Research Projects & Grants

• Therapeutic radiation treatment in the middle cerebral artery occlusion (MCAO) animal model, Role: PI, (04/2010 - 04/2011) Status: Completed
• MRI assessment of therapeutic radiation treatment of intracerebral hemorrhage, Role: PI, (05/2010 - 05/2011) Status: Completed

College/University

• Cognitive Deficits After Experimental Febrile Seizures: Neurobiology & Biomarkers, Role: Principal Investigator, Dartmouth College, (09/2011 - 04/2013) Status: Closed
• Mechanism of Action of Omega-3 Fatty Acids in Brain Injury, Role: Principal Investigator, Louisiana State University, (09/2009 - 09/2011) Status: Closed
• Febrile Seizure Model - Neuronal Injury and Mechanisms, Role: Principal Investigator, University of California, Irvine, (11/2009 - 08/2010) Status: Closed
• Inflammation in the Brain after Particulate Irradiation Predisposes the Hippocampus to a Heightened Vulnerability after a Secondary Insult, Role: Principal Investigator, University of California, San Francisco, (08/2005 - 05/2010) Status: Closed
• The Contribution of CD74 to Acquired Epilepsy, Role: Principal Investigator, Texas A&M University, (09/2016 - 11/2017) Status: Closed
• Epileptogenesis following FSE Mechanisms Biomarkers Prevention, Role: Principal Investigator, University of California, Irvine, (09/2014 - 07/2017) Status: Closed
• Cognitive Deficits after Experimental Febrile Seizures: Neurobiology & Biomarkers, Role: Principal Investigator, University of Vermont, (07/2013 - 06/2015) Status: Closed
• Prevention of Temporal Lobe Epilepsy, Role: Principal Investigator, University of California, Irvine, (09/2012 - 06/2015) Status: Closed
• Fragmented Early Life Experiences and Cognitive and Emotional Vulnerabilities, Role: Principal Investigator, University of California, Irvine, (06/2013 - 04/2017) Status: Closed
• MRI of Cortical Contusion Injury Induced Neurotrauma: Diffusion Weighted Imaging and Oxygen Extraction Imaging for Assessment of the Evolution of Injury, Role: Principal Investigator, University of California, (02/2004 - 12/2006) Status: Closed

Federal

• Development of imaging techniques for computed tomography (CT)/11.7 magnetic resonance imaging (MRI) of rodents, Role: PI, National Institutes of Health/DHHS, (07/2011 - 07/2012) Status: Completed
• Inflammation in the brain after particulate irradiation predisposes the hippocampus to a heightened vulnerability after a secondary insult-2, Role: PI, National Aeronautics & Space Administration, (05/2010 - 05/2011) Status: Completed
• The effects of charged particle radiation on neurodegenerative disease progression - II, Role: PI, National Aeronautics & Space Administration, (02/2009 - 02/2010) Status: Completed
• Charged particle alterations of the functional output of the brain as a function of dose, time, and LET - II, Role: PI, National Aeronautics & Space Administration, (03/2009 - 03/2010) Status: Completed
• The bioluminescence detection of gliosis in the CNS of mice following exposure to high-charge, high-energy (HZE) radiation, Role: PI, National Aeronautics & Space Administration, (02/2008 - 02/2009) Status: Completed
• The effects of charged particle radiation on the CNS response to an immunological stressor, Role: PI, National Aeronautics & Space Administration, (03/2006 - 03/2007) Status: Completed
• Assessment of intracerebral hemorrhage using magnetic resonance imaging (MRI), Role: PI, National Aeronautics & Space Administration, (03/2006 - 11/2006) Status: Completed
• Quantitative assessment of a brain tumor by MRI/MRS/CT following proton irradiation, Role: PI, National Aeronautics & Space Administration, (06/2005 - 06/2006) Status: Completed
• Central Nervous System NSCOR Aim 3: radiation adaptive effects on mouse brain, Role: Investigator, National Aeronautics & Space Administration, (03/2014 - 03/2015) Status: Completed
• Evaluation of cannula-based local and systemic administrations for cancer gene therapies in experimental animal models, Role: Investigator, National Medical Technology Testbed, Inc., (12/2003 - 12/2004) Status: Completed
• Iron metabolism alterations in Alzheimer's disease, Role: Investigator, National Institutes of Health/DHHS, Status: Completed
• Differential cognitive, behavioral, and biological effects of proton and Fe irradiation of the rat brain, Role: PI, National Aeronautics & Space Administration, Status: Completed
• Responses of mouse brain to proton irradiation: behavioral and electrophysiological analysis, Role: Investigator, National Aeronautics & Space Administration, (04/2012 - 04/2013) Status: Completed
• Cooperative Research in Proton Space Radiation, Role: Director, MR Imaging, National Aeronautics & Space Administration, (01/2010 - 12/2010) Status: Closed
• (NSCOR): Carcinogenesis and Central Nervous System Risks from Space Radiation, Role: Co-Investigator, National Aeronautics & Space Administration, (01/2010 - 06/2016) Status: Closed
• AQP4 and JNK Inhibition Together Reduce Edema and Excitotoxic Injury in jTBI, Role: Co-I, National Institute of Child Health and Human Development/NIH/DHHS, (07/2009 - 06/2015) Status: Closed
• Automated MRI qualification of therapeutic neuronal stem cell activity, Role: Co-investigator, National Medical Technology Testbed, Inc., (02/2009 - 03/2011) Status: Closed
• Gene therapy prevents edema formation in the brain after juvenile traumatic brain injury, Role: Principal Investigator, National Medical Technology Testbed, Inc., (02/2009 - 03/2011) Status: Closed
• Neuroprotective strategies after repetitive mild traumatic brain injury, Role: Principal Investigator, Department of Defense, (06/2009 - 06/2011) Status: Closed
• Neonatal Brain Ischemia: Neuroimaging as a Basis For Rational Stem Cell Therapy, Role: Co-investigator, National Institute of Neurological Disorders and Stroke/NIH/DHHS, (03/2009 - 02/2014) Status: Closed
• Cooperative research in proton space radiation, Role: Co-PD/PI, National Aeronautics & Space Administration, (10/2008 - 12/2009) Status: Closed
• Cooperative research in proton space radiation, Role: Imaging Director, National Aeronautics & Space Administration, (10/2006 - 09/2008) Status: Closed
• Neurovascular Protection for Subarachnoid Hemorrhage, Role: Co-Investigator, National Institute of Neurological Disorders and Stroke/NIH/DHHS, (06/2006 - 05/2011) Status: Closed
• Cooperative research in proton space radiation, Role: PD/PI, National Aeronautics & Space Administration, (10/2005 - 09/2009) Status: Closed
• Iron Metabolism alterations in Alzheimer's disease, Role: Research Associate, National Institutes of Health/DHHS, (07/2005 - 06/2006) Status: Closed
• Iron metabolism alterations in Alzheimer's Disease, National Institute on Aging/NIH/DHHS, (07/2004 - 06/2005) Status: Closed
• Progressive Alterations of Central Nervous System Structure and Function are Caused by Charged Particle Radiation, Role: Co-PD/PI, National Aeronautics & Space Administration, (01/2004 - 12/2009) Status: Closed
• Non-invasive assessment of neuropathology following CNS radiation exposure, National Aeronautics & Space Administration, (05/2004 - 06/2008) Status: Closed
• Cooperative research in proton space radiation, Role: Key, National Aeronautics & Space Administration, (01/2002 - 04/2006) Status: Closed
• LLU-NIH Initiative for Maximizing Student Development, Role: Other Significant Contributor, National Institute of General Medical Sciences/NIH/DHHS, (01/2018 - 12/2023) Status: Awarded
• Center for Brain Hemorrhage Research, Role: PD/PI, National Institutes of Health/DHHS, (01/2014 - 12/2019) Status: Closed
• Harness Germinal Matrix Hemorrhage, Role: Co-Investigator, National Institutes of Health/DHHS, (09/2012 - 06/2017) Status: Closed
• Cooperative Research in Proton Space Radiation, Role: Director, MR Imaging, National Aeronautics & Space Administration, (01/2011 - 06/2013) Status: Closed

