Publications

Scholarly Journals--Published

  • Deng S, Jin P, Sherchan P, Liu S, Cui Y, Huang L, Zhang JH, Gong Y, and Tang J. Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice. Journal of Neuroinflammation, 2021 Mar 1;18(1):62. (03/2021)
  • Yu S, Doycheva D, Gamdzyk M, Yang Y, Lenahan C, Li G, Li D, Lian L, Tang J, Lu J, Zhang JH. Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats. Journal of Neuroinflammation, 2021 Jan 19;18(1):26. (01/2021)
  • Gao L, Shi H, Sherchan P, Tang H, Li P, Xie S, Liu R, Hu X, Tang J, Xia Y, Zhang JH. Inhibition of Lysophosphatidic Acid Receptor 1 Attenuates Neuroinflammation via PGE2/EP2/NOX2 Signalling and Improves the Outcome of Intracerebral Haemorrhage in Mice. Brain Behavior and Immunity, 2021 Jan;91:615-626. (01/2021)
  • Fang Y, Ren R, Shi H, Huang L, Lenahan C, Lu Q, Tang L, Huang Y, Tang J, Zhang J, Zhang JH. Pituitary Adenylate Cyclase-Activating Polypeptide: A Promising Neuroprotective Peptide in Stroke. Aging and Diseases. 2020 Dec 1;11(6):1496-1512. (12/2020)
  • Gamdzyk M, Doycheva D, Kang R, Tang H, Travis Z, Tang J, Zhang JH. GW0742 Activates miR-17-5p and Inhibits TXNIP/NLRP3-mediated Inflammation After Hypoxic-Ischemic Injury in rats and in PC12 cells. Journal of Cellular and Molecular Medicine. 2020 Nov;24(21):12318-12330. (11/2020)
  • Gamdzyk M, Lenahan, Tang J, Zhang JH. Role of peroxisome proliferator-activated receptors in stroke prevention and therapy—The best is yet to come? Journal of Neuroscience Research. 2020 Nov;98(11):2275-2289. (11/2020)
  • Luo Y, Fang Y, Kang R, Lenahan C, Gamzyk M, Zhang Z, Okada T, Tang J, Chen S, and Zhang JH. Inhibition of EZH2 attenuates neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB in a rat model of subarachnoid hemorrhage. Stroke, 2020 Nov;51(11):3320-3331. (11/2020)
  • Fang Y, Shi H, Ren R, Huang L, Okada T, Lenahan C, Gamdzyk M, Travis Z, Lu Q, Tang L, Huang Y, Zhou K, Tang J, Zhang J, Zhang JH. Pituitary Adenylate Cyclase-Activating Polypeptide Attenuates Brain Edema by Protecting Blood-Brain Barrier and Glymphatic System After Subarachnoid Hemorrhage in Rats. Neurotherapeutics. 2020 Oct;17(4):1954-1972 (10/2020)
  • Deng S, Sherchan P, Jin P, Huang L, Travis Z, Zhang JH, Gong Y, and Tang J. Recombinant CCL17 enhances hematoma resolution and activation of CCR4/ERK/Nrf2/CD163 signaling pathway after intracerebral hemorrhage in mice Neurotherapeutics. 2020 Oct;17(4):1940-1953. (10/2020)
  • Deng S, Sherchan P, Jin P, Huang L, Travis Z, Zhang JH, Gong Y, and Tang J. Recombinant CCL17 enhances hematoma resolution and activation of CCR4/ERK/Nrf2/CD163 signaling pathway after intracerebral hemorrhage in mice Neurotherapeutics. 2020 Oct;17(4):1940-1953. (10/2020)
  • Hu X, Li S, Doycheva DM, Huang L, Lenahan C, Liu R, Huang J, Gao L, Tang J, Zuo G, Zhang JH. Rh-CSF1 attenuates oxidative stress and neuronal apoptosis via CSF1R/PLCG2/PKA/UCP2 signaling pathway in a rat model of neonatal HIE.  Oxidative Medicine and Cellular Longevity. 2020 Oct 7;2020:6801587. (10/2020)
