Publications

Scholarly Journals--Published

  • Liu T, Zhang M, Mourkus A, Schroeder H, Zhang L, Power GG, Blood AB. Chronic high-altitude hypoxia alters iron and nitric oxide homeostasis in fetal and maternal sheep blood and aorta. Antioxidants 2022 Sep 15;11(9):1821. doi: 10.3390/antiox11091821 (2022)
  • Song R, Zhang L. Response by Song and Zhang to Letters Regarding Article, "MicroRNA-210 controls mitochondrial metabolism and protects heart function in myocardial infarction.” Circulation 146: e171-e172, 2022. (2022)
  • Hu X, Song R, Dasgupta C, Romero M, Juarez R, Hanson J, Blood AB, Wilson SM, Zhang L. MicroRNA-210-mediated mitochondrial reactive oxygen species confers hypoxia-induced suppression of spontaneous transient outward currents in ovine uterine arteries. Brit J Pharmacol 179: 4640-4654, 2022 (2022)
  • Li Y, Zhang Y, Walayat A, Fu Y, Liu B, Zhang L, Xiao D. The regulatory role of H19/miR-181a/ATG5 signaling in perinatal nicotine exposure-induced development of neonatal brain hypoxic-ischemic sensitive phenotype. Int J Mol Sci 2022 Jun 21;23(13):6885. doi: 10.3390/ijms23136885 (2022)
  • Hu X, Zhang L. Mitochondrial dysfunction in the pathogenesis of preeclampsia. Current Hypertension Report 2022 Mar 7. doi: 10.1007/s11906-022-01184-7 (2022)
  • Song R, Dasgupta C, Mulder C, Zhang L. MicroRNA-210 controls mitochondrial metabolism and protects heart function in myocardial infarction. Circulation 145: 1140-1153, 2022. PMCID: PMC9007902 (2022)
  • Reid C, Romero M, Glasgow S, Dobyns A, Chang S, Osman N, Puglisi J, Wilson CG, Blood AB, Hessinger DA, Zhang L, Wilson SM. Long term hypoxia negatively influences Ca2+ signaling in basilar arterial myocytes of fetal and adult sheep. Front Physiol, 2022 Jan 18;12:760176. doi: 10.3389/fphys.2021.760176. eCollection 2021. PMCID: PMC8804533 (2022)
  • Hu X, Zhang L. Hypoxia and reprogramming of mitochondrial metabolism and oxidative stress in vascular dysfunction. Antioxidants 2021 Mar 8;10(3):405. doi: 10.3390/antiox10030405. PMCID: PMC7999178 (2021)
  • Song R, Hu XQ, Romero M, Holguin MA, Kagabo W, Xiao D, Wilson SM, Zhang L. Ryanodine receptor subtypes regulate Ca2+ sparks/spontaneous transient outward currents and myogenic tone of uterine arteries in pregnancy. Cardiovasc Res 117: 792-804, 2021. PMCID: PMC7898951 (2021)
  • Ma Q, Dasgupta C, Li Y, Zhang L. MicroRNA-210 downregulates TET2 and contributes to inflammatory response in neonatal hypoxic-ischemic brain injury. J Neuroinflammation, 2021 Jan 5;18(1):6. doi: 10.1186/s12974-020-02068-w. PMCID: PMC7786974 (2021)
  • Hu X, Dasgupta C, Song R, Romero M, Wilson SM, Zhang L. MicroRNA-210 mediates hypoxia-induced repression of spontaneous transient outward currents in uterine arteries during gestation. Hypertension 77:1412-1427, 2021. PMCID: PMC7946727 (2021)
  • Leslie E, Lopez V, Anti N, Alvarez R, Kafeero I, Welsh DG, Romero M, Kaushal S, Brito A, La Frano MR, Johnson C, Bosviel R, Blazenovic I, Song R, Zhang L, Newman J, Feihn O, Wilson SM. Gestational long-term hypoxia induces metabolomic reprogramming and phenotypic transformations in fetal sheep pulmonary arteries. Am J Physiol Lung Cellular and Molecular Physiology, 320: L770-L784, 2021. PMCID: PMC8174832 (2021)
  • Tong Y, Zhang S, Riddle S, Zhang L, Song R, Yue D,. Intrauterine hypoxia and epigenetic programming in lung development and disease. Biomedicines 2021 Aug 2;9(8):944. doi: 10.3390/biomedicines9080944. PMCID: PMC8394854 (2021)
  • Hu X, Zhang L. Hypoxia and integrated stress response promote pulmonary hypertension and preeclampsia: implications in drug development. Drug Discovery Today 26:2754-2773, 2021. PMC8612951 (2021)
  • Shen G, Hu S, Zhao Z, Zhang L, Ma Q. C-type natriuretic peptide ameliorates vascular injury and improves neurological outcome in neonatal hypoxic-ischemic brain injury in mice. Int J Mol Sci 2021 Aug 20;22(16):8966.  doi: 10.3390/ijms22168966. PMCID: PMC8396645 (2021)
  • Hu X, Zhang L. Uteroplacental circulation in normal pregnancy and preeclampsia: functional adaptation and maladaptation. Int J Mol Sci 2021 Aug 11;22(16):8622. doi: 10.3390/ijms22168622. PMCID: PMC8395300 (2021)
  • Zhang Y, Yang M, Li Y, Liu B, Zhang L, Xiao D. Inhibition of DNA methylation in newborns reprograms ischemia-sensitive biomarkers resulting in development of a heart ischemia-sensitive phenotype late in life. Reproductive Toxicology 105:198-210, 2021. doi: 10.1016/j.reprotox.2021.09.007. PMCID: PMC8511209 (2021)
  • Walayat A, Li Y, Zhang Y, Fu Y, Liu B, Shao XM, Zhang L, Xiao D. Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 321: R791-R801, 2021. doi: 10.1152/ajpregu.00207.2021. PMCID: PMC8616627 (2021)
  • Zhang P, Li Y, Fu Y, Huang L, Liu B, Qin S, Zhang, D, Zhang L, Shao XM, Xiao D. Inhibition of autophagy signaling via 3-methyladenine rescued nicotine-mediated cardiac pathological effects and heart dysfunctions. Int J Biol Sci 16: 1349-1362, 2020.  PMCID: PMC7085229 (2020)
  • Bonnet S, Boucherat O, Paulin R, Wu D, Hindmarch CCT, Archer SL, Song R, Moore JB, Provencher S, Zhang L, Uchida S. Clinical values of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases. Am J Physiol Cell Physiol 318: C1-C28, 2020. PMCID: PMC6986837 (2020)
  • Meng X, Zhang P, Zhang L. Fetal Hypoxia Impacts on Proliferation and Differentiation of Sca-1+ Cardiac Progenitor Cells and Maturation of Cardiomyocytes: A Role of MicroRNA-210. Genes (Basel). 2020 Mar 20;11(3):328. doi: 10.3390/genes11030328. PMCID: PMC7140790 (2020)
