Publications

Scholarly Journals--Published

• Angeles DM, Boskovic DS, Tan JC, Shih W, Hoch E, Forde D, Phillips RM, Hopper A, Deming DD, Goldstein M Truong G, Febre A, Pegis P, Lavery A, Kadri M, Banerji A, Mousselli I, Farha V, Fayard E. J Perinatol 2020. Oral dextrose reduced procedural pain withou altering cellular ATP metabolism in preterm neonates: a prospective randomized trial (02/2020)
• Oxidative Stress Biomarker Decreased in Preterm Neonates Treated With Kangaroo Mother CareDorothy Forde, PhD1,2 , Douglas D. Deming, MD3 , John C. Tan, PhD4 , Raylene M. Phillips, MD3 , Eileen K. Fry-Bowers, PhD1 , Mary K. Barger, PhD1 , Khaled Bahjri, PhD5 , Danilyn M. Angeles, PhD3,6, and Danilo S. Boskovic, PhDBiological Research for Nursing: 2020 Objective: Due to physiological and metabolic immaturity, prematurely born infants are at increased risk because of maternal separation in many neonatal intensive care units (NICUs). The stress induced from maternal–infant separation can lead to welldocumented short-term physiologic instability and potentially lifelong neurological, sociological, or psychological sequelae. Based on previous studies of kangaroo mother care (KMC) that demonstrated improvement in physiologic parameters, we examined the impact of KMC on physiologic measures of stress (abdominal temperature, heart rate, oxygen saturation, perfusion index, near-infrared spectrometry), oxidative stress, and energy utilization/conservation in preterm infants. Methods: In this randomized, stratified study of premature neonates, we compared the effects on urinary concentrations of biomarkers of energy utilization and oxidative stress of 1 hr of KMC versus incubator care on Day 3 of life in intervention-group babies (n ¼ 26) and control-group babies (n ¼ 25), respectively. On Day 4, both groups received 1 hr of KMC. Urinary samples were collected 3 hr before and 3 hr after intervention/incubator care on both days. Energy utilization was assessed by measures of adenosine triphosphate (ATP) degradation (i.e., hypoxanthine, xanthine, and uric acid). Oxidative stress was assessed using urinary allantoin. Mixed-models analysis was used to assess differences in purine/allantoin. Results: Mean allantoin levels over Days 3 and 4 were significantly lower in the KMC group than in the control group (p ¼ .026). Conclusions: Results provide preliminary evidence that KMC reduces neonatal oxidative stress processes and that urinary allantoin could serve as an effective noninvasive marker for future studies. (01/2020)
• Liu Y, Abongwa C, Ashwal S, Deming DD, Winter TW. JAMA Netw Open 2019. Referral for Ophthalmology Evaluation and Visual Sequelae in Children with Primary Brain Tumors (10/2019)
• Hutson S, Baerg J, Deming D, St Peter S D, Hopper A, & Goff D A. (2017). High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele. Neonatology, 112(3), 281-286. BACKGROUND: Omphalocele is one of the most common abdominal wall defects. Many newborn infants born with omphalocele present with significant respiratory distress at birth, requiring mechanical ventilatory support, and have clinical evidence of pulmonary hypertension. Little information exists on the prevalence of and risk factors associated with pulmonary hypertension in this cohort of infants. OBJECTIVES: To describe the prevalence of and risk factors associated with pulmonary hypertension among infants with omphalocele. METHODS: This is a multicenter retrospective chart review of demographic data and clinical characteristics of infants with omphalocele admitted to the neonatal intensive care units of Loma Linda University Children's Hospital and Children's Mercy Hospital between 1994 and 2011. Echocardiogram images were reviewed for pulmonary hypertension, and statistical analyses were performed to identify risk factors associated with the presence of pulmonary hypertension. RESULTS: Pulmonary hypertension was diagnosed in 32/56 (57%) infants with omphalocele. Compared to infants without