  • Huang L, Tang H, Sherchan P, Lenahan C, Boling W, Tang J, and Zhang JH. The Activation of Phosphatidylserine/CD36/TGF-β1 Pathway prior to Surgical Brain Injury Attenuates Neuroinflammation in Rats. Oxidative Medicine and Cellular Longevity 2020 Aug 11;2020:4921562. (08/2020)
  • Li P, Zhao G, Chen F, Ding Y, Wang T, Liu S, Lu W, Xu W, Flores F, Ocak U, Zhang T, Zhang JH, Tang J. Rh-relaxin-2 Attenuates Degranulation of Mast Cells by Inhibiting NF-κB through PI3K-AKT/TNFAIP3 Pathway in an Experimental Germinal Matrix Hemorrhage Rat Model. Journal of Neuroinflammation, 2020 Aug 28;17(1):250. (08/2020)
  • Wan W, Ding Y, Xie Z, Li Q, Yan F, Enkhjargal B, Pearce WJ, Hartman R, Obenaus A, Zhang JH, Jiang Y, Tang J.  PDGFR-β Modulates Vascular Smooth Muscle Cell Phenotype via IRF-9/SIRT-1/NF-κB Pathway in Subarachnoid Hemorrhage Rats. J Cereb Blood Flow Metab, 2019 Jul;39(7):1369-1380. (07/2019)
  • Ma Q, Manaenko A, Khatibi N, Chen W, Zhang JH, Tang J. Vascular adhesion protein-1 inhibition provides neuroprotection from intracerebral hemorrhage induced brain injury in mice. Journal of Cerebral Blood Flow & Metabolism, 31:881-893, 2011 (2011)
  • Manaenko A, Fathali N, Khatibi N, Lekic T, Hasegawa Y, Tang J, Zhang JH. Arginine- Vasopressin V1a Receptor Inhibition Improves Neurologic Outcomes Following An Intracerebral Hemorrhagic Brain Injury. Neurochemistry International. 58:542-548, 2011 (2011)
  • Wu B, Ma Q, Suzuki H, Chen C, Liu W, Tang J, Zhang J. Recombinant Osteopontin Attenuates Brain Injury after Intracerebral Hemorrhage in Mice. Neurocritical Care, 14:109-117, 2011 (2011)
  • Lekic T, Rolland W, Hartman R, Kamper J, Suzuki H, Tang J, Zhang JH. Characterization of the Brain Injury, Neurobehavioral Profiles and Histopathology in a Rat Model of Cerebellar Hemorrhage. Experimental Neurology, 227:96-103, 2011 (2011)
  • Hu Q, Ma Q, Zhan Y, He Z, Zhou C, Tang J, Zhang JH. Isoflurane Enhanced Hemorrhagic Transformation by Impairing Antioxidant Enzymes in Hyperglycemic MCAO Rats. Stroke, 42:1750-1756, 2011 (2011)
  • Manaenko A, Chen H, Kammer J, Zhang JH, Tang J. Comparison Evans Blue Injection Routes: Intravenous vs. Intraperitoneal, for Measurement of Blood-Brain Barrier in a Mouse Hemorrhage Model. Journal of Neuroscience Methods. 195:206-210, 2011 (2011)
  • Duris K, Manaenko A, Suzuki H, Rolland W, Tang J, Zhang JH. Sampling of CSF via the Cisterna Magna and Blood Collection via the Heart Affects Brain Water Content in a Rat SAH Model. Translational Stroke Research. 2:232-237, 2011 (2011)
  • Chen W, Ma Q, Suzuki H, Hartman R, Tang J, Zhang JH, Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model, Stroke, 42:764-769, 2011 (2011)
  • Khatibi N, Ma Q, Rolland W, Ostrowski R, Fathali N, Martin R, Applegate R, Stier G, Tang J, Zhang J. Isoflurane post-treatment reduces brain injury following intracerebal hemorrhagic stroke in mice. Anesthesia & Analgesia. 2011 May 19. PMID: 21506881 (2011)
