• This article describes the associated gap in nursing education on how to properly care for Transgender patients in the Undergraduate program in a Southern California university. Examining current research on transgender health and the university’s instruction on cultural competence, the creation of a simulation-based transgender patient who encounters Urosepesis is used to formerly educate nursing students on the appropriate ways to assess, communicate and intervene. Incorporating a multidisciplinary approach, nursing students were presented with a mid-fidelity mannikin to obtain a history and physical and later determine the appropriate level of care and resources needed. The aims of this simulation were to (a) identify signs and symptoms of Urosepsis, (b) incorporate the use of Team STEPPS, and (c) establish culturally sensitive care and self-awareness when treating a transgender client. Evaluation of the simulation design determined a need for further educational resources and teachings on transgender health. (01/2022)