  • Feng X, Li X, Yang C, Ren Q, Li N, Zhang L, Zhou X, Xu Z. Maternal high-sucrose diet accelerated vascular stiffness in aged offspring via suppressing Cav1.2 and contractile phenotype of VSMCs. Molecular Nutrition & Food Research, 2019 May 8:e1900022. doi: 10.1002/mnfr.201900022. [Epub ahead of print]. PMID: 31067604 (2020)
  • Li B, Dasgupta C, Huang L, Meng X, Zhang L. MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy. Cell Mol Immunol 17: 976-991, 2020. PMCID: PMC7608107 (2020)
  • Song R, Zhang L. Cardiac ECM: its epigenetic regulation and role in heart development and repair. Int J Mol Sci 2020 Nov 15;21(22):8610. doi: 10.3390/ijms21228610.  PMCID: PMC7698074 (2020)
  • Hu XQ, Song R, Romero M, Dasgupta C, Hatcher D, Xiao D, Blood AB, Wilson SM, Zhang L. Gestational hypoxia inhibits pregnancy-induced upregulation of Ca2+ sparks and spontaneous transient outward currents in uterine arteries via heightened endoplasmic reticulum/oxidative stress. Hypertension 76: 930-942, 2020. PMCID: PMC7429261 (2020)
  • Shen G, Hu S, Zhao Z, Zhang L, Ma Q. Antenatal hypoxia accelerates the onset of Alzheimer's disease pathology in 5xFAD mouse model. Front Aging Neurosci 2020 Aug 21;12:251. doi: 10.3389/fnagi.2020.00251. eCollection. PMCID: PMC7472639 (2020)
  • Jian J, Zhang P, Li Y, Liu B, Zhang Y, Zhang L, Shao XM, Zhuang J, Xiao D. Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype late in life. Theranostics 10: 11820-11836, 2020. PMCID: PMC7546014 (2020)
  • Patterson AJ, Choe D, Song MA, Xiao D, Foster G, Zhang L. Early detection of coronary artery disease by micro-RNA analysis in asymptomatic patients stratified by coronary CT angiography. Diagnostics 2020 Oct 28;10(11):E875. doi: 10.3390/ diagnostics10110875. PMCID: PMC7693112 (2020)
  • Lv J, Ma Q, Dasgupta C, Xu Z, Zhang L. Antenatal hypoxia and programming of glucocorticoid receptor expression in the adult rat heart. Front Physiol 02 April 2019 | https://doi.org/10.3389/fphys.2019.00323 (IF: 4.134) PMCID: PMC6454194 (2019)
  • Li B, Meng X, Zhang L. MicroRNAs and Cardiac Stem Cells in Heart Development and Disease. Drug Discovery Today 24: 233-240, 2019.  PMCID: PMC6261710 (2019)
  • Huang L, Zhang L. Neural stem cell therapies and hypoxic-ischemic brain injury. Progress in Neurobiology 173: 1-17, 2019 PMCID: PMC6249121 (2019)
  • Zhang P, Ke J, Li Y, Huang L, Chen Z, Huang X, Zhang L, Xiao D. Long-term exposure to high altitude hypoxia during pregnancy increases fetal heart susceptibility to ischemia/reperfusion injury and cardiac dysfunction. International J of Cardiology 274: 7-15, 2019.  with an Editorial Comment PMCID: PMC6242757 (2019)
  • Huang L, Chen X, Dasgupta C, Chen W, Song R, Wang C, Zhang L. Fetal hypoxia impacts methylome and transcriptome in developmental programming of heart disease. Cardiovas Res 115: 1306-1319, 2019. PMCID: PMC6587923 (2019)
  • Hu XQ, Song R, Romero M, Dasgupta C, Huang X, Holguin MA, Williams V, Xiao D, Wilson SM, Zhang L. Pregnancy increases Ca2+ sparks/STOCs and reduces uterine arterial myogenic tone. Hypertension 73: 691-702, 2019. PMCID: PMC6374197 (2019)
  • Hu XQ, Song R, Zhang L. Effect of oxidative stress on estrogen-NOS-KCa pathway in uteroplacental dysfunction: its implication in pregnancy complications. Oxidative Medicine and Cellular Longevity 2019 Feb 10;2019: 9194269. doi: 10.1155/2019/9194269. eCollection 2019. PMCID: PMC6387699 (2019)
  • Ma Q, Dasgupta C, Li Y, Huang L, Zhang L. MicroRNA-210 downregulates ISCU and induces mitochondrial dysfunction and neuronal death in neonatal hypoxic-ischemic brain injury. Mol Neurobiol 56: 5608-5625, 2019. PMCID: PMC6873808 (2019)
  • Liu B, Hu X, Li Y, Ke J, Dasgupta C, Chen Z, Huang X, Zhang P, Walayat A, Zhang L, Xiao D. Epigenetic down-regulation of BKCa channel by miR-181a contributes to the perinatal nicotine-mediated exaggerated coronary vascular tone in adult life. International Journal of Cardiology 281: 82-89, 2019. PMCID: PMC6392075 (2019)
  • Song R, Hu XQ, Zhang L. Glucocorticoids and programming of microenvironment in the heart development and function. Journal of Endocrinology, 242: T121-TT133, 2019. PMCID: PMC6602534 (2019)
  • Chen X, Zhang L, Wang C. Antenatal hypoxia-induced epigenomic reprogramming and alteration of gene transcription in the rat fetal and adult offspring heart. Sci Data 2019 Oct 29;6(1):238. doi: 10.1038/s41597-019-0253-9. PMCID: PMC6820751 (2019)
  • Ma Q, Zhang L, Pearce WJ. MicroRNAs in brain development and cerebrovascular pathophysiology. Am J Physiol Cell Physiol 317: C3-C19, 2019. PMCID: PMC6689752 (2019)
  • Chen Z, Gong L, Zhang P, Li Y, Liu B, Zhang L, Zhuang J, Xiao D. Epigenetic down-regulation of Sirt 1 via DNA methylation and oxidative stress signing contributes to the gestational diabetes mellitus-induced fetal programming of heart ischemia-sensitive phenotype in late life. International Journal of Biological Sciences, 15: 1240-1251, 2019. PMCID: PMC6567811 (2019)
  • Knox-Concepcion K, Figueroa J, Hartman R, Li Y, Zhang L. Repression of the glucocorticoid receptor increases hypoxic-ischemic brain injury in a sex-dependent manner in male neonatal rats. Int J Mol Sci 2019 Jul 16;20(14). pii: E3493. doi: 10.3390/ijms20143493. PMCID: PMC6678481 (2019)
  • Li Y, Song AM, Fu Y, Walayat A, Yang M, Jian J, Liu B, Xia L, Zhang L, Xiao D. Perinatal nicotine exposure alters AKT/GSK-3β/mTOR/autophagy signaling leading to development of hypoxic-ischemia sensitive phenotype in rat neonatal brain. Am J Physiol Regul Integr Comp Physiol 317: R803-R813, 2019. PMCID: PMC6962626 (2019)
  • Hu XQ, Zhang L. MicroRNAs in uteroplacental vascular dysfunction. Cells 2019 Oct 29;8(11). pii: E1344. doi: 10.3390/cells8111344. PMCID: PMC6912833 (2019)