  • Eckermann J, Chen W; Jadhav V, Frank H; Colohan A, Tang J, Zhang J. Hydrogen is Neuroprotective against Surgically Induced Brain Injury. Medical Gas Research. 1:7, 2011 (2011)
  • Chen D, Tang J, Khatibi NH, Zhu M, Li Y, Wang C, Jiang R, Tu L, Wang S. Treatment with z-ligustilide, a component of angelica sinensis, reduces brain injury following a subarachnoid hemorrhage in rats. The Journal of pharmacology and experimental therapeutics. 337:663-672, 2011 (2011)
  • Chen C, Manaenko A, Zhan Y, Liu W, Ostrowski RP, Tang J, and Zhang JH. Hydrogen Gas Reduced Acute Hyperglycemia‐Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model. Neuroscience, 169:402-414, 2010 (2010)
  • Wu B, Ma Q, Khatibi N, Chen W, Sozen T, Cheng O, Tang J. Ac-YVAD-CMK Decreases Blood Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin 1β in Intracerebral Hemorrhage Mouse Model. Translational Stroke Research, 1:57-64, 2010 (2010)
  • Tong W, Chen W, Ostrowski RP, Ma Q, Souvenir R, Zhang L, Zhang JH, Tang J. Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats. Developmental Neurobiology, 70:182-194, 2010 (2010)
  • Chen C, Ostrowski RP, Zhou C, Tang J, and Zhang JH. Suppression of Hypoxia-Inducible Factor-1a and Its Downstream Genes Reduces Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Rat Model of Cerebral Ischemia. Journal of Neuroscience Research, 88:2046-2055, 2010 (2010)
  • Manaenko A, Fathali N, Chen H, Suzuki H, Williams S, Zhang JH, Tang J. Heat Shock Protein 70 Upregulation by Geldanamycin Reduces Brain Injury in a Mouse Model of Intracerebral Hemorrhage.  Neurochemistry International, 57:844-850, 2010 (2010)
  • Fathali N, Lekic T, Zhang JH, Tang J. Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats. Intensive Care Medicine, 36:1602-1608, 2010 (2010)
  • Lekic T, Hartman R, Rojas H, Manaenko A, Chen W, Ayer R, Tang J, Zhang JH. Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats. Journal of Neurotrauma. 27:627-37, 2010 (2010)
  • Li Y, Tang J, Khatibi N, Zhu M, Chen D, Zheng W and Wang S. Ginsenoside RB1 Reduces Neurologic Damage is Anti-Apoptotic, and Down-Regulates p53 and BAX in Subarachnoid Hemorrhage.  Current Neurovascular Research, 7:85-94, 2010 (2010)
  • Fathali N, Ostrowski RP, Lekic T, Jadhav V, Tong W, Tang J, Zhang JH. Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury, Critical Care Medicine, 38:572-578, 2010 (2010)
  • Zhou Y, Fathali N, Lekic T, Tang J, Zhang JH. Glibenclamide improves neurological function in neonatal hypoxia-ischemia in rats. Brain Research. 1270:131-139, 2009 (2009)
  • Hartman R, Lekic T, Rojas H, Tang J, and Zhang JH. Assessing functional outcomes following intracerebral hemorrhage in rats. Brain Research, 1280:148-157, 2009 (2009)
  • Chen W, Hartman R, Ayer R, Marcantonio S, Kamper J, Tang J,  Zhang JH. Matrix Metalloproteinases inhibition provides Neuroprotection against Hypoxia-ischemia in the Developing Brain. J Neurochem 111(3): 726-736, 2009   (2009)