pulmonary hypertension, infants with pulmonary hypertension were more likely to have a liver-containing defect (16/32 [50%] vs. 5/24 [21%], p = 0.03), require intubation at birth (18/32 [56%] vs. 6/24 [17%], p = 0.03), and die during initial hospitalization (12/32 [38%] vs. 2/24 [8%], p = 0.01). CONCLUSION: The majority of infants with omphalocele have evidence of pulmonary hypertension which is associated with increased mortality. Echocardiograms to screen for pulmonary hypertension should be obtained at >/=2 days of life in infants with omphalocele, especially in those with liver within the omphalocele sac and/or in those infants who require intubation at birth to screen for pulmonary hypertension. (07/2017) (link)
• High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele Hutson, S. Baerg, J. Deming, D. St Peter, S. D. Hopper, A. Goff, D. A.Neonatology 112(3);281-286Abstract: BACKGROUND: Omphalocele is one of the most common abdominal wall defects. Many newborn infants born with omphalocele present with significant respiratory distress at birth, requiring mechanical ventilatory support, and have clinical evidence of pulmonary hypertension. Little information exists on the prevalence of and risk factors associated with pulmonary hypertension in this cohort of infants. OBJECTIVES: To describe the prevalence of and risk factors associated with pulmonary hypertension among infants with omphalocele. METHODS: This is a multicenter retrospective chart review of demographic data and clinical characteristics of infants with omphalocele admitted to the neonatal intensive care units of Loma Linda University Children's Hospital and Children's Mercy Hospital between 1994 and 2011. Echocardiogram images were reviewed for pulmonary hypertension, and statistical analyses were performed to identify risk factors associated with the presence of pulmonary hypertension. RESULTS: Pulmonary hypertension was diagnosed in 32/56 (57%) infants with omphalocele. Compared to infants without pulmonary hypertension, infants with pulmonary hypertension were more likely to have a liver-containing defect (16/32 [50%] vs. 5/24 [21%], p = 0.03), require intubation at birth (18/32 [56%] vs. 6/24 [17%], p = 0.03), and die during initial hospitalization (12/32 [38%] vs. 2/24 [8%], p = 0.01). CONCLUSION: The majority of infants with omphalocele have evidence of pulmonary hypertension which is associated with increased mortality. Echocardiograms to screen for pulmonary hypertension should be obtained at >/=2 days of life in infants with omphalocele, especially in those with liver within the omphalocele sac and/or in those infants who require intubation at birth to screen for pulmonary hypertension. (03/2017) (link)
• Changes in plasma and urinary nitrite after birth in premature infants at risk for necrotizing enterocolitis Pun, P. Jones, J. Wolfe, C. Deming, D. D. Power, G. G. Blood, A. B.Pediatr Res 79(3);432-7Abstract: BACKGROUND: Plasma nitrite serves as a reservoir of nitric oxide (NO) bioactivity. Because nitrite ingestion is markedly lower in newborns than adults, we hypothesized plasma nitrite levels would be lower in newborns than in adults, and that infants diagnosed with necrotizing enterocolitis (NEC), a disease characterized by ischemia and bacterial invasion of intestinal walls, would have lower levels of circulating nitrite in the days prior to diagnosis. METHODS: Single blood and urine samples were collected from 9 term infants and 12 adults, 72 preterm infants every 5 d for 3 wk, and from 13 lambs before and after cord occlusion. RESULTS: Nitrite fell 50% relative to cord levels in the first day after birth; and within 15 min after cord occlusion in lambs. Urinary nitrite was higher in infants than adults. Plasma and urinary nitrite levels in infants who developed NEC were similar to those of preterm control infants on days 1 and 5, but significantly elevated at 15 and 20 d after birth. CONCLUSION: Plasma nitrite falls dramatically at birth while newborn urinary nitrite levels are significantly greater than adults. Acute NEC is associated with elevated plasma and urinary nitrite levels. (03/2016) (link)