  • Rood K, Lopez V, La Frano MR, Fiehn O, Zhang L, Blood AB, Wilson SM. Gestational hypoxia and programing of lung metabolism. Front Physiol 2019, 10.3389/fphys.2019.01453. PMCID: PMC6895135 (2019)
  • Moretta D, Papamatheakis DG, Morris DP, Giri PC, Blood Q, Murray S, Ramzy M, Romero M, Vemulakonda S, Lauw S, Longo LD, Zhang L, Wilson SM. Long-term high-altitude hypoxia and alpha adrenoceptor-dependent pulmonary arterial contractions in fetal and adult sheep. Front Physiol 2019 Aug 28;10:1032. doi: 10.3389/fphys.2019.01032. eCollection 2019. PMCID: PMC6723549 (2019)
  • Song R, Hu XQ, Zhang L. Mitochondrial miRNA in cardiovascular function and disease. Cells 2019 Nov 21;8(12). pii: E1475. doi: 10.3390/cells8121475. PMCID: PMC6952824 (2019)
  • Gao Y, Dasgupta C, Huang L, Song R, Zhang Z, Zhang L. Multi-omics integration reveals short and long-term effects of gestational hypoxia on the heart. Cells 2019 Dec 11;8(12). pii: E1608. doi: 10.3390/cells8121608. PMCID: PMC6952773 (2019)
  • Huang L, Ma Q, Li Y, Li B, Zhang L. Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice. Exp Neurol 300: 41-50, 2018. PMCID: PMC6089227 (2018)
  • Shin AP, Han L, Dasgupta C, Huang L, Yang S, Zhang L. SIRT1 increases cardiomyocyte binucleation in the heart development. Oncotarget 9(8): 7996-8010, 2018. PMCID: PMC5814276 (2018)
  • Shen CP, Romero M, Brunelle A, Wolfe C, Blood Q, Dobyns A, Francis M, Taylor MS, Puglisi JL, Longo LD, Zhang L, Wilson CG, Wilson SM. Long-Term High Altitude Hypoxia influences Pulmonary Arterial L-type Calcium Channel mediated Ca2+ signals and Contraction in Fetal and Adult Sheep. Am J Physiol Regul Integr Comp Physiol. 314: R433-R446, 2018. PMCID: PMC5899247 (2018)
  • Ducsay C, Goyal R, Pearce WJ, Wilson S, Hu X, Zhang L. Gestational hypoxia and developmental plasticity. Physiological Reviews 98: 1241-1334, 2018. PMCID: 6088145 (2018)
  • Ma Q, Zhang L. C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2. Exp Neurol 304: 58-66, 2018. PMCID: PMC6089427 (2018)
  • Mata-Greenwood E, Blood A, Sands L, Bragg S, Xiao D, Zhang L. A novel rodent model of pregnancy complications associated with genetically determined angiotensin converting enzyme (ACE) activity. American Journal of Physiology-Endocrinology and Metabolism 315: E52-E62, 2018. PMCID: PMC6087725 (2018)
  • Blum-Johnston C, Thorpe RB, Wee C, Romero M, Brunelle A, Blood Q, Wilson R, Blood AB, Francis M, Taylor MS, Zhang L, Longo LD, Pearce WJ, Wilson SM. Long term hypoxia uncouples Ca2+ and eNOS in bradykinin-mediated pulmonary arterial relaxation. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 314: R870-R882, 2018. PMCID: PMC6032299 (2018)
  • Zhang Y, Zhang M, Li L, Wei B, He A, Lu L, Li X, Zhang L, Xu Z, Sun M. Methylation-reprogrammed Wnt/β-catenin signaling mediated prenatal hypoxia-induced brain injury in fetal and offspring rats. J Cell Mol Med 22: 3866-3874, 2018. PMCID: PMC6050486 (2018)
  • Hu XQ, Dasgupta C, Xiao J, Yang S, Zhang L. Gestational hypoxia suppresses large conductance Ca2+-activated K+ channel function in uterine arteries: A causal role of microRNA-210. J Physiol 596.23 pp 5891-5906, 2018, with an Editorial Comment from Dino. PMCID: PMC6265561 (2018)
  • Li Y, Hung L, Ma Q, Concepcion KR, Song MA, Zhang P, Fu Y, Xiao D, Zhang L. Repression of glucocorticoid receptor aggravates acute ischemic brain injury in adult mice. International Journal of Molecular Sciences 2018, 19, 2428; doi:10.3390/ijms19082428. PMCID: PMC6121696 (2018)
  • Li Y, Zhang W, Shi R, Sun M, Zhang L, Li N, Xu Z. Prenatal caffeine damaged leaning and memory in rat offspring mediated by ARs/PKA/CREB/BDND pathway. Physiol Res 67: 975-983, 2018. PMID: 30204465 (2018)
  • Concepcion KR, Zhang L. Corticosteroids and Perinatal Hypoxic-Ischemic Brain Injury. Drug Discovery Today 23: 1718-1732, 2018. PMCID: PMC6440944 (2018)
  • Martinez SR, Ma Q, Dasgupta C, Zhang L. miR-210 suppresses glucocorticoid receptor expression in response to hypoxia in fetal rat cardiomyocytes. Oncotarget 8(46): 80249-80264 2017. PMCID: PMC5655194 (2017)
  • Li Y, Ma Q, Halavi S, Hartman RE, Xiao D, Zhang L. Inhibition of DNA methylation in the developing rat brain disrupts sexually dimorphic neurobehavioral phenotypes in adulthood. Mol Neurobiol 54: 3988-3999, 2017. PMCID: PMC5161729 (2017)
  • Wang L, Ke J, Li Y, Ma Q, Dasgupta C, Huang X, Zhang L, Xiao D. Inhibition of miRNA-210 reverses nicotine-induced brain hypoxic-ischemic injury in neonatal rats. Int J Biol Sci 13: 76-84, 2017. PMCID: PMC5264263 (2017)
  • Harding B, Conception K, Li Y, Zhang L. Glucocorticoids protect neonatal rat brain in model of hypoxic-ischemic encephalopathy (HIE). Int J Mol Sci 2017, 18(1), 17; doi:10.3390/ijms18010017 PMCID: PMC5297652 (2017)
  • Tenayuca J, Cousins K, Yang S, Zhang L. Computational modeling approach in probing effects of cytosine methylation on the transcription factor binding to DNA. Curr Top Med Chem 17: 1778-1787, 2017. PMCID: PMC5639940 (2017)
  • Zhang L. Medicinal chemistry of molecular and epigenetic targets and drug development. Curr Top Med Chem 17: 1669, 2017. (2017)
  • Hu X, Chen M, Dasgupta C, Xiao D, Huang X, Yang S, Zhang L. Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca2+-activated K+ channel function in uterine arteries. Biol Reprod 96: 424-434, 2017. PMCID: PMC6366546 (2017)
  • Gao Q, Tang J, Li N, Zhou X, Li Y, Liu Y, Wu J, Yang Y, Shi R, He A, Li X, Zhang Y, Chen J, Zhang L, Sun M, Xu Z. A novel mechanism of angiotensin II-regulated placental vascular tone in the development of hypertension in preeclampsia. Oncotarget 8: 30734-30741, 2017. PMCID: PMC5458163 (2017)