  • Manaenko A, Lekic T, Sozen T, Tsuchiyama R, Zhang JH, Tang J. Effect of Gap Junction Inhibition on Intracerebral Hemorrhage-Induced Brain Injury in Mice. Journal of Neurological Research, 31:173-178, 2009 (2009)
  • Tsuchiyama R, Sozen T, Manaenko A, Zhang JH, Tang J. The Effects of Nicotinamide Adenine Dinucleotide on Intracerebral Hemorrhage-Induced Brain Injury in mice. Journal of Neurological Research, 31:179-182, 2009 (2009)
  • Chen W, Jadhav V, Tang J, Zhang JH. HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. Neurobiology of Disease. 31:433-41, 2008 (2008)
  • Chen W, Jadhav V, Tang J, Zhang J. HIF-1α Inhibition Ameliorates Neonatal Brain Damage after Hypoxic-ischemic Injury. Acta Neurochirurgica Supplemet. 102:395-399, 2008 (2008)
  • Lee S, Jadhav V, Ayer RE, Rojas H, Hyong A, Lekic T, Tang J, Zhang JH. Dual effects of melatonin on oxidative stress after surgical brain injury in rats. J Pineal Res. 46:43-8, 2008 (2008)
  • Titova E, Ostrowski R, Kevil C, Tong W, Rojas H, Sowers L, Zhang JH, Tang J. Reduced brain injury in CD18 deficient mice after experimental intracerebral hemorrhage. Journal of Neuroscience Research, 86:3240-3245, 2008 (2008)
  • Hyong A, Jadhav V, Lee S, Tong W, Rowe J, Zhang JH, Tang J. Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. Brain Res. 1215:218-224, 2008 (2008)
  • Bravo TP, Matchett GA, Jadhav V, Martin RD, Jourdain A, Zhang JH, Tang J. Role of Histamine in Brain Protection in Surgical Brain Injury in Mice. Brain Res. 1205:100-107, 2008 (2008)
  • Ostrowski R, Graupner G, Titova E, Zhang J, Chiu J, Dach N, Corleone D, Tang J, Zhang JH. The hyperbaric oxygen preconditioning-induced brain protection is mediated by a reduction of early apoptosis after transient global cerebral ischemia. Neurobiology of Disease. 29:1-13, 2008 (2008)
  • Yata K, Matchett G, Tsubokawa T, Tang J, Kanamaru K, Zhang JH. Granulocyte-coloney stimulating factor inhibits apoptotic neuron loss after neonatal hypoxia-ischemia in rats. Brain Res, 1145:227-238, 2007 (2007)
  • Lo W, Bravo T, Jadhav V, Zhang JH, Tang J. NADPH Oxidase Inhibition Improves Neurological Outcomes in Surgically-Induced Brain Injury. Neuroscience letters, 414/3:228-232, 2007 (2007)
  • Titova E, Ostrowski R, Sowers L, Zhang JH, and Tang J. Effects of Apocynin and Ethanol on Intracerebral Haemorrhage-Induced Brain Injury in Rats. CEPP, 34:845-850, 2007 (2007)
  • Liu S, Tang J, Ostrowski R, Titova E, Monroe C, Chen W, Lo W, Martin R, and Zhang JH. Oxidative Stress after Subarachnoid Hemorrhage in gp91phox Knockout Mice. Can J Neurol Sci. 34:356-361, 2007 (2007)
  • Ostrowski R, Tang J, Zhang HJ. Hyperbaric oxygen suppresses NADPH oxidase in a rat subarachnoid hemorrhage model. Stroke, 37:1314-1318, 2006 (2006 - 2007)
  • Tang J, Kusaka I, Massey RA, Rollins S, Zhang JH. Increased RhoA Translocation in Aorta of Diabetic Rats. Acta Pharmacologia Sinica, 27:543-548, 2006 (2006)
  • Tang J, Fitzgerald SM, Boughtman BN, Cole SW, Brands MW, Zhang JH. Decreased RhoA Expression in Myocardium of Diabetic Rats. Canadian Journal of Physiology and Pharmacology, 83:775-783, 2005 (2005)