• Copeland Hannah, Razzouk Anees, Chinnock Richard, Deming Douglas, Hasaniya Nahidh, & Bailey Leonard. (2014). Pediatric Recipient Survival Beyond 15 Post-Heart Transplant Years: A Single-Center Experience. Annals of Thoracic Surgery, 98(6), 2145-2151. Background. We evaluated late survival among pediatric heart transplant patients who have lived more than 15 years. Methods. This is a retrospective chart review of the pediatric patients who underwent heart transplantation (HTx) between 1985 and 1998. Multivariate and univariate analyses were examined. Results. There were 183 recipients, of whom 151 are currently alive. Age at HTx ranged from 0 days to 17.48 years (median 56 days). Pretransplant diagnoses included congenital heart disease 142 (77.6%), cardiomyopathy 38 (20.8%), and tumor 3 (1.6%). Pretransplant renal dysfunction was present in 58 patients (31.7%). Perioperative peritoneal dialysis was instituted in 15 patients, all recovered. During the follow-up period (median 20.2 years), 17 (9.3%) have had renal transplants, and 2 require hemodialysis. There were 32 deaths from the following: cardiac allograft vasculopathy (CAV); 11 (34.3%); posttransplant lymphoproliferative disease 6 (18.8%); acute rejection 4 (12.5%); sepsis 2 (6.3%); multiorgan failure 1 (3.1%); and unknown 8 (25%). Immunosuppressive therapy for the living patients consists of monotherapy 25 (17.7%), dual therapy 87 (61.7%), triple therapy 24 (17%), quadruple therapy 5 (3.5%), and 10 unknown. Cardiac re-Tx was required for CAV in 30 patients and for graft failure in 6 patients. Four patients required a third transplant for CAV. For those who survived more than 15 years after HTx, actuarial survival to 20 years and 25 years is 82% and 78%, respectively. Conclusions. Pediatric HTx provides acceptable longterm survival. Cardiac re-Tx and renal transplantation offer reasonable palliation for recipients who develop CAV and renal dysfunction. (C) 2014 by The Society of Thoracic Surgeons (12/2014) (link)
• Angeles Danilyn M, Boskovic Danilo S, & Deming Douglas. (2014). Sucrose and oxidants Reply. Journal of Pediatrics, 164(1), 220-221. (01/2014) (link)
• Czynski A J, Terry M H, Deming D D, Power G G, Buchholz J N, & Blood A B. (2013). Cerebral Autoregulation Is Minimally Influenced by the Superior Cervical Ganglion in Two- Week-Old Lambs, and Absent in Preterm Lambs Immediately Following Delivery. PLoS One, 8(12), 8. Cerebral vessels in the premature newborn brain are well supplied with adrenergic nerves, stemming from the superior cervical ganglia (SCG), but their role in regulation of blood flow remains uncertain. To test this function twelve premature or two-week-old lambs were instrumented with laser Doppler flow probes in the parietal cortices to measure changes in blood flow during changes in systemic blood pressure and electrical stimulation of the SCG. In lambs delivered prematurely at,129 days gestation cerebral perfusion and driving pressure demonstrated a direct linear relationship throughout the physiologic range, indicating lack of autoregulation. In contrast, in lambs two-weeks of age, surgical removal of one SCG resulted in ipsilateral loss of autoregulation during pronounced hypertension. Electrical stimulation of one SCG elicited unilateral increases in cerebral resistance to blood flow in both pre-term and two-week-old lambs, indicating functioning neural pathways in the instrumented, anesthetized lambs. We conclude cerebral autoregulation is non-functional in preterm lambs following cesarean delivery. Adrenergic control of cerebral vascular resistance becomes effective in newborn lambs within two-weeks after birth but SCG-dependent autoregulation is essential only during pronounced hypertension, well above the normal range of blood pressure. (12/2013) (link)