  • Hu XQ, Dasgupta C, Chen M, Xiao D, Huang X, Han L, Yang S, Xu Z, Zhang L. Pregnancy reprograms large-conductance Ca2+-activated K+ channel in uterine arteries: roles of Ten-Eleven Translocation Methylcytosine Dioxygenase 1-mediated active demethylation. Hypertension 69: 1181-1191, 2017. PMCID: PMC5426984 (2017)
  • Shin AN, Dasgupta C, Zhang G, Seal K, Zhang L. Proteomic analysis of endothelin-1 targets in the regulation of cardiomyocyte proliferation. Curr Top Med Chem 17: 1788-1802, 2017. PMCID: PMC5649443 (2017)
  • Hu X, Zhang L. Angiogenesis during pregnancy: All routes lead to MAPKs. J Physiol 595: 4571-4572, 2017. PMCID: PMC5509881 (2017)
  • Ma Q, Zhang L. MicroRNA 210 and mitochondrial pathway in neonatal hypoxic-ischemic encephalopathy. Oncotarget 8: 38078-38079, 2017. PMCID: PMC5503514 (2017)
  • Ma Q, Dasgupta C, Li Y, Huang L, Zhang L. MicroRNA-210 suppresses junction proteins and disrupts blood-brain barrier integrity in neonatal rat hypoxic-ischemic brain injury. International Journal of Molecular Sciences 2017 Jun 24;18(7). pii: E1356. doi: 10.3390/ijms18071356. PMCID: PMC5535849 (2017)
  • Hu XQ, Dasgupta C, Xiao D, Huang X, Yang S, Zhang L. Micro RNA-210 targets TET1 and suppresses pregnancy-mediated adaptation of BKCa channel expression and function in ovine uterine arteries. Hypertension 70: 601-612, 2017. PMCID: PMC5783798 (2017)
  • He A, Zhang Y, Li L, Feng X, Wei B, Zhu D, Liu Y, Wu L, Zhang L, Xu Z, Sun M. Long-term influence of prenatal high sucrose intake on learning and memory of aged rat offspring with oxidative stress and disruptions in NMDARs/Wnt signaling in hippocampus. Brain Res 1169: 114-121, 2017. PMCID: PMC5639946 (2017)
  • Shamloo K, Chen J, Sardar J, Sherpa RT, Pala R, Atkinson KF, Pearce WJ, Zhang L, Nauli SM. Chronic hypobaric hypoxia modulates primary cilia differently in adult and fetal ovine kidneys. Frontiers in Physiology September 2017 Volume 8: Article 677, doi: 10.3389/fphys.2017.00677. PMCID: PMC5611369 (2017)
  • Ke J, Dong N, Wang L, Li Y, Dasgupta C, Zhang L, Xiao D. Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring. Oncotarget 8: 76865-76880, 2017 PMCID: PMC5652749 (2017)
  • Zhang P, Lv J, Li Y, Zhang L, Xiao D. Neonatal lipopolysaccharide exposure gender-dependently increases heart susceptibility to ischemia/reperfusion injury in male rats. International Journal of Medical Sciences 14: 1163-1172, 2017. PMCID: PMC5666548 (2017)
  • Li B, Concepcion K, Meng X, Zhang L. Brain-immune interactions in perinatal hypoxic-ischemic brain injury. Progress in Neurobiology 159: 50-68, 2017. PMCID: PMC5831511 (2017)
  • Xiong F, Lin T, Song M, Ma Q, Martinez S, Lv J, Matagreenwood E, Xiao D, Xu Z, Zhang L. Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart. J Mol Cell Cardiol 91: 160-171, 2016. PMCID: PMC4764467 (2016)
  • Li Y, Ma Q, Halavi S, Hartman RE, Obenaus A, Xiao D, Zhang L. Inhibition of DNA methylation in the developing brain increases brain susceptibility to hypoxic-ischemic injury in neonatal rats. Exp Neurol 275: 1-10, 2016.  PMCID: PMC4785034 (2016)
  • Hu X, Huang X, Xiao D, Zhang L. Direct effect of chronic hypoxia in suppressing large conductance Ca2+-activated K+ channel activity in ovine uterine arteries via increasing oxidative stress. J Physiol 594.2: 343–356, 2016. PMCID: PMC4713733 (2016)
  • Ma Q, Dasgupta C, Li Y, Mistry N, Xiong F, Hartman R, Zhang L. Inhibition of miRNA-210 provides neuroprotection and improves long-term neurological function recovery in hypoxic-ischemic brain injury in neonatal rats. Neurobiol Dis 89: 202-212, 2016. PMCID: PMC4785034 (2016)
  • Gao Q, Zhu X, Chen J, Mao C, Zhang L, Xu Z. Upregulation of P53 promoted G1 arrest and apoptosis in human umbilical cord vein endothelial cells from preeclampsia. J Hypertens 34: 1380-1388, 2016. PMCID: PMC5649442 (2016)
  • Zhu Z, Tang J, Zhou X, Xiang S, Zhu X, Li N, Shi R, Zhong Y, Zhang L, Sun M, Xu Z. Roles of ion channels in regulation of acetylcholine-mediated vasoconstrictions in umbilical cords of rabbit/rats. Reprod Toxicol 65: 95-103, 2016. PMCID: PMC5638043 (2016)
  • Xiao D, Wang L, Huang XH, Li Y, Dasgupta C, Zhang L. Protective effect of antenatal antioxidant on nicotine-induced heart ischemia-sensitive phenotype in rat offspring. PLoS One 11: e0150557, 2016. PMCID: PMC4769226 (2016)
  • Gay MS, Dasgupta C, Li Y, Zhang L. Epigenetic repression of cyclin D2 mediates dexamethasone-induced cardiomyocyte terminal differentiation. J Pharmacol Exp Ther 358: 190-198, 2016. PMCID: PMC4959091 (2016)
  • Ma Q, Zhang L. Nutritional stress and fetal epigenetics in the brain. The Handbook of Nutrition, Diet and Epigenetics submitted 10/10/16. (2016)
  • Paradis AN, Gay M, Wilson CG, Zhang L. Newborn hypoxia/anoxia decreases cardiomyocyte proliferation and endowment in the developing heart: role of endothelin-1. PLoS One 10: e0116600, 2015.   PMCID: PMC4414482 (2015)
  • Ma Q, Zhang L. Epigenetic Programming of Hypoxic-Ischemic Encephalopathy in Response to Fetal Hypoxia. Progress in Neurobiology 124: 28-48, 2015. PMCID: PMC4272655 (2015)
  • Xia S, Lv J, Gao Q, Li L, Chen N, Wei X, Xiao J, Chen J, Tao J, Sun M, Mao C, Zhang L, Xu Z. Prenatal exposure to hypoxia induced Beclin 1 signaling-mediated renal autophagy and altered renal development in rat fetuses. Reprod Sci 22: 156-164, 2015.   PMCID: PMC4287595 (2015)
  • Song M, Paradis AN, Gay MS, Shin J, Zhang L. Differential expression of microRNAs in ischemic heart disease. Drug Discovery Today 20: 223-235, 2015.   PMCID: PMC4336590 (2015)