For Profit Organization

• Effects of cribriform plate occlusion in ferrets., Role: PI, Leucadia Therapeutics, LLC, (08/2017 - 08/2019) Status: Completed
• Novel compounds protect hippocampal neurons from ischemia-induced neuronal damage, Role: PI, Prescient NeuroPharm Inc., (12/1899) Status: Completed

Internal

• Neonatal brain ischemia: neuroimaging as a basis for rational stem cell therapy, Role: Investigator, LLU Dept. of Pediatrics, (11/2008 - 10/2009) Status: Completed
• Role of aquaporin in neonatal stroke, Role: Investigator, LLU Dept. of Pediatrics, (11/2008 - 10/2009) Status: Completed
• Hemorrhage in acute infarcts: incidence in spontaneous hypertensive rats and comparison of detectability in MRI and CT examination, Role: Investigator, LLU Dept. of Radiology, (03/2006 - 03/2007) Status: Completed
• Magnetic resonance imaging and spectroscopy in an animal model of temporal lobe epilepsy, Role: PI, LLU Radiobiology Program, (08/2005 - 08/2006) Status: Completed
• Exploring the neuroprotective effects of a polyphenol-enriched diet, Role: Investigator, LLU Behavioral Medical Center, (07/2015 - 07/2016) Status: Completed
• Hyperbaric oxygen treatment improves outcomes following repetitive mild juvenile traumatic brain injury, Role: Investigator, LLU School of Science and Technology, (01/2013 - 01/2014) Status: Completed
• Pediatric traumatic brain injury dysregulates the molecular cues of white matter, Role: Principal Investigator, LLU School of Medicine, (06/2014 - 12/2016) Status: Closed

Non-Profit Organization

• Characterizing axonal damage from transient retinal ischemia in mice using diffusion tensor imaging, Role: Investigator, National Multiple Sclerosis Society, (07/2010 - 07/2011) Status: Completed
• Transcriptional mechanisms underlying hypoxia-induced white matter injury during early postnatal development, Role: Investigator, Pediatric Epilepsy Research Foundation, (10/2014 - 10/2015) Status: Completed
• Transcritptional Mechanisms Underlying Hypoxia-induced White Matter Injury During Early Postnatal Development, Role: Mentor, Pediatric Epilepsy Research Foundation, (11/2012 - 10/2015) Status: Closed