• Asmerom Y, Slater L, Boskovic D S, Bahjri K, Holden M S, . . . Angeles D M. (2013). Oral Sucrose for Heel Lance Increases Adenosine Triphosphate Use and Oxidative Stress in Preterm Neonates. Journal of Pediatrics, 163(1), 29-U406. Objective To examine the effects of sucrose on pain and biochemical markers of adenosine triphosphate (ATP) degradation and oxidative stress in preterm neonates experiencing a clinically required heel lance. Study design Preterm neonates that met study criteria (n = 131) were randomized into 3 groups: (1) control; (2) heel lance treated with placebo and non-nutritive sucking; and (3) heel lance treated with sucrose and non-nutritive sucking. Plasma markers of ATP degradation (hypoxanthine, xanthine, and uric acid) and oxidative stress (allantoin) were measured before and after the heel lance. Pain was measured with the Premature Infant Pain Profile. Data were analyzed by the use of repeated-measures ANOVA and Spearman rho. Results We found significant increases in plasma hypoxanthine and uric acid over time in neonates who received sucrose. We also found a significant negative correlation between pain scores and plasma allantoin concentration in a subgroup of neonates who received sucrose. Conclusion A single dose of oral sucrose, given before heel lance, significantly increased ATP use and oxidative stress in premature neonates. Because neonates are given multiple doses of sucrose per day, randomized trials are needed to examine the effects of repeated sucrose administration on ATP degradation, oxidative stress, and cell injury. (07/2013) (link)
• Slater L, Asmerom Y, Boskovic D S, Bahjri K, Plank M S, . . . Angeles D M. (2012). Procedural Pain and Oxidative Stress in Premature Neonates. Journal of Pain, 13(6), 590-597. Preterm neonates exposed to painful procedures in the neonatal intensive care unit exhibit increased pain scores and alterations in oxygenation and heart rate. It is unclear whether these physiological responses increase the risk of oxidative stress. Using a prospective study design, we examined the relationship between a tissue-damaging procedure (TDP; tape removal during discontinuation of an indwelling central arterial or venous catheter) and oxidative stress in 80 preterm neonates. Oxidative stress was quantified by measuring uric acid (UA) and malondialdehyde (MDA) concentration in plasma before and after neonates (n = 38) experienced a TDP compared to those not experiencing any TDP (control group, n = 42). Pain was measured before and during the TDP using the Premature Infant Pain Profile (PIPP). We found that pain scores were higher in the TOP group compared to the control group (median scores, 11 and 5, respectively; P < .001). UA significantly decreased over time in control neonates but remained stable in TDP neonates (132.76 to 123.23 mu M versus 140.50 to 138.9 mu M; P = .002). MDA levels decreased over time in control neonates but increased in TDP neonates (2.07 to 1.81 mu M versus 2.07 to 2.21 mu M, P = .01). We found significant positive correlations between PIPP scores and MDA. Our data suggest a significant relationship between procedural pain and oxidative stress in preterm neonates. Perspective: This article presents data describing a significant relationship between physiological markers of neonatal pain and oxidative stress. The method described in this paper can potentially be used to assess the direct cellular effects of procedural pain as well the effectiveness of interventions performed to decrease pain. (C) 2012 by the American Pain Society (06/2012) (link)