  • Shi L, Zhang H, Chen Y, Liu Y, Lu N, Zhao T, Zhang L. Chronic exercise normalizes changes of Cav 1.2 and KCa 1.1 channels in mesenteric arteries from spontaneously hypertensive rats. Br J Pharmacol 172: 1846-1858, 2015. PMCID: PMC4376461 (2015)
  • Martinez SR, Gay MS, Zhang L. Epigenetic mechanisms in the heart development and disease. Drug Discovery Today 20: 799-811, 2015. PMID: 25572405 (2015)
  • Mata-Greenwood E, Jackson PN, Pearce WJ, Zhang L. Endothelial GR transcriptional regulation according to dexamethasone sensitivity. J Mol Endocrinol 55: 133-146, 2015. PMCID: PMC5113289 (2015)
  • Gay MS, Li Y, Xiong F, Lin T, Zhang L. Dexamethasone treatment of newborn rats decreases cardiomyocyte endowment in the developing heart through epigenetic modifications. PLoS One 10:e0125033, 2015.  PMCID: PMC4414482 (2015)
  • Chen M, Xiao D, Hu XQ, Dasgupta C, Yang S, Zhang L. Hypoxia represses ERα expression and inhibits estrogen-induced regulation of BKca channel activity and myogenic tone in ovine uterine arteries: the causal role of DNA methylation. Hypertension 66: 44-51, 2015.  PMCID: PMC4465851 (2015)
  • Shi L, Liao J, Liu B, Zeng F, Zhang L. Mechanisms and therapeutic potential of microRNAs in hypertension. Drug Discovery Today 20: 1188-1204, 2015. PMCID: PMC4609581 (2015)
  • Xue Q, Patterson AJ, Xiao D, Zhang L. Estrogen regulates angiotensin II receptor expression patterns and protects the heart from ischemic injury in female rats. Biol Reprod 93(1):6, 1-9, 2015. PMCID: PMC4706310 (2015)
  • Song M, Dasgupta C, Zhang L. Chronic losartan treatment up-regulates AT1R and increases the heart vulnerability to acute onset of ischemia and reperfusion injury in male rats. PLoS One 10(7):e0132712, 2015. PMCID: PMC4500443 (2015)
  • Xiao D, Huang X, Li Y, Dasgupta C, Wang L, Zhang L. Antenatal antioxidant prevents nicotine-mediated hypertensive response in rat adult offspring. Biol Reprod 93(3):66, 1-8, 2015. PMCID: PMC4710188 (2015)
  • González P, Xiong F, Li Y, Zhang L. Fetal hypoxia increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of glucocorticoid receptors. Neurobiol Dis 65: 172-179, 2014.   PMCID: PMC3990589 (2014)
  • Paradis AN, Gay MS, Zhang L. Binucleation of cardiomyocytes: the transition from a proliferative to a terminally differentiated state. Drug Discovery Today, 19: 602-609, 2014. PMCID: PMC4007385 (2014)
  • Xiao D, Dasgupta C, Chen M, Zhang K, Buchholz J, Xu Z, Zhang L. Inhibition of DNA Methylation Reverses Norepinephrine-Induced Cardiac Hypertrophy in Rats. Cardiovasc Res 101: 373-382, 2014. PMCID: PMC3927999 (2014)
  • Goyal R, Zhang L, Blood A, Baylink DJ, Longo LD, Oshiro B, Mata-Greenwood E. Characterization of an animal model of pregnancy-1 induced vitamin D deficiency due to metabolic gene dysregulation. Am J Physiol Endo 306: E256-E266, 2014. PMID: 24326417 (2014)
  • Paradis AN, Xiao D, Zhou J, Zhang L. Endothelin-1 promotes cardiomyocyte terminal differentiation in the developing heart via heightened DNA methylation. Int J Med Sci 11: 373-380, 2014. PMCID: PMC3936032 (2014)
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  • Mao C, Ding Y, Zhou, Zhang H, Xu Z, Zhang L. Changes of renal AT1/AT2 receptors and structures in ovine fetuses following exposure to long-term hypoxia. Am J Nephrol, 31: 141-150, 2010.  PMCID: PMC2853592 (2010)
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  • Xiao D, Huang X, Longo LD, Zhang L. PKC regulates a1-adrenoceptor-mediated contractions and baseline Ca2+ sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to high altitude hypoxia. High Altitude Med Biol 11: 153-162, 2010. PMCID: PMC3114155 (2010)
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  • Monau TR, Vargas VE, Zhang L, Myers DA, Ducsay CA. Nitric oxide inhibits ACTH-induced cortisol production in near term, long-term hypoxic ovine fetal adrenocortical cells. Reprod Sci 17: 955-962, 2010.  PMCID: PMC2943550 (2010)
  • Charles SM, Zhang L, Cipolla MJ, Buchholz JN, Pearce WJ. Roles of cytosolic Ca2+ concentration and myofilament Ca2+ sensitization in age-dependent cerebrovascular myogenic tone. Am J Physiol Heart Circ Physiol 299: H1034-H1044, 2010. PMCID: PMC2957359 (2010)
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  • Xiao D, Longo LD, Zhang L. Role of KATP and L-type Ca2+ Channel Activities in Regulation of Ovine Uterine Vascular Contractility: Effect of Pregnancy and Chronic Hypoxia. Am J Obstet Gynecol 203: 596.e6-596.e12, 2010.  PMCID: PMC2993850 (2010)
  • Xu F, Mao C, Ding Y, Rui C, Wu L, Shi A, Zhang L, Xu Z. Molecular and enzymatic profiles of mammalian DNA methyltransferases: structures and targets for drugs. Current Medicinal Chemistry 17: 4052-4071, 2010. PMCID: PMC3003592 (2010)
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  • Xu F, Mao C, Liu Y, Wu L, Xu Z, Zhang L. Losartan chemistry and its effects via AT1 mechanisms in the kidney. Current Medicinal Chemistry 16: 3701-3715, 2009. PMCID: PMC2819278 (2009)
  • Xu F, Mao C, Hu Y, Rui C, Xu Z, Zhang L. Cardiovascular effects of losartan and its relevant clinical application. Current Medicinal Chemistry 16: 3841-3857, 2009. PMCID: PMC2819278 (2009)
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  • Williams JM, White CR, Chang MM, Injeti ER, Zhang L, Pearce WJ. Chronic hypoxic decreases in soluble guanylate cyclase protein and enzyme activity are age-dependent in fetal and adult ovine carotid arteries. J Appl Physiol 100: 1857-1866, 2006. PMID: 16469937 (2006)
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  • Zhang L. Prenatal hypoxia and cardiac programming.  J Soc Gynecol Invest 12: 2-13, 2005. PMID: 15629664 (2005)