  • Dai Y, Tang J, Zhang JH. Role of Cl- in Cerebral Vascular Tone and Expression of Na+-K+-2Cl- Co-transporter after Neonatal Hypoxia- Ischemia. Canadian Journal of Physiology and Pharmacology, 83:767-773, 2005 (2005)
  • Tang J, Liu J, Zhou C, Ostanin D, Grisham M, Granger DN, Nanda A, Zhang JH. Role of NADPH Oxidase in the Brain Injury of Intracerebral Hemorrhage. J Neurochem.  94:1342-1350, 2005 (2005)
  • Smelley C, Specian RD, Tang J, Zhang JH. Acute gastric changes after intracerebral hemorrhage in rats. Brain Res. 1038:198-207, 2005 (2005)
  • Park S, Yamaguchi M, Zhou C, Calvert JW, Tang J, Zhang JH. Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke  35(10):2412-2417, 2004 (2004)
  • Park S, Zhou C, Tang J, Colohan A, J.H. Zhang JH. Apoptosis and Subarachnoid Hemorrhage. Pharmacology of Cerebral Ischemia. Ed. J. Krieglstein, S. Klumpp. p217-227, 2004 (2004)
  • Kusaka I, Kusaka G, Zhou C, Ishikawa M, Nanda A, Granger DN, Zhang JH &  Tang J. Role of AT1 Receptors and NAD(P)H Oxidase in Diabetes-Aggravated Ischemic Brain Injury. Am J Physiol Heart Circ Physiol 286(6):H2442-51, 2004 (2004)
  • Tang J, Liu J, Zhou C, Alexander S, Nanda A, Granger DN, Zhang JH. Deficiency of Metalloproteinase-9 Gene Enhances Brain Injury caused by Collagenase-Induced Intracerebral Hemorrhage. J Cereb Blood Flow Metab. 24:1133-1145, 2004 (2004)
  • Massey AR, Miao L, Smith BN, Liu J, Kusaka I, Zhang J, Tang J. Increased RhoA translocation in renal cortex of diabetic rats. Life Sciences 9350:1-10, 2003 (2003)
  • Yin W, Tibbs R, Tang J, Badr A & Zhang J. Haemoglobin and ATP levels in CSF from a dog model of vasospasm. J Clin Neurosci 9:425-428, 2002 (2002)
  • Miao L, Calvert J, Tang J & Zhang J. Rho-A and Rho-kinase in Cerebral Arteries in Diabetic Rats. Life Sci 71: 1175-1185, 2002 (2002)
  • Satoh M, Perkins E, Kimura H, Tang J, Chun Y, Heistad DD, Zhang JH. Posttreatment with adenovirus-mediated gene transfer of calcitonin gene-related peptide to reverse cerebral vasospasm in dogs. J Neurosurg 97:136-42, 2002 (2002)
  • Akin E, Clower B, Tibbs R, Tang J, Zhang J. Bilirubin produces apoptosis in cultured bovine brain endothelial cells. Brain Res 931:168-175, 2002 (2002)
  • Miao L, Calvert J, Tang J, Parent A & Zhang J. Age‑related Rho‑A expression in Blood Vessels of Rats. Mechanism of Aging and Development 122: 1757-1770, 2001 (2001 - 2002)
  • Miao L, Tang J, Esposito D & Zhang J. Age‑related Changes of P2 Receptor mRNA of Rat Cerebral Arteries. Exp Gerontol 37: 67-79, 2001 (2001)
  • Tang J, Neidigh J, Cooksey R & McClain D. Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance. Diabetes 49: 1492-6, 2000 (2000)
  • Tang J & Zhang J. Mechanisms of [Ca2+] elevation by H2O2 in islets of rats. Life Sciences 68:475-481, 2000 (2000)
  • Veerababu G, Tang J, Hoffman R, Daniels M, Hebert L, Crook E, Cooksey R & McClain D. Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance. Diabetes 49: 2070-2078, 2000.   (2000)