• Chinnock T J, Shankel T, Deming D, Cutler D, Sahney S, Fitts J, & Chinnock R E. (2011). Calcineurin inhibitor minimization using sirolimus leads to improved renal function in pediatric heart transplant recipients. Pediatric Transplantation, 15(7), 746-749. The introduction of cyclosporine revolutionized the practice of immunosuppression for solid organ transplant recipients, and has resulted in a significant increase in survival. While CNI use has been the mainstay of immunosuppressive therapy in pediatric heart transplantation, CNIs have been associated with an increased risk of nephropathy leading to significant morbidity and mortality. We evaluated the effect on renal function of a CNI minimization protocol using SRL in pediatric heart transplant patients with CNI induced renal insufficiency. An IRB approved retrospective chart review and case control study was performed. There were 20 patients identified with renal insufficiency who had been converted to SRL (target 5-8 ng/mL) and cyclosporine (target 50-75 vs. 125-150 ng/mL). Renal insufficiency was defined as isotopic (Indium 111 DTPA) GFR < 60 mL/min per 1.73 m(2) or sCr > 1 mg/dL. Outcome variables evaluated were GFR and sCr at time of conversion and at two yr post conversion. Comparison was made with case control subjects matched for age at Tx, time from Tx to conversion, and initial GFR. The median age at Tx = 81 days (S.D. +/- 26), median time of conversion after Tx = 10 yrs (s.d. +/- 0.65). Self-limited/treatable side effects included hypercholesterolemia (10), neutropenia (6), aphthous ulcer (3), edema (2), anemia (2), and tremor (1). One patient rejected in the two yr prior to conversion, and one patient had two rejection episodes following conversion. GFR at conversion for study group was 51 +/- 14 vs. 60 +/- 22 at two yr, p = 0.018. GFR at inclusion for control group was 56 +/- 20 vs. 53 +/- 21, p = 0.253. This report demonstrates that minimizing CNI exposure by addition of SRL to the immunosuppressant regimen in pediatric heart transplant recipients result in improved renal function in comparison to historically managed patients. Furthermore, immunotherapy with SRL and lower-dose CNI can effectively prevent rejection with an acceptable side-effect profile. (11/2011) (link)
• Phillips R M, Merritt T A, Goldstein M R, Deming D D, Slater L E, & Angeles D M. (2011). Prevention of postpartum smoking relapse in mothers of infants in the neonatal intensive care unit. J Perinatol, , . Objective:Approximately 40% of women who smoke tobacco quit smoking during pregnancy, yet up to 85% relapse after delivery. Those who resume smoking often do so by 2 to 8 weeks postpartum. Smoking mothers are more than twice as likely to quit breastfeeding by 10 weeks postpartum. The hospitalization of a newborn, while stressful, is an opportunity to emphasize the importance of a smoke-free environment for babies. Supporting maternal-infant bonding may reduce maternal stress and motivate mothers to remain smoke free and continue breastfeeding. The objective of this study was to reduce postpartum smoking relapse and prolong breastfeeding duration during the first 8 weeks postpartum in mothers who quit smoking just before or during pregnancy and have newborns admitted to the Neonatal Intensive Care Unit (NICU).Study Design:This study was an Institutional Review Board-approved prospective randomized clinical trial. After informed consent, mothers of newborns admitted to the NICU were randomized to a control or intervention group. Both groups received weekly encouragement to remain smoke free and routine breastfeeding support. Mothers in the intervention group were also given enhanced support for maternal-infant bonding including information about newborn behaviors, and were encouraged to frequently hold their babies skin-to-skin.Result:More mothers were smoke free (81 vs 46%, P<0.001) and breastfeeding (86 vs 21%, P<0.001) in the intervention than in the control group at 8 weeks postpartum.Conclusion:Interventions to support mother-infant bonding during a newborn's hospitalization in the NICU are associated with reduced rates of smoking relapse and prolonged duration of breastfeeding during the first 8 weeks postpartum.Journal of Perinatology advance online publication, 11 August 2011; doi:10.1038/jp.2011.106. (08/2011) (link)