  • Li G, Xiao YH, Zhang L. Cocaine induces apoptosis in fetal rat myocardial cells through the p38 MAPK and mitochondrial/cytochrome c pathways. J Pharmacol Exp Ther 312: 112-119, 2005. PMID: 15365088 (2005)
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  • He J, Yang S, Zhang L. Effects of cocaine on nitric oxide production in bovine coronary artery endothelial cells.  J Pharmacol Exp Ther 314: 980-986, 2005. PMID: 15919765 (2005)
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  • Bird IM, Zhang L, Magness RR. Possible mechanisms underlying pregnancy induced increases in uterine artery endothelial function. Am J Physiol 284: R245-R258, 2003. PMID: 12529278 (2003)
  • Mbaku EM, Zhang L, Pearce WJ, Duckles SP, Buchholz J. High Altitude Chronic Hypoxia Alters the Function of NOS Neurons in Cerebral Arteries of Near-Term Fetal and Adult Sheep. J Appl Physiol 94: 724-732, 2003. PMID: 12433849 (2003)
  • Li G, Xiao YH, Estrella JL, Ducsay CA, Gilbert RD, Zhang L. Effect of prenatally chronic hypoxia on heart susceptibility to ischemia/reperfusion injury in adult rat. J Soc Gynecol Invest 10: 265-274. 2003. with Editorial Comment. PMID: 12853087 (2003)
  • White M, Zhang L. Effects of Chronic Hypoxia on Maternal Vasodilation and Vascular Reactivity in Guinea Pig and Ovine Pregnancy. High Alt Med Biol 4: 157-169, 2003. PMID: 12855049 (2003)
  • Mlynarczyk M, Imamura T, Umezaki H, Kaushal KM, Zhang L, Ducsay CA. Long-term hypoxia changes myometrial responsiveness and oxytocin receptors in the pregnant ewe: differential effects on longitudinal vs. circular smooth muscle. Biol Reprod 69: 1500-1505, 2003.  PMID: 12855597 (2003)
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  • Zhang L. Fetal origins of adult disease. Proc West Pharmacol Soc 46: 9-10, 2003. PMID: 14699875 (2003)
  • Bae S, Xiao YH, Li G, Casiano C, Zhang L. Effect of Maternal Chronic Hypoxic Exposure during Gestation on Apoptosis in Fetal Rat Heart. Am J Physiol Heart Circ Physiol 285: H983-H990, 2003. PMID: 12750058 (2003)
  • Bishai JM, Meulenaar R, Penninga L, Nijland R, Gheorghe CP, Zhao Y, Buchholz JN, Zhang L, Longo LD. Pre- and post-junctional a2-adrenergic receptors in fetal and adult ovine cerebral arteries. Am J Physiol 282: R1654-R1662, 2002. PMID: 12010747 (2002)
  • Long W, Zhang L, Longo LD. Fetal and adult cerebral artery KATP- and KCa-channel responses to long-term hypoxia. J Appl Physiol 92: 1692-1701, 2002. PMID: 11896039 (2002)
  • Xiao D-L, Zhang L. ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy. Am J Physiol 282: H292-300, 2002.  PMID: 11748074 (2002)
  • Xiao D-L, Huang XH, Bae S, Ducsay CA, Zhang L. Cortisol-Mediated Potentiation of Uterine Artery Contractility: Effect of Pregnancy. Am J Physiol 283: H238-H246, 2002. PMID: 12063296 (2002)
  • Blood AB, Zhao Y, Long W, Zhang L, Longo LD. L-type Ca2+ channels in adult and fetal cerebral arteries. Am J Physiol 282: R131-R138, 2002. PMID: 11742831 (2002)
  • Angeles DM, Williams J, Purdy RE, Zhang L, Pearce WJ. Effects of maturation and acute hypoxia on receptor-IP3 coupling in ovine common carotid arteries. Am J Physiol 280: R410-R417, 2001. PMID: 11208569 (2001)
  • Xiao Y-H, Xiao D-L, He J, Zhang L. Maternal cocaine administration during pregnancy induces apoptosis in fetal rat heart. J Cardiovas Pharmacol 37: 639-648, 2001. PMID: 11392460 (2001)
  • Nauli SM, Zhang L, Pearce WJ. Maturation depresses cGMP-mediated decreases in [Ca2+]i and Ca2+ sensitivity in ovine cranial arteries. Am J Physiol 280: H1019-H1028, 2001. PMID: 11179043 (2001)
  • Xiao D-L, Bird IM, Magness RR, Longo LD, Zhang L. Upregulation of eNOS in pregnant ovine uterine arteries by chronic hypoxia. Am J Physiol 280: H812-H820, 2001. PMID: 11158981 (2001)
  • Di T, Sullivan JA, Magness RR, Zhang L, Bird IM. Pregnancy-specific enhancement of agonist-stimulated ERK-1/2 signaling in uterine artery endothelial cells increases Ca2+ sensitivity of endothelial nitric oxide synthase as well as cytosolic phospholipase A2. Endocrinology 142: 3014-3026, 2001. PMID: 11416023 (2001)
  • Xiao D-L, Pearce WJ, Zhang L. Pregnancy increases endothelium-dependent relaxation of ovine uterine artery: role of nitric oxide and intracellular calcium. Am J Physiol 281: H183-H190, 2001. PMID: 11406484 (2001)
  • He J, Xiao Y, Zhang L. Cocaine-induced apoptosis in bovine coronary artery endothelial cells: role of nitric oxide.  J Pharmacol Exp Ther 298: 180-187, 2001. PMID: 11408540 (2001)
  • Nauli SM, Zhang L, Gerthoffer WT, Pearce WJ. Maturation attenuates the effects of cGMP on contraction, [Ca2+]i and Ca2+ sensitivity in ovine basilar arteries. Gen Pharmacol: The Vascular System 35: 1-12,2001. PMID: 11707317 (2001)
  • Nauli SM, Akopov SE, Zhang L, Pearce WJ. Developmental changes in ryanodine- and IP3-sensitive Ca2+ pools in the ovine basilar artery. Am J Physiol 281: C1785-C1796, 2001. PMID: 11698236 (2001)
  • Long W, Zhang L, Longo LD. Cerebral artery sarcoplasmic reticulum Ca2+ stores and contractility: changes with development. Am J Physiol 279: R860-R873, 2000. PMID: 10956243 (2000)
  • Xiao Y-H, He J, Gilbert RD, Zhang L. Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathway. J Pharmacol Exp Ther 292: 8-14, 2000. PMID: 10604926 (2000)
  • Bird IM, Sullivan JA, Di T, Cale JM, Zhang L, Zheng J, Magness RR. Pregnancy-dependent changes in cell signaling underlie changes in differential control of vasodilator production in UAEC.  Endocrinology 141: 1107-1117, 2000. PMID: 10698187 (2000)
