Villaescusa, J.C., Cajanek, L., Ondr, J.K., Castelo-Branco, G., Hofstra, W., Brya, V., Bergman, T., Lang, R.A., and Arenas, E. 2010. Wnt2 regulates progenitor proliferation in the developing ventral midbrain. Journal of Biological Chemistry. 285(10) 7246-53. PMID: 20018874, PMCID: 2844173 (2010)
• Kawai, M., Sousa, K.M., MacDougald, O.A., and Rosen, C.J. 2010. The many faces of PPARg: novel insights for the skeleton. Am. J. Physiol. Endocrinol. Met. 299(1): E3-9. PMID: 20407009, PMCID: 2904052 (2010)
• Gerin, I, Bommer, G.T., McCoin, C.S., Sousa, K.M., and MacDougald, O.A. 2010. Role for miRNA-378*/378 in adipocyte gene expression and lipogenesis. Am. J. Physiol. Endocrinol. Met. 299(2):E198-206. PMID: 20484008, PMCID: 2928515 (2010)
• Clark, A.M., Sousa K.M., Chisolm, C.N., MacDougald, O.A., and Kennedy, R.T. 2010. Reversibly-sealed multilayer microfluidic device for integrated cell perfusion and on-line chemical analysis of cultured adipocyte secretions. Analytical and Bioanalytical Chemistry. 397(7):2939-47. PMID: 20549489 (2010)
• Wang, Y., *Sousa, K.S., Bodin, K., Theofilopoulos, S., Sacchetti, P., Hornshaw., M., Woffendin,G., Karu, K., Sjovall, J., Arenas, E., Griffiths, W.J. 2009. Targeted analysis of oxysterols in the embryonic central nervous system. Molecular Biosystems. 5(5):529-41. PMID: 19381367, PMCID: 2702751 *co-first author (10/2009)
• Clark, A.M., Sousa, K.M., Jennings, C., MacDougald O.A., and Kennedy, R.T., 2009. Continuous-flow enzyme assay on a microfluidic chip for monitoring of glycerol secretion from cultured adipocytes. Analytical Chemistry. 81(6):2350-6. PMID: 19231843, PMCID: 2659456 (2009)
• Castelo-Branco, G., Minina, E., Andersson, E.R., Sousa, K.M., Ribeiro, D.,  Prakash, N., Kokubu, C., Imai, K., Wurst, W., and Arenas E. 2009. Delayed dopaminergic differentiation in Lrp6 mutant mice. Developmental Dynamics. 239(1) 211-21. PMID: 19795519 (2009)
• Sacchetti, P., *Sousa, K.M., Hall, A.C., Liste, I., Steffensen, K., Hazenberg, C., Theofilopoulos, S., Ahrlund-Richter, L., Hovatta, O., Gustaffson, J-A., and Arenas E. 2009. Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell. 5(4) 409-19. PMID: 19796621 *co-first author (2009)
• Sousa, K.M., Mira, H., Hall, A.H., Jansson-Sjöstrand, L., and Arenas, E 2007. Microarray analyses support a role for Nurr1 in promoting neuronal differentiation and resistance to oxidative stress. Stem Cells. 25(2):511-9. PMID: 17038671 (2007)
• Bennett, C.N., Ouyang, H., Ma, Y.L., Zeng, Q., Gerin, I., Sousa, K.M., Lane, T.F.,Krishnan, V., Hankenson, K.D., and MacDougald, O.A., 2007. Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. Journal of Bone and Mineral Research. 22(12):1924-32. PMID: 17708715 (2007)
• Castelo-Branco, G., Sousa K.M., Bryja, V., Pinto, L., Wagner, J., and Arenas, E. 2006. Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. Molecular and Cellular Neuroscience. 31: 251-62. PMID: 16243537 (2006)
• Berghuis, P., Dobszay, M.B., Wang, X., Spano, S., Ledda, F., Sousa, K.M., Schulte, G., Ernfors, P., Mackie, K., Paratcha, G., Hurd, Y., and Harkany T. 2006. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proceedings of the National Academy of Sciences. 22: 19115-20. PMID: 16357196 (2006)
• Rawal, N., Castelo-Branco, G., Sousa, K.M., Kele, J., Kobayashi, K., Okano, H., and Arenas, E. 2006. Spatial and temporal expression dynamics of Wnt signaling components in the developing midbrain. Experimental Cell Research. 312: 1626-36. PMID: 16510140 (2006)
• Shemer, I., Holmgren, C., Min, R., Fulöp, F., Zilberter, M., Sousa, K.M., Farkas, T., Hartig, W., Penke, B., Burnashev, N., Tanila, H., Zilberter, Y., and Harkany, T. 2006. Non-fibrillar b-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors. European Journal of Neuroscience. 23: 2035-47. PMID: 16630051 (2006)
• Schulte, G., Bryja, V., Rawal N., Castelo-Branco, G., Sousa, K.M., and Arenas E. 2005. Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. Journal of Neurochemistry. 92: 1550-3. PMID: 15748172 (2005)
• Shariatmadari, M., Peyronnet, J., Papachristou, P., Horn, Z., Sousa, K.M., Arenas, E., and Ringstedt, T. 2005. Elevated Wnt levels in the neural tube impairs the function of adherens junctions during neurulation. Molecular and Cellular Neuroscience. 30: 437-51. PMID: 16243537 (2005)
• Harkany, T., Holmgren, C., Härtig W, Qureshi, T., Chaudhry F.A., Storm-Mathisen, J., Dobszay, M.B., Berghuis, P., Schulte, G., Sousa, K.M., Fremeau Jr., R.T., Edwards, R.H., Mackie, K., Ernfors, P., and Zilberter Y. 2004. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. Journal of Neuroscience. 24: 4978-4988. PMID: 15163690 (2004)
• Berghuis, P., Dobszay, M.B., Sousa, K.M., Schulte, G., Mager, P.P., Hartig, W., Görcs, T.J., Zilberter, Y., Ernfors, P., and Harkany, T. 2004. Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively fast-spiking interneurons. European Journal of Neuroscience. 20: 1290-306. PMID: 15341601 (2004)
• Castelo-Branco, G., Wagner, J., Rodriguez, F.J., Kele, J., Sousa, K., Rawal, N., Amalia Pasolli, H., Fuchs, E., Kitajewski, J., and Arenas, E. 2003. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a and Wnt-5a. Proceedings of the National Academy of Sciences. 22: 12747–12752. PMID: 14557550 PMCID: 240689 (2003)
• Akerud, P., Holm, P.C., Castelo-Branco, G., Sousa, K., Rodriguez, F.J., and Arenas, E. 2002. Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson’s disease. Molecular and Cellular Neurosciences. 21:205-222. PMID: 12401443 (2002)
• Brown, C.E., Howe, L.H., Sousa, K., Alley, S.C., Tan, S., and Workman, J.L. 2001. The ATM-related factor Tra1p is an essential direct target of transcription activators in the SAGA and Nua4 complexes. Science. 292: 2333-2337. PMID: 1142366 (2001)