• Merritt T A, Deming D D, & Boynton B R. (2009). The 'new' bronchopulmonary dysplasia: challenges and commentary. Seminars in Fetal & Neonatal Medicine, 14(6), 345-357. Lung development is orchestrated by highly integrated morphogenic programs of interrelated patterns of gene and protein expression. Injury to the developing lung in the canalicular and saccular phases of lung development alters subsequent alveolar and vascular development resulting in simplified alveolar structures, dysmorphic capillary configuration, variable interstitial cellularity and fibroproliferation that are characteristic of the 'new' bronchopulmonary dysplasia (BPD). Fetal and neonatal infection, abnormal stretch of the developing airways and alveoli, altered expression Of surfactant proteins (or genetically altered proteins), polymorphisms of genes encoding for vascular endothelial growth factors, and reactive oxygen species result in imparied gas exchange in the developing lung. However, the 'new' BPD represents only one form of neonatal chronic lung disease and the consistent use of both the physiologic definition and severity scale would provide greater accuracy in determining the impact of the disease currently defined by its treatment. Our present labelling of the clinical state of oxygen Supplementation and/or ventilatory support at 36 weeks' postmenstrual age and the histopathologic severity of alveolar arrest and vascular 'simplification' may not always be predictive of the degree of altered lung development and thus longer-term pulmonary function evaluations are needed to determine the impact of this disorder in specific infants. The proposed role of novel molecular therapies, and the combined effects Of Currently established therapies, as well as exogenous surfactant and inhaled nitric oxide or repetitive surfactant dosing, on the severity and incidence of new BPD hold considerable promise for reducing the long-term Pulmonary moribidity among infants delivered prematurely. (C) 2009 Elsevier Ltd. All rights reserved. (12/2009) (link)
• Deming D, Rabin C, Hopper A, Peverini R, Vyhmeister N, Nelson J. "Direct Equilibrium Dialysis Compared with Two Non-Dialysis Free T4 Methods in Premature Infants." Journal of Pediatrics . (2007): 404-408. (10/2007)
• Morkos AA, Hopper AO, Deming DD, Yellon SM, Wycliffe ND, Ashwal S, Peverini RL, Angeles, DM. "Elevated Total Peripheral Leukocyte Count May Identify Risk for Abnormal MRI Imaging and Neurologic Disability in Infants with Hypoxic-Ischemic Encephalopathy." Journal of Perinatology 27.6 (2007): 365-370. (06/2007)

Abstract

• (NON-PEER REVIEWED) Outcomes of Ligation versus Catheter Occlusion in Very Low Birthweight Infants T Rauser, A Marshall, P Agrawal, P Jung K Rawson, BM Gordon, D Deming Presented to the Western Society for Pediatric Research, January 24, 2020, Carmel, CA J Investig Med 2020;68:240 (02/2020)
• (NON-PEER REVIEWED) Visual Sequelae in Children with Primary Brain Tumors  Abstract submitted to:  47th Annual Child Neurology Society Meeting (02/2018)
• (PEER REVIEWED) Patent Ductus Arteriosus Ligation Increases Risk of Bronchopulmonary Dysplasia P Jung, E Rickards, D Deming BACKGROUND Treatment of a patent ductus arteriosus (PDA) in preterm infants remains controversial. It has been difficult to ascertain whether treatment type alters the prevalence of bronchopulmonary dysplasia (BPD).   OBJECTIVE We questioned whether the prevalence of BPD was different in preterm infants treated for PDA depending on the type of therapeutic intervention.   DESIGN/METHODS We retrospectively reviewed charts of infants admitted between January 2010 and July 2017 with birth weight ≤ 1,500 grams and echocardiographic evidence of a PDA. Interventions included indomethacin alone, surgical ligation alone, indomethacin with later ligation, and no intervention. We then evaluated the prevalence of BPD and its association to treatment type. Chi-square and multivariate logistic regression (model was built utilizing treatment type) were analyzed, (SPSS, v 22, IBM).   