  • He J, Xiao Y-H, Zhang L. Cocaine induces apoptosis in human coronary artery endothelial cells through a calcium-dependent pathway. J Cardiovas Pharmacol 35: 572-580, 2000. PMID: 10774788 (2000)
  • Mbaku EN, Zhang L, Duckles SP, Buchholz J. Nitric oxide synthase-containing nerves facilitate adrenergic transmitter release in sheep middle cerebral arteries. J Pharmacol Exp Ther 293: 397-402, 2000. PMID: 10773008 (2000)
  • Garcia F, Stiffel V, Pearce WJ, Zhang L, Gilbert R. Ca2+ sensitivity of fetal coronary arteries exposed to long-term, high altitude hypoxia. J Soc Gynecol Invest 7: 161-166, 2000. PMID: 10865183 (2000)
  • Xiao D-L, Ducsay CA, Zhang L. Chronic hypoxia and developmental regulation of cytochrome c expression in rats. J Soc Gynecol Invest 7: 279-283, 2000. PMID: 11035279 (2000)
  • Longo LD, Zhao Y, Long W, Miguel C, Windemuth RS, Cantwell AM, Nanyonga AT, Saito T, Zhang L. Dual role of protein kinase C in modulating NE-mediated pharmacomechanical coupling in fetal and adult cerebral arteries. Am J Physiol 279: R1419-R1429, 2000. PMID: 11004012 (2000)
  • Angeles D, Williams J, Zhang L, Pearce WJ. Acute hypoxia modulates 5HT receptor density and agonist affinity in fetal and adult ovine carotid arteries. Am J Physiol 279: H502-H510, 2000. PMID: 10924047 (2000)
  • Yang S, Bae L, Zhang L. Estrogen increases eNOS and NOx release in human coronary artery endothelium. J Cardiovas Pharmacol 36: 242-247, 2000. PMID: 10942167 (2000)
  • He J, Xiao Y, Casiano C, Zhang L. Role of mitochondrial cytochrome c in cocaine-induced apoptosis in coronary artery endothelial cells. J Pharmacol Exp Ther 295: 896-903, 2000. PMID: 11082422 (2000)
  • Long W, Zhang L, Longo LD. Cerebral artery KATP- and KCa-channel activity and contractility: changes with development. Am J Physiol 279: R2004-R2014, 2000. PMID: 11080063 (2000)
  • Zhang L, Xiao Y, He J. Cocaine and apoptosis in myocardial cells. Anat Rec 257: 208-216, 1999. PMID: 10620750 (1999)
  • Long W, Zhao J, Zhang L, Longo LD. Role of Ca2+ channels in NE-induced increase in [Ca2+]i and tension in fetal and adult cerebral arteries.  Am J Physiol 277: R286-R294, 1999. PMID: 10409284 (1999)
  • Xiao D-L, Liu Y, Pearce WJ, Zhang L. Endothelial Nitric Oxide Release in Isolated Perfused Ovine Uterine Arteries: Effect of Pregnancy.  Eur J Pharmacol 367: 223-230, 1999. PMID: 10078996 (1999)
  • Hu X-Q, Yang S, Pearce WJ, Longo LD, Zhang L. Effect of chronic hypoxia on a1-adrenoceptor-mediated inositol 1,4,5-trisphosphate signaling in ovine uterine artery. J Pharmacol Exp Ther 288: 977-983, 1999. PMID: 10027834 (1999)
  • Zhang L. Inositol 1,4,5-trisphosphate mass assay.  In “Methods in Molecular Biology: Phospholipid Signaling Protocols”, Chapter 6, pp77-87, Humana Press, 1998. PMID: 10427552 (1998)
  • Zhang L, Hu X-Q, Longo LD. Effect of Chronic Hypoxia on Adrenoceptor Responses of Ovine Foetal Umbilical Vessels. Br J Pharmacol 125: 136-142, 1998. PMCID: PMC1565586 (1998)
  • Zhang L, Buxton ILO. Measurement of phosphoinositols and phosphoinositides using radio-high-performance liquid chromatography.  In “Methods in Molecular Biology: Phospholipid Signaling Protocols”, Chapter 4, pp47-63, Humana Press, 1998. PMID: 10427550 (1998)
  • Zhang L. Adaptation of pharmacomechanical coupling of vascular smooth muscle to chronic hypoxia.  Comp Biochem Physiol 119A: 661-667, 1998. PMID: 9683404 (1998)
  • Zhang L, Xiao D-L. Effects of chronic hypoxia on Ca++ mobilization and Ca++ sensitivity of myofilaments in the uterine artery. Am J Physiol 274: H132-H138, 1998. PMID: 9458861 (1998)
  • Akopov SE, Zhang L, Pearce WJ. Developmental changes in myofilament calcium sensitivity in rabbit cranial arteries. Biol Neonate 74: 60-71, 1998. PMID: 9657670 (1998)
  • Zhang L, Xiao D-L, Bouslough DB. Long-term high-altitude hypoxia increases plasma nitrate levels in pregnant ewes and their fetuses.  Am J Obstet Gynecol 179: 1594-1598, 1998. PMID: 9855603 (1998)
  • Zhang L, Hu X-Q. Endothelium-dependent potentiation by cocaine of serotonin-induced contractions in sheep fetal umbilical artery. J Soc Gynecol Invest 5: 72-74, 1998. PMID: 9509384 (1998)
  • Akopov SE, Zhang L, Pearce WJ. Maturation alters the contractile role of calcium in ovine basilar arteries.  Pediatr Res 44: 154-160, 1998. PMID: 9702907 (1998)
  • Akopov SE, Zhang L, Pearce WJ. Regulation of Ca2+ sensitization by protein kinase C and Rho proteins in ovine cerebral arteries: effects of artery size and age. Am J Physiol 275: H930-H939, 1998. PMID: 9724297 (1998)
  • Rhee JW, Zhang L, Duscay CA: Functional determination of oxytocin affinity in near-term pregnant rat myometrium: effect of chronic hypoxia.  Eur J Pharmacol 356: 9-14, 1998. PMID: 9761418 (1998)
  • Teng GQ, Williams J, Zhang L, Purdy R, Pearce WJ. Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.  Am J Physiol 275: R742-R753, 1998. PMID: 9728071 (1998)
  • Rhee JW, Zhang L, Duscay CA. Suppression of myometrial contractile responses to oxytocin following different durations of chronic hypoxia in the near-term pregnant rat. Am J Obstet Gynocol 177: 639-644, 1997. PMID: 9322636 (1997)
  • Zhou L, Zhao Y, Nijland R, Zhang L, Longo LD. Ins(1,4,5)P3 Receptors in Cerebral Arteries: Changes With Development and High-Altitude Hypoxia. Am J Physiol 272: R1954-R1959, 1997. PMID: 9227613 (1997)
  • Akopov SE, Zhang L, Pearce WJ. Mechanisms of platelet-induced angiospastic disorders: potentiation of calcium sensitivity. Can J Physiol Pharmacol 75: 849-852, 1997. PMID: 9315353 (1997)
  • Akopov SE, Zhang L, Pearce WJ. Physiological variations of ovine cerebrovascular calcium sensitivity: role of G-proteins.  Am J Physiol 272: H2271-H2281, 1997.  PMID: 9176295 (1997)