  • She HY, Rockow S, Tang J, Nishimura R, Skolnik EY, Chen M, Margolis B & Li W. Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptors in living cells. Mol Biol Cell 8: 1709-1721, 1997 (1997)
  • Tang J, Feng G & Li W. Induced direct binding of adapter protein NCK to the GTPase-activating protein (GAP)-associated protein p62 by epidermal growth factor. Oncogene 15: 1823-1832, 1997 (1997)
  • Roe MW, Worley JF, Tokuyama Y, Philipson LH, Sturis J, Tang J, Dukes ID, Bell GI & Polonsky KS. Non-insulin-dependent diabetes mellitus is associated with loss of pancreatic b-cell L-type Ca2+ channel activity. Am J Physiol 270: E133-140, 1996 (1996)
  • Tang J, Pugh W, Polonsky K & Zhang H. Preservation of Insulin Secretory responses to P2-purinoceptor agonists in Zucker diabetic fatty rats. Am J Physiol 270: 270: E504-E512, 1996 (1996)
  • Macdonald MJ, Tang J & Polonsky KS. Low mitochondrial glycerol phosphate dehydrogenase and pyruvate cardoxylase in pancreatic islets of Zucker diabetic fatty rats. Diabetes 45: 1626-1630, 1996 (1996)
  • Rockow S, Tang J, Xiong W & Li W. Nck inhibits NGF and basic FGF induced PC12 cell differentiation via mitogen-activated protein kinase-independent pathway. Oncogen 12: 2351-2359, 1996 (1996)
  • Tokuyama Y, Sturis J, Depaoli A, Takeda J, Stoffel M, Tang J, Sun X, Polonsky K & Bell G. Evolution of b-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 44: 1447-1457, 1995 (1995)
  • Sturis J, Pugh WL, Tang J & Polonsky KS. Prevention of diabetes does not completely prevent insulin secretory defects in the ZDF rat. Am J Physiol 269: E786-E792, 1995 (1995)
  • Sturis J, Pugh WL, Tang J, Ostrega DM, Polonsky JS & Polonsky KS. Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat. Am J Physiol 267: E250-E259, 1994 (1994)
  • Ryan EA, Tobin BW, Tang J & Finegood DT. A new model for the study of mild diabetes during pregnancy. Diabetes 42: 316-323, 1993 (1993)

Abstract

  • Huang J, Lu w, Doycheva D, Gamdzyk M, Hu X, Liu R, Zhang JH, Tang J. IRE1α inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model. Journal of Neuroinflammation. 2020 May 6;17(1):152. (05/2020)

Scholarly Journals--Accepted

  • Ma Q, Huang B, Khatibi N, Rolland W, Suzuki H, Zhang JH and Tang J. PDGFR-α Inhibition Preserves Blood-Brain Barrier after Intracerebral Hemorrhage. Annals of Neurology. In press (2011)
  • Chen H, Burris M, Fajilan A, Spagnoli F, Zhang JH, Tang J. Prolonged Exposure to Isoflurane Ameliorates Infarction Severity in the Rat Pup Model of Neonatal Hypoxia-Ischemia. Translational Stroke Research. In press (2011)
  • Souvenir R, Fathali N, Ostrowski R, Lekic T, Zhang JH, Tang J. Tissue Inhibitor of Matrix Metalloproteinase Mediates Erythropoietin-induced Neuroprotection in Hypoxia Ischemia. Neurobiology of Disease. In press   (2011)

Book Review - Scholarly Journals--Published

  • Titova E, Ostrowski RP, Zhang JH, Tang J. Experimental models of subarachnoid hemorrhage for studies of cerebral vasospasm. Journal of Neurological Research. 31:568-581, 2009 (2009)