RESULTS There were 689 total infants that met entry criteria and 482 underwent therapy for a PDA (70%). The distribution of treatment types was: 184 (27%) received indomethacin alone, 189 (27%) underwent ligation alone, 109 (16%) received indomethacin with later ligation, and 207 (30%) received no intervention (p<0.001).   The overall prevalence of BPD was 55%. It was 53% among infants who received indomethacin alone, 76% in infants who underwent ligation alone, 65%in infants who underwent ligation after an indomethacin course, and 32% in infants who received no intervention.   The development of BPD was significantly associated with all modes of intervention when compared to no treatment. Specifically, surgical ligation alone had the highest odds of BPD (OR 6.836, p<0.001) followed by the ligation after indomethacin group.   CONCLUSIONS In our study, the prevalence of BPD depended upon the treatment intervention for the PDA.  It was highest in infants treated with surgical ligation alone.   While we show a high association of surgical ligation with the prevalence of BPD, our results do not support a cause and effect relationship. Further studies are required.   Table: Odds Ratios of BPD by Treatment Type Compared to No Intervention   Odds Ratio (95% CI) p Indomethacin Alone 2.382 (1.579-3.594) <0.001 Ligation Alone 6.836 (4.384-10.662) <0.001 Ligation Following Indomethacin 3.992 (2.444-6.519) <0.001 No Intervention Referent Referent (01/2018)
• Timing and indications for delivery at less than 39 weeks in neonates with complex congenital heart disease (CCHD) W Belay, S Davis, J Gates, A Hopper, D Deming, B Oshiro, D GoffPresented to the 2017 Annual Clinical and Scientific Meeting of the American College of Obesterics and Gynocologists May 6-9, 2017, San Diego, CA (05/2017)
• High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele. Neonatology Hutson S, Baerg J, Deming D, St Peter SD, Hopper A, Goff DANeonatology. 2017;112(3):281-6. (03/2017) (link)
• Comparison of two commercially available liquied human milk fortifiers for feeding tolerance in premature infants Calma E. Judkins A, Truong G, Kadri M, Deming D, Fayard E, Phillips R.Presented to the American Academy of Pediatrics National Convention and ExhibitionOctober 2016 (10/2016)
• Kuhn M A, Deming D D, Fitts J, Bailey L L, & Chinnock R E. (2012). Long-Term Outcome of Pediatric Heart Transplant Patients with Incidental Subclinical Cellular Rejection during Annual Study. Journal of Heart and Lung Transplantation, 31(4), S204-S204. (04/2012)
• Kuhn M A, Deming D D, Fitts J, Bailey L L, & Chinnock R E. (2012). Long-Term Outcome of Pediatric Heart Transplant Patients with Incidental Subclinical Cellular Rejection during Annual Study. Journal of Heart and Lung Transplantation, 31(4), S204-S204. (04/2012)
• Kuhn M A, Deming D D, Bailey L L, & Chinnock R E. (2011). THE EFFECT OF SIROLIMUS ON CARDIAC ALLOGRAFT VASCULOPATHY IN PEDIATRIC HEART TRANSPLANT RECIPIENTS USING INTRAVASCULAR ULTRASOUND. Pediatric Transplantation, 15, 55-55. (08/2011)
• Kuhn M A, Chinnock R E, Deming D D, Razzouk A J, & Bailey L L. (2009). The Presence of Cardiac Allograft Vasculopathy in Infant and Pediatric Heart Transplant Recipients: A 10-Year Intravascular Ultrasound Study. Journal of Heart and Lung Transplantation, 28(2), S124-S124. (02/2009)
• Kuhn M A, Chinnock R E, Deming D D, Larsen R L, Razzouk A J, & Balley L L. (2009). The Use of Intravascular Ultrasound in the Diagnosis of Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients: A Ten Year Experience. Journal of Heart and Lung Transplantation, 28(2), S297-S297. (02/2009)
• (PEER REVIEWED) Improving Intubation Success Using videolaryngoscope Realtime Analysis (04/2008)

Scholarly Journals--Submitted

• Deming D, Ninnis J, Job L, Wan KOutcomes for Preterm Infants with Ductal Dependent Heart Defects:  Is Long Term Prostaglandin Therapy the Answer  Journal of Pediatrics (06/2008)

Books and Chapters

• Deming D, Wilkins R. Neonatal and Pediatric Respiratory Disorder. : , .