  • Hu X-Q, Zhang L. Chronic hypoxia suppresses pharmacomechanical coupling of the uterine artery in near-term pregnant sheep.  J Physiol (Lond.) 499: 551-559, 1997.  PMCID: PMC1159326 (1997)
  • Ueno N, Zhao Y, Zhang L, Longo LD. High altitude, hypoxic-induced changes in a1-adrenergic receptors and Ins(1,4,5)P3 responses in fetal and adult cerebral arteries. Am J Physiol 272: R669-R674, 1997. PMID: 9124493 (1997)
  • Zhang L. Muscarinic receptors in developing rat colon.  Eur J Pharmacol 304: 211-219, 1996. PMID: 8813604 (1996)
  • Longo LD, Ueno N, Zhao Y, Zhang L, Pearce WJ. Correlation of norepinephrine-induced contraction, α1-adrenergic receptors, and inositol 1,4,5-trisphosphate responses in ovine cerebral arteries. Am J Physiol 270: H915-H923, 1996. PMID: 8780186 (1996)
  • Hu X-Q, Longo LD, Gilbert RD, Zhang L. Effects of long-term high altitude hypoxemia on α1-adrenergic receptors in the ovine uterine artery: functional and binding studies. Am J Physiol 270: H1001-H1007, 1996. PMID: 8780196 (1996)
  • Longo LD, Ueno N, Zhao Y, Pearce WJ, Zhang L. Developmental changes in a1-adrenergic receptors, IP3 responses, and NE-induced contraction in cerebral arteries. Am J Physiol 271: H2313-H2319, 1996. PMID: 8997288 (1996)
  • Akopov SE, Zhang L, Pearce WJ. Intracranial-extracranial differences in the Ca2+ sensitivity of rabbit arteries. Soc Exp Biol Med 214: 76-82, 1996. PMID: 9012364 (1996)
  • Zhang L, Bradley ME, Buxton ILO. Inositol polyphosphate binding sites and their likely role in calcium regulation in smooth muscle. Int J Biochem Cell Biol 27: 1231-1248, 1995. PMID: 8581820 (1995)
  • Zhang L, Hu X-Q. Serotonin stimulates rapid formation of inositol 1,4,5-trisphosphate in ovine uterine artery: Correlation with contractile state.  J Pharmacol Exp Ther 275: 576-583, 1995. PMID: 7473141 (1995)
  • Zhang L, Dyer DC, Fiscus RR, Grujic Z, Wang X. 5-Hydroxytryptamine induces endothelium-independent relaxation of ovine pulmonary vein: Role of cAMP. Eur J Pharmacol 280: 335-337, 1995. PMID: 8566103 (1995)
  • Zhang L, Chang JHS. Development-related changes in colon muscarinic receptors. Proc West Pharmacol So. 38: 107-110, 1995. PMID: 7480000 (1995)
  • Zhang L, Pearce WJ, Longo LD. Noradrenaline-mediated contractions of ovine uterine artery: Role of inositol 1,4,5-trisphosphate. Eur J Pharmacol (Mol Pharmacol Section) 289: 375-382, 1995. PMID: 7621912 (1995)
  • Khoyi MA, Dalziel HH, Bjur RA, Gerthoffer WT, Zhang L, Buxton ILO, Westfall DP. [Ca2+]i-sensitive, IP3-independent Ca2+ Influx in Smooth Muscle of Rat Vas Deferens Revealed by Procaine . Br J Pharmacol 110: 1353-1358, 1993. PMCID: PMC2175887 (1993)
  • Zhang L, Bradley ME, Khoyi M, Westfall DP, Buxton ILO. Characterization of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate binding sites in canine colonic circular smooth muscle. Br J Pharmacol 109: 905-912, 1993.  PMCID: PMC2175757 (1993)
  • Smith TK, Ward SW, Zhang L, Buxton ILO, Gerthoffer WT, Sanders KM, Keef KD. ß-Adrenergic inhibition of electrical and mechanical action in canine colon: Role of cyclic AMP.  Am J Physiol 264: G708-G717, 1993. PMID: 8386465 (1993)
  • Zhang L, Dyer DC. Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in the ovine uterine artery of late pregnancy. Eur J Pharmacol 230: 115-117, 1993. PMID: 8428600 (1993)
  • Zhang L, Buxton ILO. Protein kinase regulation of muscarinic receptor signalling in colonic smooth muscle. Br J Pharmacol 108: 613-621, 1993. PMCID: PMC1908018 (1993)
  • Ozaki H, Zhang L, Buxton ILO, Sanders KM, Publicover NG. Phosphatydyl inositol-turnover: a negative feed-back mechanism for excitation-contraction coupling in gastric smooth muscle. Am J Physiol 263: C1160-C1171, 1992. PMID: 1476162 (1992)
  • Zhang L, Keef KD, Bradley ME, Buxton ILO. The action of α2A-adrenergic receptors in the circular smooth muscle of canine proximal colon.  Am J Physiol 262: G517-G524, 1992. PMID: 1312795 (1992)
  • Zhang L, Dyer DC. 5-HT2 Receptor stimulated calcium influx in ovine uterine artery in late pregnancy. Arch Int Pharmacodyn Ther 310: 46-55, 1991. PMID: 1772330 (1991)
  • Zhang L, Dyer DC, Hembrough FB, Isla M. Effects of R(-)2,5-dimethoxy-4-methyl-amphetamine (DOM) on uterine and umbilical blood flow in conscious pregnant sheep. Eur J Pharmacol 199: 179-184, 1991. PMID: 1954976 (1991)
  • Zhang L, Dyer DC. Characterization of α-adrenoceptor mediating contraction in isolated ovine umbilical vein.  Eur J Pharmacol 197: 63-67, 1991. PMID: 1680054 (1991)
  • Zhang L, Horowitz B, Buxton ILO. Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes. Mol Pharmacol 40: 943-951, 1991. PMID: 1758444 (1991)
  • Zhang L, Buxton ILO. Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways coupled to the muscarinic receptors.  Mol Pharmacol 40: 952-959, 1991. PMID: 1661840 (1991)
  • Zhang L, Dyer DC. 5-HT receptor mediated vasoconstriction in the ovine fetal umbilical vein. Eur J Pharmacol 184: 281-293, 1990. PMID: 2213559 (1990)
  • Zhang L, Dyer DC. Characterization of serotonergic receptors mediating contraction of ovine umbilical artery. J Pharmacol Exp Ther 255: 233-239, 1990.  PMID: 2213559 (1990)
  • Dyer DC, Zhang L, Hembrough FB, Isla M.  Hemodynamic responses to cocaine in the pregnant ewe and fetus: Effects of prazosin. Eur J Pharmacol 183: 819-820, 1990. (1990)
  • Zhang L, Dyer DC. Characterization of 5-hydroxytryptamine receptors on isolated ovine uterine artery in late pregnancy. J Pharmacol Exp Ther 253: 1236-1244, 1990. PMID: 2359025 (1990)